[2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001] [2000] [1999] [1998] [1997] [1996] [1995] [1994] [1993] [1992] [1989]

2017 [to top]

  • Pérez-Mendoza, D., Bertinetti, D., Lorenz, R., Gallegos, M., Herberg, F.W., Sanjuán, J.: A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan. Scientific Reports. 7, 8997-- (2017).
  • Lorenz, R., Moon, E., Kim, J.J., Schmidt, S.H., Sankaran, B., Pavlidis, I.V., Kim, C., Herberg, F.W.: Mutations of PKA cyclic nucleotide binding domains reveal novel aspects of cyclic nucleotide selectivity. Biochemical Journal. 474, 2389-2403 (2017).
  • Campbell, J.C., Henning, P., Franz, E., Sankaran, B., Herberg, F.W., Kim, C.: Structural Basis of Analog Specificity in PKG I and II. ACS Chemical Biology. 12, 2388-2398 (2017).
  • Campbell, J.C., VanSchouwen, B., Lorenz, R., Sankaran, B., Herberg, F.W., Melacini, G., Kim, C.: Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Letters. 591, 221-230 (2017).
  • He, D., Lorenz, R., Kim, C., Herberg, F.W., Lim, C.J.: Switching cyclic nucleotide-selective activation of PKA holoenzyme reveals distinct roles of tandem CNB domains. ACS Chemical Biology. accepted, (2017).
  • Knape, M.J., Herberg, F.W.: Metal coordination in kinases and pseudokinases. Biochemical Society Transactions. 45, 653-663 (2017).
  • Peter, J., Kasper, C., Kaufholz, M., Buschow, R., Isensee, J., Hucho, T., Herberg, F.W., Schwede, F., Stein, C., Jordt, S.-E., Brackmann, M., Spahn, V.: Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. European Journal of Pain. 21, 1072-1086 (2017).
  • Kailing, L.L., Bertinetti, D., Herberg, F.W., Pavlidis, I.V.: A coupled photometric assay for characterization of S-adenosyl-L-homocysteine hydrolases in the physiological hydrolytic direction. New Biotechnology. 39, 11-17 (2017).
  • Knape, M.J., Ballez, M., Burghardt, N.C., Zimmermann, B., Bertinetti, D., Kornev, A.P., Herberg, F.W.: Divalent metal ions control activity and inhibition of protein kinases. Metallomics. in press, (2017).
  • Franz, E., Knape, M.J., Herberg, F.W.: cGMP binding domain D mediates a unique activation mechanism in Plasmodium falciparum PKG. ACS Infect. Dis. accepted, (2017).

2016 [to top]

  • Götz, F., Roske, Y., Schulz, M.S., Autenrieth, K., Bertinetti, D., Faelber, K., Zühlke, K., Kreuchwig, A., Kennedy, E., Krause, G., Daumke, O., Herberg, F.W., Heinemann, U., Klussmann, E.: AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochemical Journal. 473, 1881-1894 (2016).
  • Kibat, J., Schirrmann, T., Knape, M.J., Helmsing, S., Meier, D., Hust, M., Schröder, C., Bertinetti, D., Winter, G., Pardes, K., Funk, M., Vala, A., Giese, N., Herberg, F.W., Dübel, S., Hoheisel, J.D.: Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. New Biotechnology. 33, 574-581 (2016).
  • Kim, J. J., Lorenz, R., Arold, S. T., Reger, A. S., Sankaran, B., Casteel, D. E., Herberg, F. W., Kim, C.: Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 24, 710-720 (2016).
  • Tao, Y., Dong, R., Pavlidis, I.V., Chen, B., Tan, T.: Using imidazolium-based ionic liquids as dual solvent-catalysts for sustainable synthesis of vitamin esters: inspiration from bio- and organo-catalysis. Green Chem. 18, 1240-1248 (2016).
  • Autenrieth, K., Bendzunas, G., Bertinetti, D., Herberg, F.W., Kennedy, E.J.: Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI). ChemBioChem. 17, 693-697 (2016).
  • Kilisch, M., Lytovchenko, O., Arakel, E.C., Bertinetti, D., Schwappach, B.: A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1. Journal of Cell Science. 129, 831-842 (2016).
  • Weiß, M.S., Pavlidis, I.V., Spurr, P., Hanlon, S.P., Wirz, B., Iding, H., Bornscheuer, U.T.: Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine. Org. Biomol. Chem. 14, 10249-10254 (2016).
  • Pavlidis, I.V., Weiß, M.S., Genz, M., Spurr, P., Hanlon, S.P., Wirz, B., Iding, H., Bornscheuer, U.T.: Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines. Nat Chem. 8, 1076-1082 (2016).
  • Tang, Q., Popowicz, G.M., Wang, X., Liu, J., Pavlidis, I.V., Wang, Y.: Lipase-Driven Epoxidation Is A Two-Stage Synergistic Process. ChemistrySelect. 1, 836-839 (2016).
  • Knight, A.M., Nobili, A., van den Bergh, T., Genz, M., Joosten, H., Albrecht, D., Riedel, K., Pavlidis, I.V., Bornscheuer, U.T.: Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases. Applied Microbiology and Biotechnology. 1-9 (2016).
  • Jamsari, J., Ferita, I., Noverta, A., Husada, E.D., Herberg, F.W., Nellen, W., Syukriani, L.: A Pathogenic Isolate of Monopartite PepYLCV DNA A-like Genome Differs Significantly in C1 Gene and CR Sequence, but not in their other Genes. Plant Pathology Journal. 15, 124-134 (2016).
  • Last, D., Müller, J., Dawood, A.W.H., Moldenhauer, E.J., Pavlidis, I.V., Bornscheuer, U.T.: Highly efficient and easy protease-mediated protein purification. Applied Microbiology and Biotechnology. 100, 1945-1953 (2016).

2015 [to top]

  • Hermann, J.S., Skroblin, P., Bertinetti, D., E., H.; L., von der Heide, E.K., Wagener, E., Zenn, H.M., Klussmann, E., Kennedy, E.J., Herberg, F.W.: Neurochondrin is an atypical RIIa-specific A-kinase anchoring protein. BBA Proteins and Proteomics. 1854, 1667 - 75 (2015).
  • Wang, Y., Ho, T.G., Franz, E., Hermann, J.S., Smith, F.D., Henhly, H., Esseltine, J.L., Hanold, L.E., Murph, M.M., Bertinetti, D., Scott, J.D., Herberg, F.W., Kennedy, E.J.: PKA-type I Selective Constrained Peptide Disruptors of AKAP Complexes. ACS Chemical Biology. 10, 1502–1510 (2015).
  • Franz, E., Kim, J., Schneider, O., Bertinetti, D., Kim, C., Herberg, F.W.: The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase. BMC Pharmacology and Toxicology. 16, A51 (2015).
  • babu Manoharan, G., Enkvist, E., Kasari, M., Viht, K., Zenn, M., Prinz, A., Filhol, O., Herberg, F.W., Uri, A.: FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases. Analytical Biochemistry. 481, 10-17 (2015).
  • Jamsari,, Syukriani, L., Utami, H.P., Herberg, F.W., Nellen, W., Ferita, I.: Injection Technique Could Be A New Promising Method for Artificial Infection of Geminivirus Particles in Chili Pepper (Capsicum Annuum L.). Asian Journal of Agricultural Research. 9, 32-32 (2015).
  • Kim, J.J., Flueck, C., Franz, E., Sanabria-Figueroa, E., Thompson, E., Lorenz, R., Bertinetti, D., Baker, D.A., Herberg, F.W., Kim, C.: Crystal Structures of the carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress. PLOS Pathogens. 11, e1004639 (2015).
  • Schwede, F., Bertinetti, D., Langerijs, C.N., Hadders, M.A., Wienk, H., Ellenbroek, J.H., de Koning, E.J.P., Bos, J.L., Herberg, F.W., Genieser, H., Janssen, R.A.J., Rehmann, H.: Structure-Guided Design of Selective Epac1 and Epac2 Agonists. PLOS Biology. 13, e1002038 (2015).
  • Knape, M., Ahuja, L., Bertinetti, D., Burghardt, N., Zimmermann, B., Taylor, S.S., Herberg, F.W.: Divalent metal ions Mg2+ and Ca2+ have distinct effects on protein kinase A activity and regulation. ACS Chemical Biology. 10, 2303-2315 (2015).
  • Mohanty, S., Kennedy, E.J., Herberg, F.W., Hui, R., Taylor, S.S., Langsley, G., Kannan, N.: Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. BBA Proteins and Proteomics. S1570-9639(15)00093-X, (2015).
  • Zhang, P., Knape, M.J., Ahuja, L.G., Keshwani, M.M., King, C.C., Sastri, M., Herberg, F.W., Taylor, S.S.: Single Turnover Autophosphorylation of the PKA RIIβ Holoenzyme. PLoS Biology. 13, e1002192 (2015).
  • Düvel, J., Bense, S., Möller, S., Bertinetti, D., Schwede, F., Morr, M., Eckweiler, D., Genieser, H., Jänsch, L., Herberg, F.W., Frank, R., Häussler, S.: Application of synthetic peptide arrays to uncover c-di-GMP binding motifs. Journal of Bacteriology. 198, 138-146 (2015).
  • Schwede, F., Chepurny, O.G., Kaufholz, M., Bertinetti, D., Leech, C.A., Cabrera, O., Zhu, Y., Mei, F., Cheng, X., Manning Fox, J.E., MacDonald, P.A., Genieser, H., Herberg, F.W., Holz, G.G.: Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion. Molecular Endocrinology. 29, 988-1005 (2015).
  • Lorenz, R., He, D., Kim, C., Lim, C., Herberg, F.W.: Rational design of a PKA-based sensor for cGMP. BMC Pharmacology and Toxicology. 16, A64 (2015).
  • Van Schouwen, B., Selvaratnam, R., Giri, R., Lorenz, R., Herberg, F.W., Kim, C., Melacini, G.: Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). JBC. 290, 28631-28641 (2015).

2014 [to top]

  • Jamsari,, Ferita, I., Syukriani, L., Lalan, H., Herberg, F., Nellen, W.: Existence of Two Distinct Whiteflies in Chilli-Pepper Cultivation in West Sumatra-Indonesia Based on Mitochondria Cytochrome Oxidase I Gene Sequences. Asian Journal of Plant Pathology. 8, 34-44 (2014).
  • Muda, K., Bertinetti, D., Gesellchen, F., Hermann, J.S., von Zweydorf, F., Geerlof, A., Jacob, A., Ueffing, M., Gloeckner, C.J., Herberg, F.W.: The Parkinson related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. PNAS. 111, E34-43 (2014).
  • Huang, G., Kim, J.J., Reger, A., Lorenz, R., Moon, E., Zhao, C., Casteel, D.E., Bertinetti, D., VanSchouwen, B., Selvaratnam, R., Pflugrath, J.W., Sankaran, B., Melacini, G., Herberg, F.W., Kim, C.: Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I. Structure. 22, 116-24 (2014).
  • Möller, S., Alfieri, A., Bertinetti, D., Aquila, M., Schwede, F., Lolicato, M., Rehmann, H., Moroni, A., Herberg, F.W.: Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. ACS Chemical Biology. 9, 1128-37 (2014).
  • Chaikuad, A., Keates, T., Vincke, C., Kaufholz, M., Zenn, M., Zimmermann, B., Gutiérrez, C., Zhang, R., Hatzos-Skintges, C., Joachimiak, A., Muyldermans, S., Herberg, F.W., Knapp, S., Müller, S.: Structure of Cyclin G associated kinase (GAK) Trapped in different Conformations using Nanobodies. Biochemical Journal. 459, 59-69 (2014).
  • Wang, Y., Ho, T.G., Bertinetti, D., Neddermann, M., Franz, E., Mo, G.C.H., Schendowich, L.P., Sukhu, A., Spelts, R.C., Zhang, J., Herberg, F.W., Kennedy, E.J.: Isoform-Selective Disruption of AKAP-localized PKA Using Hydrocarbon Stapled Peptides. ACS Chemical Biology. 9, 635-42 (2014).
  • Isensee, J., Diskar, M., Waldherr, S., Buschow, R., Hasenauer, J., Prinz, A., Allgoewer, F., Herberg, F.W., Hucho, T.: Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci. 127, 216-29 (2014).

2013 [to top]

  • Du, X., Barisch, C., Paschke, P., Herrfurth, C., Bertinetti, O., Pawolleck, N., Otto, H., Rühling, H., Feussner, I., Herberg, F.W., Maniak, M.: Dictyostelium lipid droplets host novel proteins. Eukaryotic Cell. 12, 1517-1529 (2013).
  • Chepurny, O.G., Bertinetti, D., Diskar, M., Leech, C.A., Afshari, P., Tsalkova, T., Cheng, X., Schwede, F., Genieser, H.G., Herberg, F.W., Holz, G.G.: Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Mol Endocrinol. 27(8), 1267-82 (2013).

2012 [to top]

  • Duvel, J., Bertinetti, D., Muller, S., Schwede, F., Morr, M., Wissing, J., Radamm, L., Zimmermann, B., Genieser, H.-G., Jansch, L., Herberg, F.W., Haussler, S.: A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. Journal of Microbiological Methods. 88, 229-36 (2012).
  • Parizek, P., Kummer, L., Rube, P., Prinz, A., Herberg, F.W., Plückthun, A.: Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases. ACS Chem Biol. 7(8), 1356-66 (2012).
  • Kämpf, K., Kübler, S., Herberg, F.W., Ehresmann, A.: Magneto-optic surface plasmon resonance optimum layers: Simulations for biological relevant refractive index changes. Journal of Applied Physics. 112, 034505 (2012).
  • Soberg, K., Larsen, A.C., Diskar, M., Backe, P.H., Bjoras, M., Jahnsen, T., Laerdahl, J.K., Rognes, T., Herberg, F.W., Skalhegg, B.S.: Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA). PLoS One. 7(4), e34838 (2012).
  • Kummer, L., Parizek, P., Rube, P., Millgramm, B., Prinz, A., Mittl, P.R., Kaufholz, M., Zimmermann, B., Herberg, F.W., Plückthun, A.: Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries. Proc Natl Acad Sci U S A. 109(34), E2248-57 (2012).

2011 [to top]

  • Vetter, M.M., Zenn, H.M., Méndez, E., van den Boom, H., Herberg, F.W., Skalhegg, B.S.: The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA. BMC Biochem. 12, 40-40 (2011).
  • Murdoch, H., Vadrevu, S., Prinz, A., Dunlop, A.J., Klussmann, E., Bolger, G.B., Norman, J.C., Houslay, M.D.: Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function. J Cell Sci. 124, 2253-2266 (2011).
  • Schmidt, J., Müsken, M., Becker, T., Magnowska, Z., Bertinetti, D., Möller, S., Zimmermann, B., Herberg, F.W., Jänsch, L., Häussler, S.: The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling. PLoS One. 6(3), e18184 (2011).
  • Christian, F., Szaszák, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Götz, F., Zühlke, K., Moutty, M., Göttert, H., Joshi, M., Reif, B., Haase, H., Morano, I., Grossmann, S., Klukovits, A., Verli, J., Gáspár, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H.G., Herberg, F.W., Willoughby, D., Cooper, D.M., Baillie, G.S., Houslay, M.D., Kries, J.P. von, Zimmermann, B., Rosenthal, W., Klussmann, E.: Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem. 286, 9079-9096 (2011).
  • Stoevesandt, O., Vetter, M., Kastelic, D., Palmer, E.A., He, M., Taussig, M.J.: Cell free expression put on the spot: advances in repeatable protein arraying from DNA (DAPA). N Biotechnol. 28, 282-290 (2011).
  • Hanke, S.E., Bertinetti, D., Badel, A., Schweinsberg, S., Genieser, H.G., Herberg, F.W.: Cyclic nucleotides as affinity tools: phosphorothioate cAMP analogues address specific PKA subproteomes. N Biotechnol. 28, 294-301 (2011).
  • Lolicato, M., Nardini, M., Gazzarrini, S., Moeller, S., Bertinetti, D., Herberg, F.W., Bolognesi, M., Martin, H., Fasolini, M., Bertrand, J.A., Arrigoni, C., Thiel, G., Moroni, A.: Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels. J Biol Chem. 286, 44811-20 (2011).

2010 [to top]

  • Diskar, M., Zenn, H.M., Kaupisch, A., Kaufholz, M., Brockmeyer, S., Sohmen, D., Berrera, M., Zaccolo, M., Boshart, M., Herberg, F.W., Prinz, A.: Regulation of cAMP-dependent protein kinases: the human Protein Kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop. J Biol Chem. 285, 35910-8 (2010).
  • Erlbruch, A., Hung, C.W., Seidler, J., Borrmann, K., Gesellchen, F., König, N., Kübler, D., Herberg, F.W., Lehmann, W.D., Bossemeyer, D.: Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics. 10, 2890-2900 (2010).
  • Seitz, C., Du, X., Pawolleck, N., von Loehneysen, K., Bertinetti, O., Herberg, F.W., Maniak, M.: Functional analysis of the lipid droplet proteome of Dictyostelium discoideum. EUROPEAN JOURNAL OF CELL BIOLOGY. pp. 34-35. ELSEVIER GMBH, URBAN & FISCHER VERLAG, OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY (2010).
  • Gloriam, D.E., Orchard, S., Bertinetti, D., Björling, E., Bongcam-Rudloff, E., Borrebaeck, C.A., Bourbeillon, J., Bradbury, A.R., de Daruvar, A., Dübel, S., Frank, R., Gibson, T.J., Gold, L., Haslam, N., Herberg, F.W., Hiltke, T., Hoheisel, J.D., Kerrien, S., Koegl, M., Konthur, Z., Korn, B., Landegren, U., Montecchi-Palazzi, L., Palcy, S., Rodriguez, H., Schweinsberg, S., Sievert, V., Stoevesandt, O., Taussig, M.J., Ueffing, M., Uhlén, M., van der Maarel, S., Wingren, C., Woollard, P., Sherman, D.J., Hermjakob, H.: A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics. 9, 1-10 (2010).
  • Hundsrucker, C., Skroblin, P., Christian, F., Zenn, H.M., Popara, V., Joshi, M., Eichhorst, J., Wiesner, B., Herberg, F.W., Reif, B., Rosenthal, W., Klussmann, E.: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem. 285, 5507-5521 (2010).

2009 [to top]

  • Bertinetti, D., Schweinsberg, S., Hanke, S.E., Schwede, F., Bertinetti, O., Drewianka, S., Genieser, H.G., Herberg, F.W.: Chemical tools selectively target components of the PKA system. BMC Chem Biol. 9, 3-3 (2009).
  • Viertlboeck, B.C., Schweinsberg, S., Schmitt, R., Herberg, F.W., Gobel, T.W.: The chicken leukocyte receptor complex encodes a family of different affinity FcY receptors. J Immunol. 182, 6985-92 (2009).
  • Follmann, H., Brownson, C.: Darwin’s warm little pond revisited: from molecules to the origin of life. Naturwissenschaften. 96, 1265-1292 (2009).
  • Wojtal, K.A., Diskar, M., Herberg, F.W., Hoekstra, D., van Ijzendoorn, S.C.: Regulatory subunit I-controlled protein kinase A activity is required for apical bile canalicular lumen development in hepatocytes. J Biol Chem. 284, 20773-80 (2009).
  • Schlüter, S., Franz, C., Gesellchen, F., Bertinetti, O., Herberg, F.W., Schmidt, F.: The high biofilm-encoding Bee locus: a second pilus gene cluster in Enterococcus faecalis? Current Microbiology. 59, 206-211 (2009).
  • Prinz, A., Herberg, F.W.: PrKX. USCD Nature Molecule Pages. (2009).

2008 [to top]

  • Hamacher, M., Herberg, F., Ueffing, M., Meyer, H.E.: Seven successful years of Omics research: The Human Brain Proteome Project within the National German Research Network (NGFN). Proteomics. 8, 1116-1117 (2008).
  • Zimmermann, B., Schweinsberg, S., Drewianka, S., Herberg, F.W.: Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J. 413, 93-101 (2008).
  • Collins, D.M., Murdoch, H., Dunlop, A.J., Charych, E., Baillie, G.S., Wang, Q., Herberg, F.W., Brandon, N., Prinz, A., Houslay, M.D.: Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal. 20, 2356-2369 (2008).
  • Moll, D., Prinz, A., Brendel, C.M., Berrera, M., Guske, K., Zaccolo, M., Genieser, H.G., Herberg, F.W.: Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog. BMC Biochem. 9, 18 (2008).
  • Farquhar, M.J., Harris, H.J., Diskar, M., Jones, S., Mee, C.J., Nielsen, S.U., Brimacombe, C.L., Molina, S., Toms, G.L., Maurel, P., Howl, J., Herberg, F.W., van Ijzendoorn, S.C., Balfe, P., McKeating, J.A.: Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. J Virol. 82, 8797-8811 (2008).
  • Schweinsberg, S., Moll, D., Burghardt, N.C., Hahnefeld, C., Schwede, F., Zimmermann, B., Drewianka, S., Werner, L., Kleinjung, F., Genieser, H.G., Schuchhardt, J., Herberg, F.W.: Systematic interpretation of cyclic nucleotide binding studies using KinetXBase. Proteomics. 8, 1212-1220 (2008).
  • Prinz, A., Reither, G., Diskar, M., Schultz, C.: Fluorescence and bioluminescence procedures for functional proteomics. Proteomics. 8, 1179-1196 (2008).

2007 [to top]

  • Moll, D., Schweinsberg, S., Hammann, C., Herberg, F.W.: Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A. Biol Chem. 388, 163-72 (2007).
  • Diskar, M., Zenn, H.M., Kaupisch, A., Prinz, A., Herberg, F.W.: Molecular basis for isoform-specific autoregulation of protein kinase A. Cell Signal. 19, 2024-34 (2007).
  • Mirow, N., Zimmermann, B., Maleszka, A., Knobl, H., Tenderich, G., Koerfer, R., Herberg, F.W.: Plasma protein binding properties to immobilized heparin and heparin-albumin conjugate. Artif Organs. 31, 466-71 (2007).
  • Taussig, M.J., Stoevesandt, O., Borrebaeck, C.A.K., Bradbury, A.R., Cahill, D., Cambillau, C., d. Daruvar, A., Dubel, S., Eichler, J., Frank, R., Gibson, T.J., Gloriam, D., Gold, L., Herberg, F.W., Hermjakob, H., Hoheisel, J.D., Joos, T.O., Kallioniemi, O., Koegl, M., Konthur, Z., Korn, B., Kremmer, E., Krobitsch, S., Landegren, U., v.d. Maarel, S., McCafferty, J., Muyldermans, S., Nygren, P., Palcy, S., Pluckthun, A., Polic, B., Przybylski, M., Saviranta, P., Sawyer, A., Sherman, D.J., Skerra, A., Templin, M., Ueffing, M., Uhlen, M.: ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Meth. 4, 13-17 (2007).
  • Hamacher, M., Stephan, C., Eisenacher, M., van Hall, A., Marcus, K., Martens, L., Park, Y.M., Gutstein, H.B., Herberg, F.W., Meyer, H.E.: Proteomics for everyday use: activities of the HUPO Brain Proteome Project during the 5th HUPO World Congress. Proteomics. 7, 1012-1015 (2007).
  • Ruppelt, A., Mosenden, R., Gronholm, M., Aandahl, E.M., Tobin, D., Carlson, C.R., Abrahamsen, H., Herberg, F.W., Carpen, O., Tasken, K.: Inhibition of T Cell Activation by Cyclic Adenosine 5'-Monophosphate Requires Lipid Raft Targeting of Protein Kinase A Type I by the A-Kinase Anchoring Protein Ezrin. J Immunol. 179, 5159-5168 (2007).
  • Viertlboeck, B.C., Schweinsberg, S., Hanczaruk, M.A., Schmitt, R., Pasquier, L.D., Herberg, F.W., Göbel, T.W.: The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor. Proc Natl Acad Sci U S A. 104, 11718-11723 (2007).
  • Viht, K., Schweinsberg, S., Lust, M., Vaasa, A., Raidaru, G., Lavogina, D., Uri, A., Herberg, F.W.: Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase. Anal Biochem. 362, 268-277 (2007).

2006 [to top]

  • Gesellchen, F., Bertinetti, O., Herberg, F.W.: Analysis of posttranslational modifications exemplified using protein kinase A. Biochim Biophys Acta. 1764, 1788-800 (2006).
  • Hamacher, M., Apweiler, R., Arnold, G., Becker, A., Blüggel, M., Carrette, O., Colvis, C., Dunn, M.J., Fröhlich, T., Fountoulakis, M., van Hall, A., Herberg, F.W., Ji, J., Ji, J., Kretzschmar, H., Lewczuk, P., Lubec, G., Marcus, K., Martens, L., Bustamante, N.P., Park, Y.M., Pennington, S.R., Robben, J., Stühler, K., Reidegeld, K.A., Riederer, P., Rossier, J., Sanchez, J.C., Schrader, M., Stephan, C., Tagle, D., Thiele, H., Wang, J., Wiltfang, J., Yoo, J.S., Zhang, C., Klose, J., Meyer, H.E.: HUPO Brain Proteome Project: summary of the pilot phase and introduction of a comprehensive data reprocessing strategy. Proteomics. 6, 4890-4898 (2006).
  • Prinz, A., Diskar, M., Herberg, F.W.: Application of bioluminescence resonance energy transfer (BRET) for biomolecular interaction studies. Chembiochem. 7, 1007-12 (2006).
  • Stokka, A.J., Gesellchen, F., Carlson, C.R., Scott, J.D., Herberg, F.W., Tasken, K.: Characterization of A-kinase-anchoring disruptors using a solution-based assay. Biochem J. 400, 493-9 (2006).
  • Gesellchen, F., Prinz, A., Zimmermann, B., Herberg, F.W.: Quantification of cAMP antagonist action in vitro and in living cells. Eur J Cell Biol. 85, 663-72 (2006).
  • Terrin, A., Benedetto, G., Pertegato, V., Cheung, Y., Baillie, G., Lynch, M.J., Elvassore, N., Prinz, A., Herberg, F.W., Houslay, M.D., Zaccolo, M.: PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different cAMP: role of compartmentalized phosphodiesterases. JCB. 175, 441-451 (2006).
  • Moll, D., Prinz, A., Gesellchen, F., Drewianka, S., Zimmermann, B., Herberg, F.W.: Biomolecular interaction analysis in functional proteomics. J Neural Transm. 113, 1015-32 (2006).
  • Prinz, A., Diskar, M., Erlbruch, A., Herberg, F.W.: Novel, isotype-specific sensors for protein kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET). Cell Signal. 18, 1616-25 (2006).
  • Seitz, H., Hutschenreiter, S., Hultschig, C., Zeilinger, C., Zimmermann, B., Kleinjung, F., Schuchhardt, J., Eickhoff, H., Herberg, F.W.: Differential binding studies applying functional protein microarrays and surface plasmon resonance. Proteomics. 6, 5132-5139 (2006).
  • Hundsrucker, C., Krause, G., Beyermann, M., Prinz, A., Zimmermann, B., Diekmann, O., Lorenz, D., Stefan, E., Nedvetsky, P., Dathe, M., Christian, F., McSorley, T., Krause, E., McConnachie, G., Herberg, F.W., Scott, J.D., Rosenthal, W., Klussmann, E.: High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J. 396, 297-306 (2006).

2005 [to top]

  • Gesellchen, F., Zimmermann, B., Herberg, F.W.: Direct optical detection of protein-ligand interactions. Methods Mol Biol. 305, 17-46 (2005).
  • Ramanavieius, A., Herberg, F.W., Hutschenreiter, S., Zimmermann, B., Lapenaite, I., Kausaite, A., Finkelsteinas, A., Ramanavieiene, A.: Biochemical application of surface Plasmon resonance biosensors. Acta Medica Lituanica. 12, 1-9 (2005).
  • Diskar, M., Herberg, F.W., Prinz, A.: Investigating human protein kinase X holoenzyme formation using bioluminescence resonance energy transfer (BRET). FEBS JOURNAL. p. 303 (2005).
  • Hahnefeld, C., Moll, D., Goette, M., Herberg, F.W.: Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA. Biol Chem. 386, 623-31 (2005).

2004 [to top]

  • Hahnefeld, C., Drewianka, S., Herberg, F.W.: Determination of kinetic data using surface plasmon resonance biosensors. Methods Mol Med. 94, 299-320 (2004).
  • Thierse, H.J., Moulon, C., Allespach, Y., Zimmermann, B., Doetze, A., Kuppig, S., Wild, D., Herberg, F.W., Weltzien, H.U.: Metal-protein complex-mediated transport and delivery of Ni2+ to TCR/MHC contact sites in nickel-specific human T cell activation. J Immunol. 172, 1926-1934 (2004).
  • Follmann, H.: Deoxyribonucleotides: the unusual chemistry and biochemistry of DNA precursors. Chem. Soc. Rev. 33, 225-233 (2004).
  • Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F.W., Valenti, G., Bachmann, S., Rosenthal, W., Klussmann, E.: Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem. 279, 26654-26665 (2004).
  • Heide, H., Kalisz, H.M., Follmann, H.: The oxygen evolving enhancer protein 1 (OEE) of photosystem II in green algae exhibits thioredoxin activity. Journal of Plant Physiology. 161, 139 - 149 (2004).

2003 [to top]

  • Yaqub, S., Abrahamsen, H., Zimmerman, B., Kholod, N., Torgersen, K.M., Mustelin, T., Herberg, F.W., Taskén, K., Vang, T.: Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain. Biochem J. 372, 271-278 (2003).
  • Gronholm, M., Vossebein, L., Kuja-Panula, J., Teesalu, T., Carlson, C.R., Vaheri, A., Rauvala, H., Herberg, F.W., Tasken, K., Carpen, O.: Merlin links to the cAMP neuronal signaling pathway by anchoring the Rib subunit of protein kinase A. JOURNAL OF NEUROCHEMISTRY. p. 122 (2003).
  • Grönholm, M., Vossebein, L., Carlson, C.R., Kuja-Panula, J., Teesalu, T., Alfthan, K., Vaheri, A., Rauvala, H., Herberg, F.W., Taskén, K., Carpén, O.: Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem. 278, 41167-41172 (2003).
  • Sichelschmidt, O.J., Hahnefeld, C., Hohlfeld, T., Herberg, F.W., Schror, K.: Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity. Cardiovasc Res. 58, 602-10 (2003).

2002 [to top]

  • Sichelschmidt, O.J., Hahnefeld, C., Hohlfeld, T., Herberg, F.W., Schror, K.: A triazolopyrimidine reduces myocardial ischemic reperfusion injury by stimulating PKAII-dependent phosphorylation of phospholamban. CIRCULATION (2002).

2001 [to top]

  • Landsverk, H.B., Carlson, C.R., Steen, R.L., Vossebein, L., Herberg, F.W., Tasken, K., Collas, P.: Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis. J Cell Sci. 114, 3255-64 (2001).
  • Carlson, C.R., Witczak, O., Vossebein, L., Labbe, J.C., Skalhegg, B.S., Keryer, G., Herberg, F.W., Collas, P., Tasken, K.: CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis. J Cell Sci. 114, 3243-54 (2001).
  • Suer, S., Sickmann, A., Meyer, H.E., Herberg, F.W., Heilmeyer, J.: Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. Eur J Biochem. 268, 2099-106 (2001).

2000 [to top]

  • Tóth, A., Kiss, E., Herberg, F.W., Gergely, P., Hartshorne, D.J., Erdödi, F.: Study of the subunit interactions in myosin phosphatase by surface plasmon resonance. Eur J Biochem. 267, 1687-1697 (2000).
  • Herzog, A., Szegedi, C., Jona, I., Herberg, F.W., Varsanyi, M.: Surface plasmon resonance studies prove the interaction of skeletal muscle sarcoplasmic reticular Ca(2+) release channel/ryanodine receptor with calsequestrin. FEBS Lett. 472, 73-7 (2000).
  • Herberg, F.W., Maleszka, A., Eide, T., Vossebein, L., Tasken, K.: Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. J Mol Biol. 298, 329-39 (2000).
  • Wang, X., Herberg, F.W., Laue, M.M., Wullner, C., Hu, B., Petrasch-Parwez, E., Kilimann, M.W.: Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. J Neurosci. 20, 8551-65 (2000).
  • Zimmermann, B., Hahnefeld, C., Herberg, F.W.: Divalent metals modulate the binding affinity of physiological inhibitors of protein kinase A. BIOPHYSICAL JOURNAL (2000).
  • Jaquet, K., Deppermann, S., Herberg, F.W.: Phospho-NMR-spectrocopy reveals chances in the chemical environment P-Thr197 in the catalytic subunit of cAMP-dependent protein-kinase. BIOPHYSICAL JOURNAL (2000).

1999 [to top]

  • Zimmermann, B., Chiorini, J.A., Ma, Y., Kotin, R.M., Herberg, F.W.: PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. J Biol Chem. 274, 5370-8 (1999).
  • Gehrmann, T., Gulkan, H., Suer, S., Herberg, F.W., Balla, A., Vereb, G., Mayr, G.W., Heilmeyer, J.: Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230. Biochim Biophys Acta. 1437, 341-56 (1999).
  • Schliebs, W., Saidowsky, J., Agianian, B., Dodt, G., Herberg, F.W., Kunau, W.H.: Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14. J Biol Chem. 274, 5666-73 (1999).
  • Herberg, F.W., Doyle, M.L., Cox, S., Taylor, S.S.: Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry. 38, 6352-60 (1999).

1998 [to top]

  • Reiffert, S.U., Jaquet, K., Heilmeyer, J., Herberg, F.W.: Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I. Biochemistry. 37, 13516-25 (1998).
  • Chiorini, J.A., Zimmermann, B., Yang, L., Smith, R.H., Ahearn, A., Herberg, F.W., Kotin, R.M.: Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Mol Cell Biol. 18, 5921-5929 (1998).

1997 [to top]

  • Leon, D.A., Herberg, F.W., Banky, P., Taylor, S.S.: A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif. J Biol Chem. 272, 28431-7 (1997).
  • Herberg, F.W., Zimmermann, B., McGlone, M., Taylor, S.S.: Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci. 6, 569-79 (1997).

1996 [to top]

  • Herberg, F.W., Taylor, S.S., Dostmann, W.R.: Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry. 35, 2934-42 (1996).

1995 [to top]

  • Wild, N., Herberg, F.W., Hofmann, F., Dostmann, W.R.: Expression of a chimeric, cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I alpha. FEBS Lett. 374, 356-62 (1995).
  • Su, Y., Dostmann, W.R., Herberg, F.W., Durick, K., Xuong, N.H., Eyck, L.T., Taylor, S.S., Varughese, K.I.: Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science. 269, 807-813 (1995).

1994 [to top]

  • Herberg, F.W., Dostmann, W.R., Zorn, M., Davis, S.J., Taylor, S.S.: Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry. 33, 7485-94 (1994).

1993 [to top]

  • Buechler, Y.J., Herberg, F.W., Taylor, S.S.: Regulation-defective mutants of type I cAMP-dependent protein kinase. Consequences of replacing arginine 94 and arginine 95. J Biol Chem. 268, 16495-503 (1993).
  • Herberg, F.W., Taylor, S.S.: Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry. 32, 14015-22 (1993).
  • Taylor, S.S., Zheng, J., Radzio-Andzelm, E., Knighton, D.R., Eyck, L.F.T., Sowadski, J.M., Herberg, F.W., Yonemoto, W.M.: cAMP-dependent protein kinase defines a family of enzymes. Philos Trans R Soc Lond B Biol Sci. 340, 315-324 (1993).
  • Taylor, S.S., Radzio-Andzelm, E., Knighton, D.R., Eyck, L.F.T., Sowadski, J.M., Herberg, F.W., Yonemoto, W., Zheng, J.: Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family. Receptor. 3, 165-72 (1993).
  • Herberg, F.W., Bell, S.M., Taylor, S.S.: Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states. Protein Eng. 6, 771-7 (1993).

1992 [to top]

  • Benterbusch, R., Herberg, F.W., Melzer, W., Thieleczek, R.: Excitation-contraction coupling in a pre-vertebrate twitch muscle: the myotomes of Branchiostoma lanceolatum. J Membr Biol. 129, 237-52 (1992).

1989 [to top]


Book chapter


  • Lorenz, R., Bertinetti, D., Herberg, F.W.: cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors. Presented at the , Berlin, Heidelberg (2016).


  • Lorenz, R., Hahnefeld, C., Möller, S., Bertinetti, D., Herberg, F.W.: Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways. In: Cheng, X. (ed.) Cyclic Nucleotide Signaling. pp. 203-23. CRC Press (2015).


  • Eichler, C., Herberg, F.W., Schmidt, F., Schaffrath, R.: Does the bee locus encode an additional or alternative pilus in Enterococcus faecalis? In: Mendez-Vilas, A. (ed.) Worldwide Research Efforts in the Fighting against Microbial Pathogens: From Basic Research to Technological Developments. pp. 134-8. BrownWalker Press (2013).


  • Zenn, H.-M., Hutschenreiter, S., Herberg, F.W.: Anti-Histidine Antibodies as Tools for Reversible Capturing of His-Tagged Fusion Proteins for Subsequent Binding Analysis. In: Kontermann, R. and Dübel, S. (eds.) Antibody Engineering. pp. 667-681. Springer Berlin Heidelberg (2010).


  • Moll, D., Zimmermann, B., Gesellchen, F., Herberg, F.W.: Current developments for the in vitro characterization of protein interactions. In: Marcus, K., Stühler, K., v. Hall, A., Hamacher, M., Warscheid, B., and Meyer, H.E. (eds.) Proteomics in drug research. pp. 159-172. Wiley-VCH Verlag (2006).


  • Vossebein, L., Herberg, F.W.: Multiplicity and Anchoring of PKA Isozymes Detected by Surface Plasmon Resonance. In: Heilmeyer, L. and Friedrich, P. (eds.) Protein Modules in Cellular Signalling. pp. 50-58. IOS Press (2001).


  • Herberg, F.W., Zimmermann, B.: Analysis of protein kinase interactions using biomolecular interaction analysis. In: Hardie, D.G. (ed.) Protein Phosphorylation - A Practical Approach. pp. 335-371. Oxford University Press (1999).


  • Reiffert, S., Jaquet, K., Heilmeyer, L.M.G., Herberg, F.W.: Studies on the Function of Different Phosphoforms of Cardiac Troponin I. In: Heilmeyer, L. (ed.) Interacting Protein Domains: Their Role in Signal and Energy Transdution. pp. 281-288. Springer (1997).
  • Maleszka, A., Herberg, F.W.: Interaction Studies using Biosensors. In: Heilmeyer, L. (ed.) Interacting Protein Domains: Their Role in Signal and Energy Transdution. pp. 27-36. Springer (1997).
  • Zimmermann, B., Klink, A., Rappolt, G., Herberg, F.W.: Protein Kinase X: A Novel Human Protein Kinase related to the Catalytic Subunit of cAMP-dependent Protein Kinase. In: Heilmeyer, L. (ed.) Interacting Protein Domains: Their Role in Signal and Energy Transdution. pp. 15-18. Springer (1997).


  • Herberg, F.W., Yonemoto, W., Taylor, S.S.: The Catalytic Subunit of cAMP-dependent Protein Kinase. In: Heilmeyer, L.M.G. (ed.) Tyrosine Phosphorylation/ Dephosphorylation and Downstream Signalling. pp. 203-213. Springer (1993).


  • Herberg, F.W., Taylor, S.S.: Conformational and Shape Changes associated with cAMP-dependent Protein Kinase. In: Heilmeyer, L.M.G. (ed.) Cellular Regulation by Protein Phosphorylation. pp. 119-123. Springer (1991).
  • Taylor, S.S., Yonomoto, W., Dostmann, W., Knighton, D., Sowadski, J., Herberg, F.W., Buechler, J., Ji-Buechler, Y.: Protein kinase Structure and Function: cAMP-dependent Protein Kinase. In: Heilmeyer, L.M.G. (ed.) Cellular Regulation by Protein Phosphorylation. pp. 91-105. Springer (1991).

  • Seitz, H.: Protein Microarrays - Proteins in a Nutshell -, (2011).
  • Prinz, A.: Qualitative und quantitative Analyse von Protein-Protein Wechselwirkungen in der cAMP-vermittelten Signaltransduktionskaskade mittels Biolumineszenz Resonanz Energie Transfer, (2010).

PhD Thesis
  • Kim, J.J.: Structural insights into the allosteric activation mechanism of cGMP-dependent protein kinase I, (2016).
  • Kaufholz, M.: Charakterisierung eines cAMP-abhängigen Signalmoduls zur Regulation von TRPV1, (2016).
  • Lorenz, R.: Molecular basis for binding specifity of cyclic nucleotides, (2016).
  • Knape, M.J.: Die Rolle divalenter Metallionen für die Struktur und Funktion der cAMP-abhängigen Proteinkinase, (2015).
  • Beckmann, S.: Targeting von COP-I-Vesikeln an die ER-exit sites in Hefe, (2015).
  • Hermann, J.S.M.: Neurochondrin und Rack1 vermitteln die Signalintegration der Proteinkinase A, (2014).
  • Muda, K.: Untersuchungen zur Regulation der Parkinsonrelevanten Proteinkinase LRRK2 durch PKA, (2014).
  • Möller, S.: Analyse von Protein-Ligand Interaktionen zur Charakterisierung zyklonukleotidbindender Proteine, (2014).
  • Brockmeyer, S.: Identifizierung und funktionelle Charakterisierung neuer A-Kinase-Ankerproteine (AKAPs) im Modellorganismus C. elegans,, (2012).
  • Badel, A.: Untersuchung zur Rolle von Isoformen katalytischer Untereinheiten der PKA,, (2012).
  • Hanke, S.E.: Untersuchung zum Phosphorylierungsstatus der katalytischen Untereinheit der PKA mittels proteomischer Techniken,, (2011).
  • Zenn, H.M.: Regulation und Koordination der Proteinkinase A im cAMP-vermittelten Signalweg,, (2010).
  • Diskar, M.: Funktionelle Charakterisierung von Proteinkinase A Isoformen in Eukaryoten, (2009).
  • Kaupisch, A.: Biochemische und zellbiologische Charakterisierung der humanen Proteinkinase X,, (2008).
  • Erlbruch, A.: Entwicklung einer expressionsfreien Tandem-Affinitätsreinigung zur Untersuchung von Protein-Protein-Interaktionen der Isoformen der katalytischen Untereinheite der Proteinkinase A, (2007).
  • Werther, M.: Identifizierung und Optimierung von Biomarkern der Karzinogenese des duktalen Pankreaskarzinoms, des Kolonkarzinoms und des Prostatakarzinoms.,, (2007).
  • Moll, D.: Molekulare Mechanismen der cAMP-vermittelten Signaltransduktion,, (2007).
  • Zielinski, D.: Identifikation, Analyse und Validierung von Markerproteinen zur Prädiktion einer Therapieresponse bei der Behandlung des metastasierten Mammakarzinoms mit Trastuzumab (Herceptin) und Pertuzumab (Omnitarg), (2006).
  • Hahnefeld, C.: Regulation von zyklonukleotidabhängigen Proteinkinasen, (2004).
  • v. d. Boom, H.: Biochemische und zellbiologische Charakterisierung humaner Isoformen katalytischer Untereinheiten der cAMP-abhängigen Proteinkinase (PKA), (2003).
  • Vossebein, L.: Regulation von Signaltransduktionselementen über Ankerproteine, (2002).

Diploma/Master Thesis
  • Hasna, B.A.: Vergleichende Studien zur Zyklonukleotidbindung der Domänen A und B der regulatorischen Untereinheiten vom Typ II der humanen PKA, (2017).
  • Henning, P.: Binding and activation studies on human PKG isoforms, (2017).
  • Brachmann, C.: Charakterisierung des zyklonukleotidbindenden Proteins PA3353 mittels c-di-GMP-Analoga, (2016).
  • Rohleder, A.: Untersuchung zur Selektivität von cAMP-Analoga zu PKA und EPAC, (2016).
  • Deder, L.: Untersuchung zum Interaktionsprofil von 14-3-3 Isoformen an LRRK2, (2016).
  • Abid, D.: Biochemische Charakterisierung einer PKA Cß-Mutatio, S53L, assoziiert mit Cushing Syndrom, (2016).
  • Dörfler, S.: Untersuchung zur AKAP Isoformspezifität mittels eines Alanin-Scans an STAD-2, (2016).
  • Relling, I.: Paralleler Nachweis von Drogen mittels immunologischer Methoden, (2015).
  • Schneider, O.: Rolle der aC-Helix in der CNB-D bei der cGMP-abhängigen Proteinkinase des Malariaparasiten Plasmodium falciparum, (2015).
  • Breitenstein, H.: Untersuchungen zur Regulation der Parkinson-assoziierten Proteinkinase LRRK2 durch PKB/Akt, (2014).
  • Schmidt, S.: Analysen zur cGMP-Bindung an regulatorische Domänen der humanen cGMP-abhängigen Proteinkinasen, (2014).
  • Ballez, M.: Regulation der cAMP-abhängigen Proteinkinase durch Metalle, (2014).
  • Asmussen, J.: Untersuchungen zur Rolle von Serin 53 Phosphorylierung in der Glycin-reichen Schleife der PKA, (2014).
  • Neddermann, M.: Untersuchungen an Komponenten des cAMP Signalweges, (2014).
  • Theil, M.: Regulation der Flavonoid-Biosynthese bei Kältestress von Arabidopsis thaliana, (2013).
  • Franz, E.: Bindungs- und Aktivierungsstudien der cGMP-abhängigen Proteinkinase aus diversen Organismen, (2013).
  • Spieker, M.: Charakterisierung der funktionellen Domänen von LRRK2 (Leucine-rich repeat kinase2), (2013).
  • Arens, N.: Molekularbiologische und phytochemische Untersuchungen in Trichomen verschiedener Nicotina tabacum Genbank-Akzessionen mit besonderer Betrachtung von Genen des Sekundärmetabolismus, (2012).
  • Groth, K.: Biochemische Untersuchung zu bisher wenig charakterisierten cAMP-abhängigen Proteinkinasen, (2012).
  • Lorenz, R.: Structure-function studies on CNB domains of catalytic nucleotide-dependent protein kinases, (2012).
  • Schick, A.: Charakterisierung potentieller Interaktoren der katalytischen Untereinheit der PKA, (2011).
  • Millgramm, B.: Vergleichende Untersuchung zur Spezifität in vitro selektierter Bindeproteine, (2011).
  • Vetter, M.M.: Ein chemisch-genetischer Ansatz zur Identifikation von PKA-Substraten, (2011).
  • Thomik, T.: Identification and genetic characterization of maize cell wall variation for improved biorefinery feedstock characteristics, (2011).
  • Knape, M.: Entwicklung eines mikro- u. nanostrukturierten Templates für ein DAPA-System (DNA-Array-to-Protein-Array), (2010).
  • Gagoski, D.: Rekombinante Expression und biochemische Charakterisierung eines thermostabilen Motorproteins, (2010).
  • Rube, P.: Charakterisierung natürlicher und künstlicher Kinasebindeproteine, (2010).
  • von der Heide, E.K.: Charakterisierung potentieller Interaktionspartner der cAMP-abhängigen Proteinkinase, (2010).
  • Beckmann, S.: Identifikation von Interaktionspartnern der PKA-C-Untereinheiten basierend auf einem Split-Ubiquitin-Sytem, (2010).
  • Buschow, R.: Quantitative Analyse Neuronaler Subgruppen mit Hilfe automatisierter Immunfluoreszenz, (2009).
  • Koch, E.M.: Biochemische Analysen des dAMP-Interaktoms aus neuronalem Gewebe, (2009).
  • Muda, K.: Untersuchung zur Regulation von LRRK2 (PARK 8), (2009).
  • Möller, S.: Herstelliung u. kraftmikroskopische Charakterisierung von Zyklonukleotid-Bindedomänen der PKA, (2009).
  • Meier, A.: Qunatifizierung von zyklischen Nukleotiden in vivo und in vitro, (2009).
  • Brockmeyer, S.: Analyse von Protein-Protein Wechselwirkungen in der cAMP-vermittelten Signalkaskade mittels Biomunineszenz Resonanz Energie Transfer (BRET), (2008).
  • Lang, D.: Massenspektrometrische Charakterisierung von Komponenten des cAMP-Signalwegs, (2008).
  • Hesse, S.: Charakterisierung potentieller Interaktoren der pflanzlichen Aurora Kinase AtAutora 1, (2008).
  • Hermann, J.S.M.: Struktur- und Funktionsuntersuchung an LRRK2, (2008).
  • Röhr, C.: Erstellung und Analyse von Genexpressionsprofilen in einem Mausmodell für Schlaganfall, (2008).
  • Kaufholz, M.: Charakterisierung von Strukturmotiven katalytischer Untereinheiten der PKA, (2008).
  • Guske, K.: Neue Strategien zur Interaktionsanalyse der Komponenten des cAMP-Signalwegs, (2008).
  • Mathieu, N.: Is Drosophila Mu2 the orthologue of mammalian MDC1?, (2007).
  • Wille, C.: Plastochinon-9-Stoffwechsel in Arabidopsis-Mutanten mit Störungen in der Chinonlipid-Biosynthese, (2007).
  • Budano, N.: Rekombinante Expression von Inositolphosphatkinasen und deren funktionelle Charakterisierung, (2007).
  • Badel, A.: Untersuchung zur Spezifität von Isoformen der cAMP abhängigen Proteinkinase, (2006).
  • Schneider-Muntau, A.: Funktionelle Untersuchung einer Genvariante im Promoter des mikrosomalen Triglyzerid Transfer Proteins (MTP)-Promotor, (2006).
  • Roth, S.E.: Massenspektrometrische Analyse differenziell exprimierter Proteine, (2006).
  • Zenn, M.: Klonierung, Expression und Charakterisierung von zyklonukleotidbindenden Domänen mit modifizierten kinetischen Eigenschaften, (2005).
  • Burghardt, N.C.G.: Biochemische und strukturbiologische Untersuchungen zur Zyklonukleotidbindung bei der cAMP-abhängigen Proteinkinase, (2005).
  • Ricci, D.: Biochemische Untersuchungen zur Substratspezifität humaner cAMPabhängiger Proteinkinasen, (2005).
  • Diskar, M.: In vivo Charakterisierung von PKA Isoformen in eukaryotischen Zellen, (2005).
  • Braun, M.: In vitro Charakterisierung des S.pombe Kinesins "Tea2p", (2004).
  • Thürmer, A.: Funktion der cAMP-abhängigen Proteinkinase in Mensch und Dictyostelium, (2004).
  • Schweinsberg, S.: Interaktionsstudien an physiologischen und synthetischen Kinaseinhibitoren, (2004).
  • Götte, M.: In silico Untersuchungen zur cAMP-Bindung an regulatorische Untereinheiten der cAMP-abhängigen Proteinkinase, (2004).
  • Erlbruch, A.: Biolumineszenz Resonanz Energie Transfer (BRET): Eine neue Methodik für in vivo Interaktionsstudien an der cAMP abhängigen Proteinkinase (PKA), (2003).
  • Moll, D.: Ist das Triazolpyrimidin Trapidil ein Aktivator der cAMP-abhänigigen Proteinkinase?, (2003).

Bachelor Thesis
  • Kuijpers, A.: Development of an N-Terminal Esterase Immobilization Approach based on Luciferin-Like Click Chemistry, (2017).
  • Nordmeier, J.C.: Einfluss der Capping Triade der D-Domäne auf die cGMP-Affinität und Kinaseaktivität der cGMP-abhämgigen Proteinkinase von Plasmodium falciparum, (2017).
  • Rocker, D.: Herstellung und erste Charakterisierung des ROCCOR-Konstruktes von LRRK2, (2017).
  • Wollenhaupt, A.U.: Interaktion schwefelmodifizierter cAMP-Analoga mit isolierten cAMP-Bindedomänen der PKA Typ-II, (2016).
  • Seefeldt, N.K.: Entwicklung von Strategien zur Reinigung von humanen regulatorischen Untereinheiten der PKA, (2016).
  • Bodenstein, R.: Entwicklung eines PKA-basierten cGMP Biolumineszenz-Resonanz-Energie-Transfer (BRET) Sensors, (2016).
  • Friebe, S.: Dynamik der Phosphorylierung von LRRK2-S2525 durch PKA, (2016).
  • Koray, Ü.: Interaktionsanalysen der 14-3-3 Isoformen Sigma und Eta mit LRRK2-abgeleiteten Peptiden, (2016).
  • Gresing, L.J.: Bindungsstudien an DnaJB1-PRKACA - Einer pathogenen Chimäre aus PKA und HSP40, (2016).
  • Krimm, J.: Phosphorylierungsabhängige Interaktion von LRRK2 Peptiden an die 14-3-3 Isoformen Gamma und Eta, (2015).
  • Siemon, A.: Bindungsstudien an der D-Domäne der Proteinkinsae G aus Plasmodium falciparum, (2015).
  • da Silva Télinhos, D.S.: Interaktionsanalyse zwischen den 14-3-3-Isoformen Gamma und Epsilon und LRRK2 abgeleiteten Peptiden, (2015).
  • Weichert, D.: cGMP-Bindungsstudien an der regulatorischen Domäne der humanen Proteinkinase G Typ II, (2015).
  • Hatlauf, M.A.: Vergleichende Bindungsstudien an R-isoformspezifischen AKAP-Disruptoren, (2015).
  • Machal, E.: Vergleichende Untersuchungen zur Bindung der PKI-Isoformen α/β/γ an die katalytische Untereinheit der PKA, (2014).
  • Manschwetus, J.T.: Interaktionsanalysen zwischen der PKA-R-Untereinheit und 'stapled peptides' zur Identifizierung eines Isoform-spezifischen AKAP-Disruptors, (2014).
  • Stein, C.: Interaktionsanalyse zwischen 14-3-3 Proteinen und Peptiden, abgeleitet von Leucine-Rich-Repeat-Kinase 2 (LRRK2), (2014).
  • Tießen, M.: Metall-Nukleotid-Studien an PKA, (2013).
  • Schmidt, S.: Entwicklung einer neuartigen Sepharosematrix als biochemisches Werkzeug zur Herstellung fusionsanteilsfreier Proteine, (2012).
  • Breitenstein, H.: Funktionelle Charakterisierung von Domänenmotiven der Parkinson-assoziierten Proteinkinase LRRK2 (Leucine-rich repeat kinase 2), (2012).
  • Felgen, N.: Synthese und Charakterisierung eines dinuklearen Metall-Chelatkomplexes zur Analyse von Protein-Phosphoisoformen, (2012).

Conference Proceedings
  • Lorenz, R., Moon, E., Huang, G., Reger, A., Kim, J., Franz, E., Bertinetti, D., Kim, C., Herberg, F.: Transforming PKA into PKG - a structure-function approach to understand cyclic nucleotide selectivity. (2013).
  • Huang, G., Kim, J., Reger, A., Lorenz, R., Moon, E., Zhao, C., Casteel, D., Bertinetti, D., VanSchouwen, B., Selvaratnam, R., Pflugrath, J., Sankaran, B., Melacini, G., Herberg, F.W., Kim, C.: Structures of human PKG reveal cGMP-selectived activation mechanisms. (2013).
  • Skroblin, P., Hundsrucker, C., Christian, F., Zenn, H.M., Herberg, F.W., Rosenthal, W., Klussmann, E.: Identification of GSKIP as an AKAP. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. p. 116 (2009).
  • Szaszak, M., Christian, F., Lorenz, D., Furkert, J., Immig, H., Hampel, K., Zimmermann, B., Zenn, H.M., Herberg, F.W., von Kries, J.P., Rosenthal, W., Klussmann, E.: Inhibition of the interactions between protein kinase A and A kinase anchoring proteins in cardiac myocytes. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. p. 245 (2008).
  • Christian, F., Szaszak, M., Hampel, K., Lorenz, D., Furkert, J., Zenn, M., Zimmermann, B., Herberg, F.W., Rosenthal, W., Klussmann, E.: A small molecule for interference with compartmentalised cAMP signalling. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. p. 129 (2008).
  • Schweinsberg, S., Moll, D., Herberg, F.W.: Protein-ligand binding investigated by biomolecular Interaction Analysis (BIA). Presented at the , Berlin, Germany (2005).
  • Hundsrucker, C., Beyermann, M., Prinz, A., Zimmermann, B., Herberg, F.W., Krause, G., McSorley, T., Lorenz, D., Rosenthal, W., Klussmann, E.: Peptide disruptors of AKAP-PKA interactions. Naunyn-Schmiedebergs Archives of Pharmacology. pp. R52-R52 (2005).
  • Moll, D., Burghardt, N.C.G., Herberg, F.W.: Physico-chemical tools for functional characterization of protein-cyclic nucleotide interaction. Presented at the , Berlin, Germany (2005).
  • Prinz, A., Erlbruch, A., Herberg, F.W.: Monitoring cAMP dependent protein kinase subunit interaction in intact cells using bioluminescence resonance energy transfer (BRET). FASEB JOURNAL. pp. C-159-C160 Suppl. (2004).
  • Herberg, F.W., Thieleczek, R., jr. L.M.G., H.: Preparation and characterization of Myotome Membrane vesicles of branchiostoma Lanceolatum. In: Carraro, U. (ed.) Sarcomeric and Non-Sarcomeric Muscles: Basic applied research Prospects for the 90's. pp. 619-624. , Unipress Padova (1988).

Technical Notes
  • Neubauer, U., Bertinetti, D., Prinz, A., Herberg, F.W.: Proteine bei der Arbeit beobachten. Hessen-Biotech NEWS (2011).
  • Badel, A., Hanke, S.E., Herberg, F.W.: PKA, an All-rounder in Signal Transduction. G.I.T Laboratory Journal (2010).
  • Bertinetti, D., Herberg, F.W.: Biochemie: Das Bindungsverhalten von Proteinen - und was man damit anfangen kann. Wissen Schafft Anwendung (2009).
  • Hanke, S.E.: Proteomics Day 2008 in Rotenburg an der Fulda. Biospektrum (2008).
  • Prinz, A., Guske, K., Zimmermann, B.: Fluoreszenz- und Biolumineszenzmethoden in der Proteinanalytik. LABORWELT (2008).
  • Roth, S.E., Bertinetti, O., Herberg, F.W.: Die Masse macht’s! - Massenspektrometrie als interdisziplinäres Werkzeug. Bioforum (2008).
  • Müller, S., Kromke, M., Vogt, H., Bertinetti, D.: Enzymkinetik in der Schule. Biologie in unserer Zeit (2007).
  • Moll, D., Schweinsberg, S., Drewianka, S., Herberg, F.W.: Biomolekulare Interaktionsanalyse - Ein Werkzeug der funktionellen Proteomforschung? BIOforum (2006).
  • Diskar, M., Herberg, F.W., Prinz, A.: Quantifizierung intrazellulärer Protein-Protein-Wechselwirkungen. Biospektrum (2006).
  • Zimmermann, B.: Biologische Wechselwirkungen unter der Lupe. Deutsche Zeitschrift für Klinische Forschung (2005).
  • Lenz, C., Bertinetti, O., Herberg, F.W.: Complete Characterisation of the Phosphorylation Sites of Protein Kinase. Applied Biosystems technical note (2005).
  • Zeilinger, C., Herberg, F.W.: Chip Design für die Biomolekulare Interaktionsanalyse. Telekommunikation aktuell (2004).
  • Marcus, K., Hultschig, C., Frank, R., Herberg, F.W., Schuchardt, J., Seitz, H.: Innovative Forschungsansätze im NGFN Verbund "The Human Brain Proteome Project HBPP". GenomXPress (2003).
  • Lenz, C., Kruft, V., Herberg, F.W., Zeilinger, C.: Neue Strategien zur Analyse posttranslationaler Proteinmodifikationen auf einem hybriden Triple Quadrupol -Linearen Ionenfallen Massenspektrometer. Applied Biosystems technical note (2003).
  • Zimmermann, B., Hahnefeld, C., Herberg, F.W.: Applications of biomolecular interaction analysis in drug development. TARGETS (2002).
  • Zimmermann, B., Herberg, F.W.: Interactions of 6xHis-tagged protein kinase A catalytic subunit examined using Ni-NTA Magnetic Agarose Beads. Qiagen News (1998).
  • Jäger, W., Haase, B., Lutz, V., Herberg, F.W., Zimmermann, B.: Biomolekulare Interaktionsanalyse (BIA) mit SPR-Biosensortechnologie. Biospektrum (1997).
  • Herberg, F.W., Stefano, M.D.: High Speed Separation of Isozymes of Recombinant cAMP Dependent Protein Kinase Using UNO™ S1 and S6 Columns. BIORAD technical note (1997).