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Proteins
involved in endocytic transit of Dictyostelium
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Top: Vacuolin, a protein related to flotillin/reggie from vertebrates is a marker for late, neutral endosomes. | ||||
| Left: Fluid-phase-marker (red) reaches the GFP-vacuolin decorated endosome after one hour. | |||||
| Function: Cells lacking the gene encoding vacuolin B have a single giant neutral endosome and a prolonged transit of endocytic cargo. Vacuolin A mutants are phenotypically normal. Vacuolin has also been used to target cytoskeletal proteins to the late endosome to analyse the function of the actin coat (click here for more). | |||||
| References: Rauchenberger et al., 1997 Jenne et al., 1998 | |||||
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