Publications

Peer reviewed research articles

  1. Merker D, Kesper M, Kailing LL, Herberg FW, Reithmaier JP, Pavlidis IV, Popov C. Nanostructured modified ultrananocrystalline diamond surfaces as immobilization support for lipases. Diamond & Related Materials. 90 (2018) 32–39
  2. Espiard S, Knape MJ, Bathon K, Assié G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J. Activating PRKACB somatic mutation in cortisol-producing adenomas. JCI Insight. 2018 Apr 19;3(8). pii: 98296. doi: 10.1172/jci.insight.98296.
  3. Kailing LL, Bertinetti D, Paul CE, Manszewski T, Jaskolski M, Herberg FW, Pavlidis IV. S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic. Front Microbiol. 2018 Mar 21;9:505. doi: 10.3389/fmicb.2018.00505. eCollection 2018.
  4. Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T. PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination. J Cell Biol. 2018 Jun 4;217(6):2167-2184.doi: 10.1083/jcb.201708053
  5. Bendzunas NG, Dörfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg Med Chem. 2018 Feb 12. pii: S0968-0896(17)31514-6. doi: 10.1016/j.bmc.2018.02.001. [Epub ahead of print]
  6. Vighi E, Rentsch A, Henning P, Comitato A, Hoffmann D, Bertinetti D, Bertolotti E, Schwede F, Herberg FW, Genieser HG, Marigo V. New cGMP analogues restrain proliferation and migration of melanoma cells Oncotarget. 2017 Dec 25;9(4):5301-5320. doi: 10.18632/oncotarget.23685. eCollection 2018 Jan 12.PMID:29435180
  7. Franz E, Knape MJ, Herberg FW. cGMP binding domain D mediates a unique activation mechanism in Plasmodium falciparum PKG. ACS Infect Dis. 2018 Mar 9;4(3):415-423. doi: 10.1021/acsinfecdis.7b00222. Epub 2017 Dec 26.
  8. He D, Lorenz R, Kim C, Herberg FW, Lim CJ.  Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains. ACS Chem Biol. 2017 Nov 21. doi: 10.1021/acschembio.7b00732.
  9. Knape MJ, Ballez M, Burghardt NC, Zimmermann B, Bertinetti D, Kornev AP and Herberg FW Divalent metal ions control activity and inhibition of protein kinases Metallomics 2017 2017 Nov 15;9(11):1576-1584
  10. Pérez-Mendoza D, Bertinetti D, Lorenz R, Gallegos MT, Herberg FW, Sanjuán J. A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan. Sci Rep. 2017 Aug 21;7(1):8997. doi: 10.1038/s41598-017-09290-2.
  11.  Campbell JC, Henning P, Franz E, Sankaran B, Herberg FW, Kim C. Structural Basis of Analog Specificity in PKG I and II.ACS Chem Biol. 2017 Aug 9. doi: 10.1021/acschembio.7b00369.
  12. Kailing LL, Bertinetti D, Herberg FW, Pavlidis IV A coupled photometric assay for characterization of S-adenosyl-L-homocysteine hydrolases in the physiological hydrolytic direction. N Biotechnol. 2017 Apr 28. pii: S1871-6784(17)30111-5. doi: 10.1016/j.nbt.2017.04.005.
  13. Lorenz R, Moon, EW, Kim, JJ, Schmidt, SH, Sankaran, S, Pavlidis, IV, Kim, C, Herberg, FW, Mutations of PKA cyclic nucleotide binding domains reveal novel aspects of cyclic nucleotide selectivity Biochem J. 2017 Jul 6;474(14):2389-2403. doi: 10.1042/BCJ20160969
  14. Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. Eur J Pain. 2017 Feb 9. doi: 10.1002/ejp.1008.
  15. Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of PKG Iβ CNB-B:Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan;591(1):221-230. doi: 10.1002/1873-3468.12505. Epub 2016 Dec 23.
  16. Jamsari J, Ferita I, Noverta A, Dharma Husada E, Herberg FW, Nellen W and Syukriani L: A Pathogenic Isolate of Monopartite PepYLCV DNA A-like Genome Differs Significantly in C1 Gene and CR Sequence, but not in their other Genes Plant Pathol. J., 15 (4): 124-134, 2016
  17. Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18: PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA Biochem J. 2016 Apr 21. pii: BCJ20160242.
  18. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation Structure. 2016 Apr 5. pii: S0969-2126(16)00087-3. doi: 10.1016/j.str.2016.03.009. PMID: 27066748
  19. Kibat J, Schirrmann T, Knape MJ, Helmsing S, Meier D, Hust M, Schröder C, Bertinetti D, Winter G, Pardes K, Funk M, Vala A, Giese N, Herberg FW, Dübel S, Hoheisel JD. Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. N Biotechnol. 2016 Sep 25;33(5 Pt A):574-81. doi: 10.1016/j.nbt.2015.12.003.
  20. Autenrieth K, Bendzunas G, Bertinetti D, *Herberg FW, *Kennedy EJ.  Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI). Chembiochem. 2016 Apr 15;17(8):693-7. doi: 10.1002/cbic.201500632
  21. VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). J Biol Chem. 2015 290(48):28631-41 doi: 10.1074/jbc.M115.685305.
  22. Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch L, Herberg FW, Frank R, Häussler S. Application of synthetic peptide arrays to uncover c-di-GMP binding motifs. J Bacteriol. 2015 Aug 31. pii: JB.00377-15.
  23. Knape, MJ, Ahuja, LG, Bertinetti, D, Burghardt, NCG, Zimmermann, B, Taylor, SS, Herberg, FW Divalent metal ions Mg2+ and Ca2+ have distinct effects on protein kinase A activity and regulation ACS Chem Biol. 2015 Oct 16;10(10):2303-15. doi: 10.1021/acschembio.5b00271. Epub 2015 Aug 5.
  24. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, *Herberg FW, *Taylor SS. (2015) Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. PLoS Biol 13(7): e1002192. doi:10.1371/journal.pbio.1002192
  25. Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose- Stimulated Insulin Sekcretion .Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330
  26. Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW. “Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein” Biochim Biophys Acta. 2015 Apr 23. pii: S1570-9639(15)00115-6. doi: 10.1016/j.bbapap.2015.04.018.
  27. anoharan GB1, Enkvist E1, Kasari M1, Viht K1, Zenn M2, Prinz A2, Filhol O3, Herberg FW2, Uri A4.FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases  Analytical Biochemistry 2015 Apr 9. pii: S0003-2697(15)00155-4. doi: 10.1016/j.ab.2015.04.009.
  28. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Apr 3. pii: S1570-9639(15)00093-X. doi: 10.1016/j.bbapap.2015.03.012.
  29. Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ. “PKA-type I Selective Constrained Peptide Disruptors of AKAP Complexes” ACS Chem Biol. 2015 Jun 19;10(6):1502-10. doi: 10.1021/acschembio.5b00009. Epub 2015 Mar 25.
  30. Jamsari, Lily Syukriani, Hashlin Pascananda Utami, Friedrich Herberg, Wolfgang Nellen and Istino Ferita Injection Technique Could as a New Promising Method for Artificial Infection of Geminivirus Particles in Chili Pepper (Capsicum annuum L.) Asian J of Agriculture 9 (1) 23-32,  2015
  31. Kim JJ, Flueck C, Franz E, Sanabria-Figueroa E, Thompson E, Lorenz R, Bertinetti D, Baker DA, Herberg FW, Kim C. Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.PLoS Pathog. 2015 Feb 3;11(2):e1004639. doi: 10.1371/journal.ppat.1004639. eCollection.
  32. Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H. Structure-guided design of selective Epac1 and Epac2 agonists PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.
  33. Jamsari Jamsari, Istino Ferita, Lily Syukriani, Helni Lalan, Friedrich Herberg and Wolfgang Nellen The Existence of Two Distinct Whiteflies in Chilli-Pepper Cultivation in West Sumatra-Indonesia Based on Mitochondria Cytochrome Oxidase I Gene Sequences Asian Journal for Plant Pathology 2014
  34. Möller S, Alfieri A, Bertinetti D, Aquila M, Schwede F, Lolicato M, Rehmann H, Moroni A, Herberg FW. Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels ACS Chem Biol. 2014 May 16;9(5):1128-37. doi: 10.1021/cb400904s. Epub 2014 Mar 7.
  35. Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-Specific Disruption of AKAP-localized PKA Using Hydrocarbon Stapled Peptides ACS Chem Biol. 2014 Mar 21;9(3):635-42. doi: 10.1021/cb400900r. Epub 2014 Jan 21
  36. Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A, 2014. 111(1): p. E34-43.
  37. Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S. Trapping of Cyclin G associated kinase (GAK) Kinase Conformations using Nanobodies Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399.
  38. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C.,* Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG Structure. Structure. 2014 Jan 7;22(1):116-24. doi: 10.1016/j.str.2013.09.021. Epub 2013 Nov 14.
  39. Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, Allgöwer F, Herberg FW, Hucho T Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons J Cell Sci. 2014 Jan 1;127(Pt 1):216-29. doi: 10.1242/jcs.136580
  40. Du X, Barisch C, Paschke P, Herrfurth C, Bertinetti O, Pawolleck N, Otto H, Rühling H, Feussner I, Herberg FW, Maniak M. Dictyostelium lipid droplets host novel proteins. Eukaryot Cell. 2013 Nov;12(11):1517-29.
  41. Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG. Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag Mol Endocrinol. 2013, 1267-82.
  42. Kämpf, K., Kübler, S., Herberg, F.w., Ehresmann, A. Magneto-optic surface plasmon resonance optimum layers: Simulations for biological relevant refractive index changes J. Appl. Phys. 112, 034505 (2012); doi: 10.1063/1.4742130
  43. Kummer L, Parizek P, Rube P, Millgramm B, Prinz A, Mittl PR, Kaufholz M, Zimmermann B, Herberg FW, Plückthun A. Phosphorylation-specific ERK kinase-binders from designed ankyrin repeat protein libraries Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2248-57. doi: 10.1073/pnas.1205399109. Epub 2012 Jul 27
  44. Parizek P, Kummer L, Rube P, Prinz A, Herberg FW, Plückthun A.Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases ACS Chem Biol. 2012 Aug 17;7(8):1356-66. doi: 10.1021/cb3001167
  45. Søberg K, Larsen AC, Diskar M, Backe PH, Bjørås M, Jahnsen T, Laerdahl JK, Rognes T, Herberg FW, Skålhegg BS. Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA) . PLoS One. 2012;7(4):e34838. Epub 2012 Apr 13.
  46. Düvel J, Bertinetti D, Möller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jänsch L, Herberg FW, Häussler S. A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. J Microbiol Methods. 2012 Feb;88(2):229-36
  47. Lolicato M, Nardini M, Gazzarrini S, Moeller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A. Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels. J Biol Chem. 2011 Dec 30;286(52):44811-20.
  48. Vetter MM, Zenn HM, Méndez E, van den Boom H, Herberg FW, Skålhegg BS.The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA. BMC Biochem. 2011 Aug 3;12:40.
  49. Schmidt J, Müsken M, Becker T, Magnowska Z, Bertinetti D, Möller S, Zimmermann B, Herberg FW, Jänsch L, Häussler S. The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling.PLoS One. 2011 Mar 22;6(3):e18184
  50. Christian F, Szaszak M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Goetz F, Zuehlke K, Moutty M, Goettert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gaspar R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E. Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.J Biol Chem. 2011 Mar 18;286(11):9079-96. Epub 2010 Dec 22.
  51. Hanke SE, Bertinetti D, Badel A, Schweinsberg S, Genieser HG, Herberg FW Cyclic nucleotides as affinity tools: phosphorothioate cAMP analogues address specific PKA subproteomes. N Biotechnol. 2011 Jul;28(4):294-301. Epub 2010 Dec 13.
  52. Diskar M, Zenn HM, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, Berrera M, Zaccolo M, Boshart M, Herberg FW, Prinz A Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit {alpha}H-{alpha}I loop.J Biol Chem. 2010 Nov 12;285(46):35910-8. Epub 2010 Sep 6.
  53. Erlbruch A, Hung CW, Seidler J, Borrmann K, Gesellchen F, König N, Kübler D, Herberg FW, Lehmann WD, Bossemeyer D. Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics. 2010 Aug;10(16):2890-900.
  54. Hundsrucker, C., P. Skroblin, F. Christian, M. Zenn, V. Popara, M. Joshi, J. Eichhorst, B. Wiesner, F. W. Herberg, B. Reif, W. Rosenthal and E. Klussmann (2010). "Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem. 2010 Feb 19;285(8):5507-21. Epub 2009 Dec 11.
  55. Gloriam, D. E., S. Orchard, D. Bertinetti, E. Bjorling, E. Bongcam-Rudloff, J. Bourbeillon, A. R. Bradbury, A. de Daruvar, S. Dubel, R. Frank, T. J. Gibson, N. Haslam, F. W. Herberg, T. Hiltke, J. D. Hoheisel, S. Kerrien, M. Koegl, Z. Konthur, B. Korn, U. Landegren, S. van der Maarel, L. Montecchi-Palazzi, S. Palcy, H. Rodriguez, S. Schweinsberg, V. Sievert, O. Stoevesandt, M. J. Taussig, M. Uhlen, C. Wingren, L. Gold, P. Woollard, D. J. Sherman and H. Hermjakob (2010). Report: A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics. 2010 Jan;9(1):1-10. Epub 2009 Aug 11.
  56. Schluter, S., C. M. Franz, F. Gesellchen, O. Bertinetti, F. W. Herberg and F. R. Schmidt (2009). The high biofilm-encoding Bee locus: a second pilus gene cluster in Enterococcus faecalis? Curr Microbiol 59(2): 206-11.
  57. Viertlboeck, B. C., S. Schweinsberg, R. Schmitt, F. W. Herberg and T. W. Gobel (2009). The chicken leukocyte receptor complex encodes a family of different affinity FcY receptors. J Immunol 182(11): 6985-92.
  58. Wojtal, K. A., M. Diskar, F. W. Herberg, D. Hoekstra and S. C. van Ijzendoorn (2009). Regulatory Subunit I-controlled Protein Kinase A Activity Is Required for Apical Bile Canalicular Lumen Development in Hepatocytes. J Biol Chem 284(31): 20773-80.
  59. Prinz A, Herberg FW: UCSD-Nature Molecule Page PrKX. 2009
  60. Bertinetti, D., Schweinsberg, S., Hanke, S. E., Schwede, F., Bertinetti, O., Drewianka, S., Genieser, H. G., and Herberg, F. W. (2009). Chemical tools selectively target components of the PKA system. BMC Chem Biol 9, 3.
  61. Zimmermann B, Schweinsberg S, Drewianka S, Herberg FW: Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J 2008, 413(1):93-101.
  62. Collins DM, Murdoch H, Dunlop AJ, Charych E, Baillie GS, Herberg FW, Brandon N, Prinz A, Houslay MD: Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal. 2008 Dec;20(12):2356-69
  63. Moll D, Prinz A, Brendel CM, Berrera M, Guske K, Zaccolo M, Genieser HG, Herberg FW: Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog. BMC Biochem 2008, 9(1):18.
  64. Farquhar MJ, Harris HJ, Diskar M, Jones S, Mee CJ, Nielsen SU, Brimacombe CL, Molina S, Toms GL, Maurel P, Howl J, Herberg FW, van Ijzendoorn SC, Balfe P and McKeating JA:: Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. J Virol 2008, 82(17):8797-8811
  65. Hamacher, M., Herberg, F., Ueffing, M., and Meyer, H. E. (2008). Seven successful years of Omics research: The Human Brain Proteome Project within the National German Research Network (NGFN). Proteomics 8, 1116-1117
  66. Schweinsberg, S., Moll, D., Burghardt, N. C., Hahnefeld, C., Schwede, F., Zimmermann, B., Drewianka, S., Werner, L., Kleinjung, F., Genieser, H. G., Schuchhardt, J., Herberg, F. W. . (2008). Systematic interpretation of cyclic nucleotide binding studies using KinetXBase. Proteomics 8, 1212-1220.
  67. Ruppelt, A., Mosenden, R., Gronholm, M., Aandahl, E. M., Tobin, D., Carlson, C. R., Abrahamsen, H., Herberg, F. W., Carpen, O., and Tasken, K. (2007). Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol 179, 5159-5168.
  68. Diskar M, Zenn, H.M., Kaupisch, A., Prinz, A., Herberg, F.W.: Molecular basis for isoform specific autoregulation of protein kinase A - insights from the human catalytic subunit PrKX (2007) Cell Signal. 2007 Oct;19(10):2024-34.
  69. Viertlböck, B. C., Schweinsberg, S., Hanczaruk, M. A., Schmitt, R., Herberg, F. W., and Göbel, T. W. (2007). The chicken leukocyte receptor complex encodes a primordial, activating, high affinity IgY Fc receptor. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11718-23.
  70. Mirow, N., Zimmermann, B., Maleszka, A., Knobel, H., Tenderich, G., Koerfer, R., and Herberg, F. W. (2007). Plasma protein properties to immobilized heparin and heparin-albumin-conjugate. Artif Organs 31(6):466–471
  71. Hamacher, M., Stephan, C., Eisenacher, M., van Hall, A., Marcus, K., Martens, L., Park, Y. M., Gutstein, H. B., Herberg, F., and Meyer, H. E. (2007). Proteomics for everyday use: Activities of the HUPO Brain Proteome Project during the 5(th) HUPO World Congress. Proteomics 7, 1012-1015
  72. Moll, D., Schweinsberg, S., Hammann, C., and Herberg, F. W. (2007). Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A. Biol Chem 388, 163-172.
  73. Taussig, M. J.; Stoevesandt, O.; Borrebaeck, C. A.; Bradbury, A. R.; Cahill, D.; Cambillau, C.; de Daruvar, A.; Dubel, S.; Eichler, J.; Frank, R.; Gibson, T. J.; Gloriam, D.; Gold, L.; Herberg, F. W.; Hermjakob, H.; Hoheisel, J. D.; Joos, T. O.; Kallioniemi, O.; Koegl, M.; Konthur, Z.; Korn, B.; Kremmer, E.; Krobitsch, S.; Landegren, U.; van der Maarel, S.; McCafferty, J.; Muyldermans, S.; Nygren, P. A.; Palcy, S.; Pluckthun, A.; Polic, B.; Przybylski, M.; Saviranta, P.; Sawyer, A.; Sherman, D. J.; Skerra, A.; Templin, M.; Ueffing, M.; Uhlen, M. (2007). ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nature Methods 4, 13-17.
  74. Viht, K., Schweinsberg, S., Lust, M., Vaasa, A., Raidaru, G., Lavogina, D., Uri, A., and Herberg, F. W. (2007). Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase. Anal Biochem 362, 268-277.
  75. Stokka, A.J., Gesellchen, F., Carlson, C.R., Scott, J.D., Herberg, F.W., Tasken, K. (2006) Characterization of A-kinase-anchoring disruptors using a solution based assay. Biochem J. 400 (3), 493-499.
  76. Terrin, A., Di Benedetto, G., Pertegato, V., Cheung, Y. F., Baillie, G., Lynch, M. J., Elvassore, N., Prinz, A., Herberg, F. W., Houslay, M. D., and Zaccolo, M. (2006). PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol 175, 441-451.
  77. Hamacher, M.; Apweiler, R.; Arnold, G.; Becker, A.; Bluggel, M.; Carrette, O.; Colvis, C.; Dunn, M. J.; Frohlich, T.; Fountoulakis, M.; van Hall, A.; Herberg, F.; Ji, J.; Kretzschmar, H.; Lewczuk, P.; Lubec, G.; Marcus, K.; Martens, L.; Palacios Bustamante, N.; Park, Y. M.; Pennington, S. R.; Robben, J.; Stuhler, K.; Reidegeld, K. A.; Riederer, P.; Rossier, J.; Sanchez, J. C.; Schrader, M.; Stephan, C.; Tagle, D.; Thiele, H.; Wang, J.; Wiltfang, J.; Yoo, J. S.; Zhang, C.; Klose, J.; Meyer, H. E. The HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy Proteomics 6, 4890-4898.
  78. Gesellchen, F., Bertinetti, O., and Herberg, F. W. (2006a). Analysis of posttranslational modifications exemplified using protein kinase A. Biochim Biophys Acta 1764, 1788-1800.
  79. Moll, D., Gesellchen, F., Prinz, A., Drewianka, S., Zimmermann, B., and Herberg, F. W. (2006). Biomolecular interaction analysis in functional proteomics. J Neuronal Transmission 113, 1015-1032.
  80. Seitz, H., S. Hutschenreiter, C. Hultschig, C. Zeilinger, B. Zimmermann, F. Kleinjung, J. Schuchhardt, H. Eickhoff and F. W. Herberg (2006). Differential binding studies applying functional protein microarrays and surface plasmon resonance Proteomics 6, 5132-5139
  81. Gesellchen, F.; Prinz, A.; Zimmerman, B.; Herberg, F. (2006b) Quantification of cAMP antagonist action in vitro and in living cells. Eur J Cell Biol 85(7): 663-72.
  82. Prinz, A., M. Diskar, and F. Herberg, Application of Bioluminescence Resonance Energy Transfer (BRET) for biomolecular interaction studies. ChemBioChem, 2006 Chembiochem 7(7): 1007-1012
  83. Prinz, A.; Diskar, M.; Erlbruch, A.; Herberg, F.(2006) Novel, isotype-specific sensors for Protein Kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET). Cell Signal 18(10): 1616-25.
  84. Hundsrucker, C.; Krause, G.; Beyermann, M.; Prinz, A.; Zimmermann, B.; Diekmann, O.; Lorenz, D.; Stefan, E.; Nedvetsky, P.; Dathe, M.; Christian, F.; McSorley, T.; Krause, E.; McConnachie, G.; Herberg, F. W.; Scott, J. D.; Rosenthal, W.; Klussmann, E., (2006) High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A anchoring disruptor peptides. Biochem J.;396(2):297-306
  85. Ramanavicius, A.; Herberg, F. W.; Hutschenreiter, S.; Zimmermann, B.; Lapenaite, I.; Kaušaite, A.; Finkelšteinas, A.; Ramanavicien, A., Biomedical Application of Surface Plasmon Resonance Biosensors. Acta Medica Lithuania 2005, VOLUME 12, ( No. 3.), P. 1–9.
  86. Hahnefeld, C.; Moll, D.; Goette, M.; Herberg, F. W., Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA. Biol Chem 2005, 386, (7), 623-31.
  87. Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F. W., Valenti, G., Bachmann, S., Rosenthal, W. & Klussmann, E. (2004). Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem 279, 26654-65
  88. Thierse, H. J., Moulon, C., Allespach, Y., Zimmermann, B., Doetze, A., Kuppig, S., Wild, D., Herberg, F. & Weltzien, H. U. (2004). Metal-Protein Complex-Mediated Transport and Delivery of Ni(2+) to TCR/MHC Contact Sites in Nickel-Specific Human T Cell Activation. J Immunol 172, 1926-34.
  89. Gronholm, M., Vossebein, L., Carlson, C. R., Kuja-Panula, J., Teesalu, T., Alfthan, K., Vaheri, A., Rauvala, H., Herberg, F. W., Tasken, K. & Carpen, O. (2003). Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem 278, 41167-72
  90. Sichelschmidt, O. J., Hahnefeld, C., Hohlfeld, T., Herberg, F. W. & Schror, K. (2003). Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity. Cardiovasc Res 58(3), 602-610.
  91. Yaqub, S., Abrahamsen, H., Zimmerman, B., Kholod, N., Torgersen, K. M., Mustelin, T., Herberg, F. W., Tasken, K. & Vang, T. (2003). Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain. Biochem J 372(Pt 1), 271-8.
  92. Zimmermann, B., Hahnefeld, C. & Herberg, F. W. (2002). Applications of biomolecular interaction analysis in drug development. Targets Vol No. 2, 66-73.
  93. Carlson, C. R., Witczak, O., Vossebein, L., Labbe, J. C., Skalhegg, B. S., Keryer, G., Herberg, F. W., Collas, P. & Tasken, K. (2001). CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis. J Cell Sci 114(Pt 18), 3243-3254.
  94. Landsverk, H. B., Carlson, C. R., Steen, R. L., Vossebein, L., Herberg, F. W., Tasken, K. & Collas, P. (2001). Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis. J Cell Sci 114(Pt 18), 3255-64.
  95. Suer, S., Sickmann, A., Meyer, H. E., Herberg, F. W. & Heilmeyer, L. M. (2001). Human phosphatidylinositol 4-kinase isoform PI4K92 Expression of the recombinant enzyme and determination of multiple phosphorylation sites. Eur. J. Biochem. 268(7), 2099-106.
  96. Wang, X., Herberg, F. W., Laue, M. M., Wullner, C., Hu, B., Petrasch-Parwez, E. & Kilimann, M. W. (2000). Neurobeachin: A Protein Kinase A-Anchoring, beige/Chediak-Higashi Protein Homolog Implicated in Neuronal Membrane Traffic.    J Neurosci 20 (23), 8551-8565.
  97. Herberg, F. W., Maleszka, A., Eide, T., Vossebein, L. & Tasken, K. (2000). Analysis of A-Kinase Anchoring Protein (AKAP) Interaction with Protein Kinase A (PKA) Regulatory Subunits: PKA Isoform Specificity in AKAP Binding. J. Mol. Biol. 298 (2), 329-339.
  98. Herzog, A., Szegedi, C., Jona, I., Herberg, F.W., Varsanyi, M. (2000) Surface Plasmon Resonance studies prove the interaction of skeletal muscle sarcoplasmic reticular Ca2+ release channel/ryanodine receptor with calsequestrin. FEBS Letters 472, 73-77
  99. Toth, A., Kiss, E., Herberg, F. W., Gergely, P., Hartshorne, D. J. & Erdodi, F. (2000). Study of the subunit interactions in myosin phosphatase by surface plasmon resonance. Eur. J. Biochem. 267(6), 1687-1697.
  100. Herberg, F.W., Doyle, M., Cox, S. & Taylor, S.S. (1999) Dissection of the Nucleotide and Metal-Phosphate Binding Sites in cAMP-dependent Protein Kinase. Biochemistry 38 (19), 6352-60
  101. Zimmermann, B., Chiorini, J. Ma, Y., Kotin, R., and Herberg, F. (1999). PrKX is a Novel Catalytic Subunit of the cAMP-Dependent Protein Kinase regulated by the Regulatory Subunit Type I. J. Biol. Chem. 274:5370-5378
  102. Schliebs, W., Saidowski, J., Agianian, B., Dodt, G., Herberg, F. and Kunau, W. (1999) Recombinant Human PTS-1-Receptor PEX5: Structural Basis for Interaction of PEX5 with PEX14. J. Biol. Chem. 274:5666-5673
  103. Gehrmann, T., Gülkan, H., Suer S., Herberg F.W., Balla A., Vereb G., Mayr G.W., Heilmeyer L.M.G., Jr. (1999) Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230(1). Biochim Biophys Acta 1437:341-356
  104. Chiorini, J.A., Zimmermann, B., Yang, L., Smith, R.H., Ahearn, A., Herberg, F.W., Kotin, R.M. (1998) Inhibition of PrKX, a Novel Protein Kinase, and the cAMP-Dependent Protein Kinase PKA, by the Regulatory Proteins of Adeno-Associated Virus Type 2. Mol. Cell. Biol. 18, 5921-5929
  105. Reiffert, S. U., Jaquet, K., Heilmeyer jr., L. M. G. & Herberg, F. W. (1998) Stepwise Subunit Interaction Changes by Mono and Bisphosphorylation of Cardiac Troponin I. Biochemistry 37, 13516-13525.
  106. León, D., Herberg, F.W., Banky, P., and Taylor, S.S. (1997) A stable -Helical Domain at the N Terminus of the RIα Subunits of cAMP-dependent Protein Kinase Is a Novel Dimerization/Docking Motif. J. Biol. Chem. 272 (45), 28431-28437
  107. Herberg, F.W., Zimmermann, B., McGlone M.M. and Taylor, S.S. (1997) Importance of the A-helix of the catalytic subunit of the cAMP-dependent Protein kinase for stability and for orienting subdomains at the cleft interface.  Prot. Sci. 6 (3) 569-579
  108. Herberg, F.W., Taylor, S.S. and Dostmann, W.R.G.  (1996)  Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry   35 (9), 2934-42
  109. Wild, N., Herberg, F.W., Hofmann, F. and Dostmann, W.R.G. (1995) Expression of a chimeric cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I. FEBS  374 (3), 356-362
  110. Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, N-h, Taylor, S.S. and Varughese, K.I. (1995) Regulatory Subunit of  Protein Kinase A: Structure of a Deletion Mutant with cAMP Binding Domains Science 269: 807-813
  111. Herberg, F.W., Dostmann, W.R.G., Zorn, M., Davis, S.J. and Taylor, S.S. (1994) Crosstalk between Domains in the Regulatory Subunit of cAMP-dependent Protein Kinase: Influence of the Amino-Terminus of cAMP-binding and Holoenzyme Formation. Biochemistry 33:7485-7494
  112. Buechler, Y.J., Herberg, F.W. and Taylor, S.S. (1993) Regulation Defective Mutants of Type I cAMP-dependent Protein Kinase: Consequences of Replacing Arg94 and Arg95.  J. Biol. Chem.  268:16495-16503
  113. Herberg, F.W., Bell, S.M. and Taylor, S.S. (1993) Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase in E. coli: Multiple Isozymes Reflect Different Phosphorylation States. Prot. Eng.  6:771-777
  114. Herberg, F.W. and Taylor, S.S. (1993) Physiological Inhibitors of the Catalytic Subunit of cAMP-dependent Protein Kinase: Effect of MgATP on Protein/Protein Interaction.  Biochemistry  32:14015 -14022
  115. Benterbusch, R., Herberg, F.W., Melzer, W. Thieleczeck, R. (1992): Excitation-Contracting Coupling in a Pre-Vertebrate Twitch Muscle: The Myotomes of Branchiostoma lanceolatum. J. Membrane Biol. 129, 237-252.

 

Peer reviewed review articles

  1. Knape MJ and Herberg FW Metal coordination in kinases and pseudokinases Biochemical Society Transactions (2017) Jun 15;45(3):653-663. doi: 10.1042/BST20160327.
  2. Badel, A, Hanke, S and Herberg, FW: PKA: an Allrounder in Signal Transduction GIT 2010
  3. Roth S, Bertinetti O and Herberg F: Die Masse machts - Massenspektrometrie als interdisziplinäres Werkzeug. Bioforum 31: 30-32, 2008
  4. Diskar, M., F. W. Herberg and A. Prinz (2006). "Quantifizierung intrazellulärer Protein-Protein-Wechselwirkungen." Biospektrum 06: 629-631.
  5. Moll, D., et al., Biomolekulare Interaktionsanalyse - ein Werkzeug für die funktionelle Proteomforschung. Bioforum, 2006
  6. Moll, D., Zimmermann, B., Gesellchen, F. & Herberg, F. W. (2006c). Current developments for the in vitro characterization of protein interactions. In Proteomics in Drug Research (Marcus, K., Stühler, K., Warscheid, Hamacher, M., van Hall, A. & Meyer, H. E., eds.). Wiley-VCH, Weinheim. pp. 159-172.
  7. Gesellchen F, Zimmermann B and Herberg FW: (2005) Direct optical detection of protein-ligand interactions. Methods Mol Biol 305: 17-46,
  8. Hahnefeld, C., Drewianka, S. & Herberg, F. W. (2004). Determination of Kinetic Data Using Surface Plasmon Resonance Biosensors. Methods Mol Med, 299-320.
  9. Marcus, K., Hultschig, C., Frank, R., Herberg, F., Schuchhardt, J. & Seitz, H. (2003). Innovative Forschungsansätze im NGFN Verbund"The Human Brain Proteome Project HBPP". Genome Express 4.03; 5-8
  10. Herberg, F.W., and B. Zimmermann (1999). Analysis of protein kinase interactions using biomolecular interaction analysis. In PROTEIN PHOSPHORYLATION - A PRACTICAL APPROACH, D. G. Hardie, ed. (Oxford: Oxford University Press) 2nd ed. pp 335-71.
  11. Taylor, S., Radzio-Andzelm, E., Knighton, D., Eyck, L.T., Sowadski, J., Herberg, F., Yonemoto, W. and Zheng, J. (1993) Crystal Structures of the Catalytic Subunit of cAMP-Dependent Protein Kinase Reveal General Features of the Protein Kinase Family.  Receptor  3:165-172 (2,0)
  12. Taylor, S., Zheng, J., Radzio-Andzelm, E., Knighton, D., Eyck, L.T., Sowadski, J., Herberg, F. and Yonemoto, W. (1993) cAMP-Dependent Protein Kinase Defines a Family of Enzymes.  Phil. Trans. R. Soc. Lond. B. 340:315-324 (2,8)

 

Peer reviewed book chapters

  1. Lorenz R, Bertinetti D, Herberg FW. cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors. Handb Exp Pharmacol. 2017;238:105-122. doi: 10.1007/164_2015_36.
  2. Lorenz R, Hahnefeld C, Möller S, Bertinetti D and Herberg FW “Cyclic nucleotide analogs as chemical tools for interaction analysis” In: X. Cheng, editor, Cyclic Nucleotide Signaling, pages 203-23. CRC Press (2015)
  3. Eichler C, Herberg F, Schmidt F, Schaffrath R. (2013).  Does the bee locus encode an additional or alternative pilus in Enterococcus faecalis? In: Worldwide Research Efforts in the Fighting against Microbial Pathogens: From Basic Research to Technological Developments, Mendez-Vilas A (ed), BrownWalker Press (Boca Raton, FL, USA), pp. 134-138
  4. Zenn HM, Hutschenreiter S and Herberg FW Anti-Histidine Antibodies as Tools for Reversible  Capturing of His-Tagged Fusion Proteins for Subsequent Binding Analysis  in R. Kontermann and S. Dübel (eds.), Antibody Engineering, Chapter , 42DOI 10.1007/978-3-642-01144-3_42, # Springer-Verlag Berlin Heidelberg 2010 page 667-681
  5. Zeilinger, C. & Herberg, F. (2004). Chip Design für die Biomolekulare Interaktionsanalyse. Telekommunikation aktuell 58, 65-70
  6. Vossebein, L and Herberg, FW (2001). NATO/FEBS Advanced Study Institute on Protein Modules in Cellular Signaling, Le Hameau de l'Ètoile, St. Martin de Londres, France Multiplicity and Anchoring of PKA Isozymes Detected by Surface Plasmon Resonance NATO ASI Series A 313, 50 – 59
  7. Zimmermann, B., Klink, A., Rappolt, G., Herberg, F.W. (1997) Protein Kinase X: A Novel Human Protein Kinase related to the Catalytic Subunit of cAMP-dependent Protein Kinase. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 15-18
  8. Maleszka, A. and Herberg, F.W. (1997): Interaction Studies using Biosensors. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 27-36
  9. Reiffert, S., Jaquet, K, Heilmeyer, L.M.G., Herberg, F.W. (1997) Studies on the Function of Different Phosphoforms of Cardiac Troponin I. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 281-288
  10. Herberg, F.W., Yonemoto, W. and S.S. Taylor (1993): The Catalytic Subunit of cAMP-dependent Protein Kinase. in: Tyrosine Phosphorylation/ Dephosphorylation and Downstream Signalling NATO ASI Series: 203-213
  11. Herberg F.W., and S.S. Taylor (1991): Conformational and Shape Changes associated with cAMP-dependent Protein Kinase. Cellular Regulation by Protein Phosphorylation NATO ASI Series, Vol. H 59: 119-123.
  12. Taylor, S.S., Yonomoto, W., Dostmann, W., Knighton, D., Sowadski, J., Herberg, F., Buechler, J. and Y. Ji-Buechler (1991): Protein kinase Structure and Function: cAMP-dependent Protein Kinase. Cellular Regulation by Protein Phosphorylation NATO ASI Series, Vol. H 59:91-105.
  13. Herberg, F.W., Thieleczek, R and L.M.G. Heilmeyer Jr. (1988): Preparation and Characterization of Myotome Membrane Vesicles of Branchiostoma lanceolatum in: Sarcomeric and Non-Sarcomeric Muscles: Basic and Applied Research Prospects for the 90's, ed.: U. Carraro: 619-24.

 

Industry

  1. Langer A, Knape M and Herberg FW Hydrodynamic diameter and thermal stability measurements of protein inase A using switchSENSE Application note 2017
  2. Lenz, C.; Bertinetti, O.; Herberg, F. W., Complete Characterization of the Phosphorylation Sites of a Protein Kinase. Technical Note Applied Bosystems 2005
  3. Zimmermann, B., Herberg, F.W. (1998) Interactions of 6xHis-tagged protein kinase A catalytic subunit examined using Ni-NTA Magnetic agarose beads, QIAGEN NEWS (4) 1998, 9-10
  4. De Stefano, M., Herberg, F.W., Frey, R. (1998) Schnelle Trennung von Isoenzymen LaborPraxis 3 (22) 88 - 92
  5. Jaeger, W., Haase, B., Lutz, V., Herberg, F.W., Zimmermann, B. (1997) Biomolekulare Interaktionsanalyse (BIA) mit SPR-Biosensortechnologie Biospektrum 3 (4) 82-87