Publications

Peer Review Publications

2023

M. Rumpf, S. Pautz, B. Drebes, F. W. Herberg, and H.-A. Müller, “Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease,” International Journal of Molecular Sciences, vol. 24, no. 15, p. 11913, 2023.

http://dx.doi.org/10.3390/ijms241511913

2022

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, J. Zhang, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. Ruiz-Perez, X. Ge, G. Veglia, F. W. Herberg, S. S. Taylor, and B. R. Myers, “A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction,” Nature Structural & Molecular Biology, vol. 29, no. 10, pp. 990–999, 2022.

http://dx.doi.org/10.1038/s41594-022-00838-z
Y. Chen, L. Zizmare, V. Calbiague, S. Yu, F. W. Herberg, O. Schmachtenberg, F. Paquet-Durand, and C. Trautwein, “Retinal energy metabolism: Photoreceptors switch between Cori, Cahill, and mini-Krebs cycles to uncouple glycolysis from mitochondrial respiration,” bioRxiv. Cold Spring Harbor Laboratory, p. TBD, 2022.

http://dx.doi.org/10.1101/2022.06.20.496788
R. K. Singh, A. Soliman, G. Guaitoli, E. Störmer, F. Zweydorf, T. Dal Maso, A. Oun, L. van Rillaer, S. H. Schmidt, D. Chatterjee, J. A. David, E. Pardon, T. U. Schwartz, S. Knapp, E. J. Kennedy, J. Steyaert, F. W. Herberg, A. Kortholt, C. J. Gloeckner, and W. Versées, “Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2,” Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 9, pp. 1–12, 2022.

http://dx.doi.org/10.1073/pnas.2112712119
S. S. Taylor, K. Søberg, E. Kobori, J. Wu, S. Pautz, F. W. Herberg, and B. S. Skålhegg, “The Tails of Protein Kinase A,” Molecular pharmacology, vol. 101, no. 4, pp. 219–225, 2022.

http://dx.doi.org/10.1124/molpharm.121.000315
R. Sharma, J. J. Kim, L. Qin, P. Henning, M. Akimoto, B. Van Schouwen, G. Kaur, B. Sankaran, K. R. MacKenzie, G. Melacini, D. E. Casteel, F. W. Herberg, and C. Kim, “An auto-inhibited state of protein kinase G and implications for selective activation,” eLife, vol. 11, p. e79530, 2022.

http://dx.doi.org/10.7554/eLife.79530
J.-H. Weng, P. C. Aoto, R. Lorenz, J. Wu, S. H. Schmidt, J. T. Manschwetus, P. Kaila-Sharma, S. Silletti, S. Mathea, D. Chatterjee, S. Knapp, F. W. Herberg, and S. S. Taylor, “LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains,” PLoS Biology, vol. 20, no. 2, p. e3001427, 2022.

http://dx.doi.org/10.1371/journal.pbio.3001427
A. Pellegrino, S. Mükusch, V. Seitz, C. Steinbeck, J.-C. Steinmann, F. W. Herberg, and H. Seitz, “Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein,” Medical sciences (Basel, Switzerland), vol. 10, no. 4, pp. 1–16, 2022.

http://dx.doi.org/10.3390/medsci10040063
M. Ercu, M. B. Mücke, T. Pallien, L. Markó, A. Sholokh, C. Schächterle, A. Aydin, A. Kidd, S. Walter, Y. Esmati, B. J. McMurray, D. F. Lato, D. Yumi Sunaga-Franze, P. H. Dierks, B. I. M. Flores, R. Walker-Gray, M. Gong, C. Merticariu, K. Zühlke, M. Russwurm, T. Liu, T. U. P. Batolomaeus, S. Pautz, S. Schelenz, M. Taube, H. Napieczynska, A. Heuser, J. Eichhorst, M. Lehmann, D. C. Miller, S. Diecke, F. Qadri, E. Popova, R. Langanki, M. A. Movsesian, F. W. Herberg, S. K. Forslund, D. N. Müller, T. Borodina, P. G. Maass, S. Bähring, N. Hübner, M. Bader, and E. Klussmann, “Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage,” Circulation, vol. 146, no. 23, pp. 1758–1778, 2022.

http://dx.doi.org/10.1161/circulationaha.122.060210
L. G. Helton, H. J. Rideout, F. W. Herberg, and E. J. Kennedy, “Leucine rich repeat kinase 2 ( LRRK2 ) peptide modulators: Recent advances and future directions,” Peptide Science, vol. 114, no. 1, p. e24251, 2022.

http://dx.doi.org/10.1002/pep2.24251

2021

J.-H. Weng, P. C. Aoto, R. Lorenz, J. Wu, S. H. Schmidt, J. T. Manschwetus, P. Kaila-Sharma, S. Mathea, S. Knapp, F. W. Herberg, and S. S. Taylor, “Two helices control the dynamic crosstalk between the catalytic domains of LRRK2,” bioRxiv. p. TBD, 2021.

http://dx.doi.org/10.1101/2021.09.29.462278
D. J. Ramms, F. Raimondi, N. Arang, F. W. Herberg, S. S. Taylor, and J. S. Gutkind, “G\textgreekas-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant G\textgreekas-PKA Signaling,” Pharmacological reviews, vol. 73, no. 4, pp. 155–197, 2021.

http://dx.doi.org/10.1124/pharmrev.120.000269
F. Cuello, F. W. Herberg, K. Stathopoulou, P. Henning, and S. Diering, “Regulation of Cardiac PKA Signaling by cAMP and Oxidants,” Antioxidants, vol. 10, no. 5, pp. 1–26, 2021.

http://dx.doi.org/10.3390/antiox10050663
L. G. Helton, A. Soliman, F. Zweydorf, M. Kentros, J. T. Manschwetus, S. Hall, B. Gilsbach, F. J. Hock, P. S. Athanasopoulos, R. K. Singh, T. J. Le Clair, W. Versées, F. Raimondi, F. W. Herberg, C. J. Gloeckner, H. Rideout, A. Kortholt, and E. J. Kennedy, “Allosteric Inhibition of Parkinson’s-Linked LRRK2 by Constrained Peptides,” ACS Chemical Biology, vol. 16, no. 11, pp. 2326–2338, 2021.

http://dx.doi.org/10.1021/acschembio.1c00487
S. S. Taylor, M. Wallbott, E. M. F. Machal, K. Søberg, F. Ahmed, J. Bruystens, L. Vu, B. Baker, J. Wu, F. Raimondi, E. M. Ongeri, F. W. Herberg, and B. S. Skålhegg, “PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies,” Biochemical Journal, vol. 478, no. 11, pp. 2101–2119, 2021.

http://dx.doi.org/10.1042/BCJ20200867
J. Huang, J. A. Byun, B. Van Schouwen, P. Henning, F. W. Herberg, C. Kim, and G. Melacini, “Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G,” The journal of physical chemistry. B, vol. 125, no. 24, pp. 6532–6542, 2021.

http://dx.doi.org/10.1021/acs.jpcb.1c03622
E. Lasonder, K. More, S. Singh, M. Haidar, D. Bertinetti, E. J. Kennedy, F. W. Herberg, A. A. Holder, G. Langsley, and C. E. Chitnis, “cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Plasmodium falciparum Blood Stages,” Frontiers in Microbiology, vol. 12, pp. 1–15, 2021.

http://dx.doi.org/10.3389/fmicb.2021.684005
R. Lorenz, J. Wu, F. W. Herberg, S. S. Taylor, and R. A. Engh, “Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics,” Biochemistry, vol. 60, no. 46, pp. 3470–3484, 2021.

http://dx.doi.org/10.1021/acs.biochem.1c00359
S. H. Schmidt, J.-H. Weng, P. C. Aoto, D. Boassa, S. Mathea, S. Silletti, J. Hu, M. Wallbott, E. A. Komives, S. Knapp, F. W. Herberg, and S. S. Taylor, “Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2,” Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 23, p. e2100844118, 2021.

http://dx.doi.org/10.1073/pnas.2100844118
M. Reginka, H. Hoang, Ö. Efendi, M. Merkel, R. Huhnstock, D. Holzinger, K. Dingel, B. Sick, D. Bertinetti, F. W. Herberg, and A. Ehresmann, “Transport efficiency of biofunctionalized magnetic particles tailored by surfactant concentration,” Langmuir, vol. 37, no. 28, pp. 8498–8507, 2021.

http://dx.doi.org/10.1021/acs.langmuir.1c00900
A. Tolone, W. Haq, A. Fachinger, A. Rentsch, F. W. Herberg, F. Schwede, and F. Paquet-Durand, “Retinal degeneration: Multilevel protection of photoreceptor and ganglion cell viability and function with the novel PKG inhibitor CN238,” bioRxiv. p. TBD, 2021.

http://dx.doi.org/10.1101/2021.08.05.455191

2020

J. Byun, K. Van, J. Huang, P. Henning, E. Franz, M. Akimoto, F. W. Herberg, C. Kim, and G. Melacini, “Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase,” The Journal of biological chemistry, vol. 295, no. 25, pp. 8480–8491, 2020.

http://dx.doi.org/10.1074/jbc.RA120.013070
J. T. Manschwetus, M. Wallbott, A. Fachinger, C. Obergruber, S. Pautz, D. Bertinetti, S. H. Schmidt, and F. W. Herberg, “Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2,” Frontiers in Neuroscience, vol. 14, p. 302, 2020.

http://dx.doi.org/10.3389/fnins.2020.00302
O. Nonga, E. Enkvist, F. W. Herberg, and A. Uri, “Inhibitors and fluorescent probes for protein kinase PKAc extgreekb and its S54L mutant, identified in a patient with cortisol producing adenoma,” Bioscience, biotechnology, and biochemistry, vol. 84, no. 9, pp. 1839–1845, 2020.

http://dx.doi.org/10.1080/09168451.2020.1772038
C. Martin, L. Hering, N. Metzendorf, S. Hormann, S. Kasten, S. Fuhrmann, A. Werckenthin, F. W. Herberg, M. Stengl, and G. Mayer, “Analysis of Pigment-Dispersing Factor Neuropeptides and Their Receptor in a Velvet Worm,” Frontiers in endocrinology, vol. 11, p. 273, 2020.

http://dx.doi.org/10.3389/fendo.2020.00273
M. Knape, M. Wallbott, N. G. Burghardt, D. Bertinetti, J. Hornung, S. Schmidt, R. Lorenz, and F. W. Herberg, “Molecular Basis for Ser/Thr Specificity in PKA Signaling,” Cells, vol. 9, no. 6, p. 1548, 2020.

http://dx.doi.org/10.3390/cells9061548
S. Taylor, P. Kaila-Sharma, J.-H. Weng, P. Aoto, S. Schmidt, S. Knapp, S. Mathea, and F. W. Herberg, “Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery,” Frontiers in molecular neuroscience, vol. 13, p. 538219, 2020.

http://dx.doi.org/10.3389/fnmol.2020.538219
A. Palencia-Campos, P. Aoto, E. M. F. Machal, A. Rivera-Barahona, P. Soto-Bielicka, D. Bertinetti, B. Baker, L. Vu, F. Piceci-Sparascio, I. Torrente, E. Boudin, S. Peeters, W. van Helden, C. Huber, D. Bonneau, M. S. Hildebrand, M. Coleman, M. Bahlo, M. Bennett, A. Schneider, I. Scheffer, M. Kibæk, B. S. Kristiansen, M. Y. Issa, M. Mehrez, S. Ismail, J. Tenorio, G. Li, B. Skålhegg, G. Otaify, S. Temtamy, M. Aglan, A. E. Jønch, A. Luca, G. Mortier, V. Cormier-Daire, A. Ziegler, M. Wallis, F. W. Herberg, P. Lapunzina, S. S. Taylor, and V. L. Ruiz-Perez, “Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome,” American Journal of Human Genetics, vol. 107, no. 5, pp. 977–988, 2020.

http://dx.doi.org/10.1016/j.ajhg.2020.09.005

2019

M. Lelle, M. Otte, S. Thon, D. Bertinetti, F. W. Herberg, and K. Benndorf, “Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3’,5’-cyclic monophosphate derivatives,” Bioorganic & medicinal chemistry, vol. 27, no. 8, pp. 1704–1713, 2019.

http://dx.doi.org/10.1016/j.bmc.2019.03.024
F. W. Herberg, J. T. Manschwetus, G. N. Bendzunas, A. Limaye, M. J. Knape, and E. J. Kennedy, “A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A,” Molecules, vol. 24, no. 8, p. 1567, 2019.

http://dx.doi.org/10.3390/molecules24081567
B. Flaherty, T. Ho, S. Schmidt, F. W. Herberg, D. Peterson, and E. Kennedy, “Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 with a Constrained J Domain-Derived Disruptor Peptide,” ACS infectious diseases, vol. 5, no. 4, pp. 506–514, 2019.

http://dx.doi.org/10.1021/acsinfecdis.8b00347
S. H. Schmidt, M. J. Knape, D. Boassa, N. Mumdey, A. P. Kornev, M. Ellisman, S. S. Taylor, and F. W. Herberg, “The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFG extgreeky motif in the kinase domain,” Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 30, pp. 14979–14988, 2019.

http://dx.doi.org/10.1073/pnas.1900289116

2018

S. Espiard, M. Knape, K. Bathon, G. Assié, M. Rizk-Rabin, S. Faillot, W. Luscap-Rondof, D. Abid, L. Guignat, D. Calebiro, F. W. Herberg, C. A. Stratakis, and J. Bertherat, “Activating PRKACB somatic mutation in cortisol-producing adenomas,” JCI insight, vol. 3, no. 8, p. e98296, 2018.

http://dx.doi.org/10.1172/jci.insight.98296
E. Vighi, A. Rentsch, P. Henning, A. Comitato, D. Hoffmann, D. Bertinetti, E. Bertolotti, F. Schwede, F. W. Herberg, H.-G. Genieser, and V. Marigo, “New cGMP analogues restrain proliferation and migration of melanoma cells,” Oncotarget, vol. 9, no. 4, pp. 5301–5320, 2018.

http://dx.doi.org/10.18632/oncotarget.23685
D. Merker, M. Kesper, L. L. Kailing, F. W. Herberg, J. P. Reithmaier, I. V. Pavlidis, and C. Popov, “Nanostructured modified ultrananocrystalline diamond surfaces as immobilization support for lipases,” Diamond and Related Materials, vol. 90, pp. 32–39, 2018.

http://dx.doi.org/10.1016/j.diamond.2018.09.027
N. G. Bendzunas, S. Dörfler, K. Autenrieth, D. Bertinetti, E. M. F. Machal, E. J. Kennedy, and F. W. Herberg, “Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2,” Bioorganic & medicinal chemistry, vol. 26, no. 6, pp. 1174–1178, 2018.

http://dx.doi.org/10.1016/j.bmc.2018.02.001
J. Isensee, M. Kaufholz, M. J. Knape, J. Hasenauer, H. Hammerich, H. Gonczarowska-Jorge, R. P. Zahedi, F. Schwede, F. W. Herberg, and T. Hucho, “PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination,” The Journal of cell biology, vol. 217, no. 6, pp. 2167–2184, 2018.

http://dx.doi.org/10.1083/jcb.201708053
L. L. Kailing, D. Bertinetti, C. E. Paul, T. Manszewski, M. Jaskolski, F. W. Herberg, and I. V. Pavlidis, “S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic,” Frontiers in Microbiology, vol. 9, p. 505, 2018.

http://dx.doi.org/10.3389/fmicb.2018.00505

2017

M. Knape, M. Ballez, N. Burghardt, B. Zimmermann, D. Bertinetti, A. P. Kornev, and F. W. Herberg, “Divalent metal ions control activity and inhibition of protein kinases,” Metallomics, vol. 9, no. 11, pp. 1576–1584, 2017.

http://dx.doi.org/10.1039/c7mt00204a
E. Franz, M. Knape, and F. W. Herberg, “cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG,” ACS infectious diseases, vol. 4, no. 3, pp. 415–423, 2017.

http://dx.doi.org/10.1021/acsinfecdis.7b00222
J. C. Campbell, P. Henning, E. Franz, B. Sankaran, F. W. Herberg, and C. Kim, “Structural Basis of Analog Specificity in PKG I and II,” ACS Chemical Biology, vol. 12, no. 9, pp. 2388–2398, 2017.

http://dx.doi.org/10.1021/acschembio.7b00369
J. Peter, C. Kasper, M. Kaufholz, R. Buschow, J. Isensee, T. Hucho, F. W. Herberg, F. Schwede, C. Stein, S.-E. Jordt, M. Brackmann, and V. Spahn, “Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons,” European Journal of Pain, vol. 21, no. 6, pp. 1072–1086, 2017.

http://dx.doi.org/10.1002/ejp.1008
D. Perez-Mendoza, D. Bertinetti, R. Lorenz, M.-T. Gallegos, F. W. Herberg, and J. Sanjuan, “A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage beta-glucan,” Scientific reports, vol. 7, no. 1, p. 8997, 2017.

http://dx.doi.org/10.1038/s41598-017-09290-2
D. He, R. Lorenz, C. Kim, F. W. Herberg, and C. J. Lim, “Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains,” ACS Chemical Biology, vol. 12, no. 12, pp. 3057–3066, 2017.

http://dx.doi.org/10.1021/acschembio.7b00732
J. C. Campbell, B. Van Schouwen, R. Lorenz, B. Sankaran, F. W. Herberg, G. Melacini, and C. Kim, “Crystal structure of cGMP-dependent protein kinase Ibeta cyclic nucleotide-binding-B domain: Rp-cGMPS complex reveals an apo-like, inactive conformation,” FEBS Letters, vol. 591, no. 1, pp. 221–230, 2017.

http://dx.doi.org/10.1002/1873-3468.12505
R. Lorenz, E.-W. Moon, J. J. Kim, S. Schmidt, B. Sankaran, I. Pavlidis, C. Kim, and F. W. Herberg, “Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity,” Biochemical Journal, vol. 474, no. 14, pp. 2389–2403, 2017.

http://dx.doi.org/10.1042/BCJ20160969
L. L. Kailing, D. Bertinetti, F. W. Herberg, and I. Pavlidis, “A coupled photometric assay for characterization of S-adenosyl-L-homocysteine hydrolases in the physiological hydrolytic direction    ,” New Biotechnology, vol. 39, pp. 11–17, 2017.

http://dx.doi.org/10.1016/j.nbt.2017.04.005
M. J. Knape and F. W. Herberg, “Metal coordination in kinases and pseudokinases,” Biochemical Society Transactions, vol. 45, no. 3, pp. 653–663, 2017.

http://dx.doi.org/10.1042/BST20160327
R. Lorenz, D. Bertinetti, and F. W. Herberg, “cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors,” Handbook of Experimental Pharmacology, vol. 238, pp. 105–122, 2017.

http://dx.doi.org/10.1007/164_2015_36

2016

A. M. Knight, F. W. Herberg, A. Nobili, T. van den Bergh, M. Genz, H.-J. Joosten, D. Albrecht, K. Riedel, I. Pavlidis, and U. T. Bornscheuer, “Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases,” Applied Microbiology and Biotechnology, pp. 1–9, 2016.

http://dx.doi.org/10.1007/s00253-016-7940-7
M. Kilisch, O. Lytovchenko, E. C. Arakel, D. Bertinetti, B. Schwappach, and F. W. Herberg, “A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1,” Journal of Cell Science, vol. 129, no. 4, pp. 831–842, 2016.

http://dx.doi.org/10.1242/jcs.180182
K. Autenrieth, N. G. Bendzunas, D. Bertinetti, F. W. Herberg, and E. J. Kennedy, “Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI),” ChemBioChem, vol. 17, no. 8, pp. 693–697, 2016.

http://dx.doi.org/10.1002/cbic.201500632
F. W. Herberg, T. Tan, I. Pavlidis, Y. Tao, R. Dong, and B. Chen, “Using imidazolium-based ionic liquids as dual solvent- catalysts for sustainable synthesis of vitamin esters: inspiration from bio- and organo-catalysis,” Green Chemistry, vol. 18, pp. 1240–1248, 2016.

http://dx.doi.org/10.1039/c5gc02557e
M. S. Weiß, I. Pavlidis, P. Spurr, S. P. Hanlon, B. Wirz, H. Iding, U. T. Bornscheuer, and F. W. Herberg, “Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine,” Organic and Biomolecular Chemistry, vol. 14, no. 43, pp. 10249–10254, 2016.

http://dx.doi.org/10.1039/C6OB02139E
F. Götz, Y. Roske, M. S. Schulz, K. Autenrieth, D. Bertinetti, K. Faelber, K. Zühlke, A. Kreuchwig, E. J. Kennedy, G. Krause, O. Daumke, F. W. Herberg, U. Heinemann, and E. Klussmann, “AKAP18:PKA-RIIa structure reveals crucial anchor points for recognition of regulatory subunits of PKA,” Biochemical Journal, vol. 473, no. 13, pp. 1881–1894, 2016.

http://dx.doi.org/10.1042/BCJ20160242
A. Jamsari, I. Ferita, A. Noverta, E. D. Husada, F. W. Herberg, W. Nellen, and L. Syukriani, “A Pathogenic Isolate of Monopartite PepYLCV DNA A-like Genome Differs Significantly in C1 Gene and CR Sequence, but not in their other Genes,” Plant Pathology, vol. 15, pp. 124–134, 2016.
U. T. Bornscheuer, I. Pavlidis, D. Last, J. Müller, E. J. Moldenhauer, A. W. H. Dawood, and F. W. Herberg, “Highly efficient and easy protease-mediated protein purification,” Applied Microbiology and Biotechnology, vol. 100, pp. 1945–1953, 2016.

http://dx.doi.org/10.1007/s00253-015-7206-9
J. C. Campbell, B. VanSchouwen, R. Lorenz, B. Sankaran, F. W. Herberg, G. Melacini, and C. Kim, “Crystal structure of PKG Iß CNB-B:Rp-cGMPS complex reveals an apo-like, inactive conformation,” FEBS Letters, p. TBD, 2016.

http://dx.doi.org/10.1002/1873-3468.12505
J. J. Kim, R. Lorenz, S. T. Arold, A. S. Reger, B. Sankaran, D. E. Casteel, F. W. Herberg, and C. Kim, “Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation,” Structure, vol. 24, no. 5, pp. 710–720, 2016.

http://dx.doi.org/10.1016/j.str.2016.03.009
Q. Tang, G. M. Popowicz, X. Wang, J. Liu, I. Pavlidis, Y. Wang, and F. W. Herberg, “Lipase-driven epoxidation is a two-stage synergistic process,” Chemistry Select, vol. 1, no. 4, pp. 836–839, 2016.
I. Pavlidis, M. S. Weiß, M. Genz, P. Spurr, S. Hanlon, B. Wirz, H. Iding, U. T. Bornscheuer, U. T. B. H. Iding, and F. W. Herberg, “Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines,” Nature Chemistry, vol. n/a, no. n/a, p. DOI:10.1038/NCHEM.2578, 2016.
D. S. Da Silva Telinhos, M. Reginka, I. Koch, D. Holzinger, O. Bertinetti, D. Bertinetti, A. Ehresmann, F. W. Herberg, and I. Pavlidis, “Novel click-chemistry immobilization approach enables direct in situ monitoring of immobilization quality and yield,” in 67. Mosbacher Kolloquium, 67. Mosbacher Kolloquium, Ed. Mosbach: 67. Mosbacher Kolloquium, 2016, pp. 0–20.

2015

G. B. Manoharan, E. Enkvist, M. Kasari, K. Viht, H.-M. Zenn, A. Prinz, O. Filhol, F. W. Herberg, and A. Uri, “FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases,” Analytical Biochemistry, vol. 481, pp. 10–17, 2015.

http://dx.doi.org/10.1016/j.ab.2015.04.009
S. Mohanty, E. J. Kennedy, F. W. Herberg, R. Hui, S. S. Taylor, G. Langsley, and N. Kannan, “Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design,” BBA - Biochimica et Biophysica Acta, vol. 2015, no. 10, pp. 1575–1585, 2015.

http://dx.doi.org/10.1016/j.bbapap.2015.03.012
E. Franz, J. J. Kim, S. Olga, D. Bertinetti, C. Kim, and F. W. Herberg, “The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase,” in Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications, J.-P. Stasch, J. Burnett, H. Schmidt, M. Kuhn, and F. Hofmann, Eds. United Kingdom: BioMed Central Ltd., 2015, p. TBD.

http://dx.doi.org/10.1186/2050-6511-16-S1-A51
R. Lorenz, D. He, C. Kim, C. J. Lim, and F. W. Herberg, “Rational design of a PKA-based sensor for cGMP,” BMC pharmacology & Toxicology, vol. 16, no. S1, p. TBD, 2015.

http://dx.doi.org/10.1186/2050-6511-16-s1-a64
J. Düvel, S. Bense, S. Möller, S. Möller, D. Bertinetti, F. Schwede, M. Morr, D. Eckweiler, H.-G. Genieser, L. Jänsch, F. W. Herberg, R. Frank, and S. Häussler, “Application of synthetic peptide arrays to uncover c-di-GMP binding motifs,” Journal of Bacteriology, vol. 198, no. 1, pp. 138–146, 2015.

http://dx.doi.org/\url{10.1128/JB.00377-15}
J. Jamsari, L. Syukriani, H. P. Utami, F. W. Herberg, W. Nellen, and I. Ferita, “Injection Technique Could as a New Promising Method for Artificial Infection of Geminivirus Particles in Chili Pepper (Capsicum annuum L.),” Asian Journal of Plant Pathology, vol. 9, no. 1, pp. 23–32, 2015.
R. Lorenz, C. Hahnefeld, S. Moeller, D. Bertinetti, and F. W. Herberg, “Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways,” in Cyclic Nucleotide Signaling, X. Cheng, Ed. Boca Raton, Florida, Vereinigte Staaten: CRC Press, 2015, pp. 203–23.
Y. Wang, T. G. Ho, E. Franz, J. Hermann, F. D. Smith, H. Hehnly, J. L. Esseltine, L. E. Hanold, M. M. Murph, D. Bertinetti, J. D. Scott, F. W. Herberg, and E. J. Kennedy, “PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes,” ACS Chemical Biology, vol. 10, pp. 1502–1510, 2015.

http://dx.doi.org/10.1021/acschembio.5b00009
F. Schwede, O. G. Chepurny, M. Kaufholz, D. Bertinetti, C. A. Leech, O. Cabrera, Y. Zhu, F. Mei, X. Cheng, J. E. M. Fox, P. E. MacDonald, H.-G. Genieser, F. W. Herberg, and G. G. Holz, “Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion,” Molecular Endocrinology -Baltimore-, vol. 29, pp. 988–1005, 2015.

http://dx.doi.org/10.1210/me.2014-1330
M. Knape, L. G. Ahuja, D. Bertinetti, N. Burghardt, B. Zimmermann, S. S. Taylor, and F. W. Herberg, “Divalent Metal Ions Mg2+ and Ca2+ Have Distinct Effects on Protein Kinase A Activity and Regulation,” ACS Chemical Biology, vol. 10, pp. 2303–2315, 2015.

http://dx.doi.org/10.1021/acschembio.5b00271
B. van Schouwen, R. Selvaratnam, R. Giri, R. Lorenz, R. Lorenz, F. W. Herberg, C. Kim, and G. Melacini, “Mechanism of cAMP Partial Agonism in Preotein Kinase G (PKG),” Journal of Biological Chemistry, vol. 290, no. 48, pp. 28631–28641, 2015.

http://dx.doi.org/10.1074/jbc.M115.685305
P. Zhang, M. Knape, L. G. Ahuja, M. M. Keshwani, C. C. King, M. Sastri, F. W. Herberg, and S. S. Taylor, “Single Turnover Autophosphorylation Cycle of the PKA RIIbeta Holoenzyme,” PLoS Biology, vol. 13, no. 7, p. e1002192, 2015.
J. J. Kim, C. Flueck, E. Franz, E. Sanabria-Figueroa, E. Thompson, R. Lorenz, D. Bertinetti, D. A. Baker, F. W. Herberg, and C. Kim, “Crystal Structures of the carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress,” PLoS Pathogens, p. erscheint, 2015.
F. Schwede, D. Bertinetti, C. N. Langerijs, M. A. Hadders, H. Wienk, J. H. Ellenbroek, E. J. P. de Koning, J. L. Bos, F. W. Herberg, H.-G. Genieser, R. A. J. Janssen, and H. Rehmann, “Structure-guided design of selective Epac1 and Epac2 agonists,” PLoS Biology, p. erscheint, 2015.
J. Hermann, P. Skroblin, D. Bertinetti, D. Bertinetti, E. K. von der Heide, E.-M. Wagener, H.-M. Zenn, E. Klussmann, E. J. Kennedy, and F. W. Herberg, “Neurochondrin is an atypical RII alpha-specific A-kinase anchoring protein,” BBA - Proteins and Proteomics, vol. 1854, no. 10, pp. 1667–1675, 2015.

http://dx.doi.org/10.1016/j.bbapap.2015.04.018

2014

G. Huang, J. Kim, A. Reger, R. Lorenz, E. Moon, C. Zhao, D. E. Casteel, D. Bertinetti, B. van Schouwen, R. Selvaratnam, J. W. Pflugrath, B. Sankaran, G. Melacini, F. W. Herberg, and C. Kim, “Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I,” Structure, vol. 22, pp. 116–124, 2014.

http://dx.doi.org/10.1016/j.str.2013.09.021
A. Chaikuad, T. Keates, C. Vincke, M. Kaufholz, H.-M. Zenn, B. Zimmermann, C. Gutiérrez, R. Zhang, C. Hatzos-Skintges, A. Joachimiak, S. Muyldermans, F. W. Herberg, S. Knapp, and S. Müller, “Structure of Cyclin G associated kinase (GAK) Trapped in different Conformations using Nanobodies,” Biochemical Journal, vol. 459, pp. 59–69, 2014.

http://dx.doi.org/10.1042/BJ20131399
J. Isensee, M. Diskar, S. Waldherr, R. Buschow, J. Hasenauer, A. Prinz, F. Allgoewer, F. W. Herberg, and T. Hucho, “Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons,” Journal of Cell Science, vol. 127, pp. 216–229, 2014.

http://dx.doi.org/10.1242/jcs.136580
K. Muda, D. Bertinetti, F. Gesellchen, J. Hermann, F. von Zweydorf, A. Geerlof, A. Jacobs, M. Ueffing, C. J. Gloeckner, and F. W. Herberg, “The Parkinson related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3,” Proceedings of the National Academy of Sciences, vol. 111, no. 111, pp. E34–43, 2014.

http://dx.doi.org/10.1073/pnas.1312701111
Y. Wang, T. G. Ho, D. Bertinetti, M. Neddermann, E. Franz, G. C. H. Mo, L. P. Schendowich, A. Sukhu, R. C. Spelts, J. Zhang, F. W. Herberg, and E. J. Kennedy, “Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides,” ACS Chemical Biology, vol. 9, no. 6, p. 1386, 2014.

http://dx.doi.org/10.1021/cb500329z
Y. Wang, T. G. Ho, D. Bertinetti, M. Neddermann, E. Franz, G. C. H. Mo, L. P. Schendowich, A. Sukhu, R. C. Spelts, J. Zhang, F. W. Herberg, and E. J. Kennedy, “Isoform-Selective Disruption of AKAP-localized PKA Using Hydrocarbon Stapled Peptides,” ACS Chemical Biology, vol. 9, pp. 635–42, 2014.

http://dx.doi.org/10.1021/cb400900r
A. Jamsari, I. Ferita, L. Syukriani, H. Lalan, F. W. Herberg, and W. Nellen, “Existence of Two Distinct Whiteflies in Chilli-Pepper Cultivation in West Sumatra-Indonesia Based on Mitochondria Cytochrome Oxidase I Gene Sequences,” Asian Journal of Plant Pathology, vol. 8, pp. 34–44, 2014.
S. Möller, A. Alfieri, D. Bertinetti, M. Aquila, F. Schwede, M. Lolicato, H. Rehmann, A. Moroni, and F. W. Herberg, “Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels,” ACS Chemical Biology, vol. 9, pp. 1128–1137, 2014.

http://dx.doi.org/10.1021/cb400904s

2013

C. Eichler, F. W. Herberg, F. Schmidt, and R. Schaffrath, “Does the bee locus encode an additional or alternative pilus in Enterococcus faecalis?,” in Worldwide Research Efforts in the Fighting against Microbial Pathogens: From Basic Research to Technological Developments, A. Mendez-Vilas, Ed. Boca Raton, FL, USA: BrownWalker Press, 2013, pp. 134–138.
O. G. Chepurny, D. Bertinetti, M. Diskar, C. A. Leech, P. Afshari, T. Tsalkova, X. Cheng, F. Schwede, H.-G. Genieser, F. W. Herberg, and G. G. Holz, “Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag,” Molecular Endocrinology -Baltimore-, vol. 27, pp. 1267–1282, 2013.

http://dx.doi.org/10.1210/me.2013-1029
R. Lorenz, E. Moon, G. Huang, A. Reger, J. Kim, E. Franz, D. Bertinetti, C. Kim, and F. W. Herberg, Transforming PKA into PKG - a structure-function approach to understand cyclic nucleotide selectivity. 2013, p. TBD.

http://dx.doi.org/10.1186/2050-6511-14-S1-P41
X. Du, C. Barisch, P. Paschke, C. Herrfurth, O. Bertinetti, N. Pawolleck, H. Otto, H. Rühling, I. Feussner, F. W. Herberg, and M. Maniak, “Dictyostelium Lipid Droplets Host Novel Proteins,” Eukaryotic Cell, vol. 12, pp. 1517–1529, 2013.

http://dx.doi.org/10.1128/EC.00182-13
G. Huang, J. Kim, A. Reger, R. Lorenz, E. Moon, C. Zhao, D. E. Casteel, D. Bertinetti, B. van Schouwen, R. Selvaratnam, J. W. Pflugrath, B. Sankaran, G. Melacini, F. W. Herberg, and C. Kim, Structures of human PKG reveal cGMP-selectived activation mechanisms. 2013, p. TBD.

http://dx.doi.org/10.1186/2050-6511-14-S1-O16

2012

K. Kämpf, S. Kübler, F. W. Herberg, and A. Ehresmann, “Magneto-optic surface plasmon resonance optimum layers: Simulations for biological relevant refractive index changes,” Journal of Applied Physics, vol. 112, p. 034505, 2012.

http://dx.doi.org/10.1063/1.4742130
K. Soberg, A. C. Larsen, M. Diskar, P. H. Backe, M. Bjoras, T. Jahnsen, J. K. Laerdahl, T. Rognes, F. W. Herberg, and B. S. Skalhegg, “Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA),” PLOS ONE, vol. 7, no. 4, p. e34838, 2012.

http://dx.doi.org/10.1371/journal.pone.0034838
P. Parizek, L. Kummer, P. Rube, A. Prinz, F. W. Herberg, and A. Plückthun, “Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases,” ACS Chemical Biology, vol. 7(8), pp. 1356–1366, 2012.

http://dx.doi.org/10.1021/cb3001167
J. Duevel, D. Bertinetti, S. Müller, F. Schwede, M. Morr, J. Wissing, L. Radamm, B. Zimmermann, H.-G. Genieser, L. Jänsch, F. W. Herberg, and S. Haussler, “A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa,” Journal of Microbiological Methods, vol. 88, pp. 229–236, 2012.

http://dx.doi.org/10.1016/j.mimet.2011.11.015
L. Kummer, P. Parizek, P. Rube, B. Millgramm, A. Prinz, P. R. Mittl, M. Kaufholz, B. Zimmermann, F. W. Herberg, and A. Plückthun, “Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries,” Proceedings of the National Academy of Sciences, vol. 109(34), pp. E2248–57, 2012.

http://dx.doi.org/10.1073/pnas.1205399109

2011

O. Bertinetti, K. Singer, D. Bertinetti, S. E. Hanke, B. Boerjan, K. H. Reuner, and F. W. Herberg, “Enrichment of Amyloid-beta-peptides from cerebrospinal fluid using single solid phase extraction beads and subsequent mass spectrometry analysis,” CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol. 49, pp. S772–S772, 2011.
A. Ruppelt, R. Mosenden, M. Grönholm, E. M. Aandahl, D. Tobin, C. R. Carlson, H. Abrahamsen, F. W. Herberg, O. Carpén, and K. Taskén, “Correction: Inhibition of T Cell Activation by Cyclic Adenosine 5′-Monophosphate Requires Lipid Raft Targeting of Protein Kinase A Type I by the A-Kinase Anchoring Protein Ezrin,” The Journal of Immunology, vol. 186, no. 12, pp. 7269–7271, 2011.

http://dx.doi.org/10.4049/jimmunol.1190024
F. Gesellchen, P. Lewczuk, K. Guske, B. Zimmermann, D. Bertinetti, J. Wiltfang, K. H. Reuner, and F. W. Herberg, “Development of a new method for detection of Amyloid-beta-Peptides in cerebrospinal fluid of alzheimer patients,” Clinical Chemistry and Laboratory Medicine, vol. 49, pp. S772–S772, 2011.
J. Schmidt, M. Muesken, T. Becker, Z. Magnowska, D. Bertinetti, S. Moeller, B. Zimmermann, F. W. Herberg, L. Jaensch, and S. Haeussler, “The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling,” PLOS ONE, vol. 6, p. e18184, 2011.

http://dx.doi.org/10.1371/journal.pone.0018184
M. Lolicato, M. Nardini, S. Gazzarrini, S. Möller, D. Bertinetti, F. W. Herberg, M. Bolognesi, H. Martin, M. Fasolini, J. A. Bertrand, C. Arrigoni, G. Thiel, and A. Moroni, “Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels,” Journal of Biological Chemistry, vol. 286, pp. 44811–44820, 2011.

http://dx.doi.org/10.1074/jbc.M111.297606
U. Neubauer, D. Bertinetti, A. Prinz, and F. W. Herberg, “Proteine bei der Arbeit beobachten.” pp. 14–15, 2011.
F. Christian, M. Szaszák, S. Friedl, S. Drewianka, D. Lorenz, A. Goncalves, J. Furkert, C. Vargas, P. Schmieder, F. Götz, K. Zühlke, M. Moutty, H. Göttert, M. Joshi, B. Reif, H. Haase, I. Morano, S. Grossmann, A. Klukovits, J. Verli, R. Gáspár, C. Noack, M. Bergmann, R. Kass, K. Hampel, D. Kashin, H.-G. Genieser, F. W. Herberg, D. Willoughby, D. M. Cooper, G. S. Baillie, M. D. Houslay, J. P. von Kries, B. Zimmermann, W. Rosenthal, and E. Klussmann, “Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes,” Journal of Biological Chemistry, vol. 286, pp. 9079–9096, 2011.

http://dx.doi.org/10.1074/jbc.M110.160614
H. Murdoch, S. Vadrevu, A. Prinz, A. J. Dunlop, E. Klussmann, G. B. Bolger, J. C. Norman, M. D. Houslay, F. W. Herberg, and A. Prinz, “Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function,” Journal of Cell Science, vol. 124, no. Pt 13, pp. 2253–2266, 2011.

http://dx.doi.org/10.1242/jcs.082982
M. M. Vetter, H.-M. Zenn, E. Méndez, H. v. d. Boom, F. W. Herberg, and B. S. Skalhegg, “The testis-specific Ca2 subunit of PKA is kinetically indistinguishable from the common Ca1 subunit of PKA,” BMC Biochemistry, vol. 12, p. 40, 2011.

http://dx.doi.org/10.1186/1471-2091-12-40
S. Hanke, D. Bertinetti, A. Badel, S. Schweinsberg, H.-G. Genieser, and F. W. Herberg, “Cyclic nucleotides as affinity tools: Phosphorothioate cAMP analogues address specific PKA subproteomes,” New Biotechnology, vol. 28, pp. 294–301, 2011.

http://dx.doi.org/10.1016/j.nbt.2010.12.001
O. Stoevesandt, M. Vetter, M. M. Vetter, D. Kastelic, E. A. Palmer, M. J. Taussig, F. W. Herberg, O., Vetter, M , Kastelic, D , Palmer, E A , He, M , Taussig, M J Stoevesandt, M. Vetter, M. Vetter, and M. M. Vetter, “Cell free expression put on the spot: advances in repeatable protein arraying from DNA (DAPA),” New Biotechnology, vol. 28, no. 3, pp. 282–290, 2011.

http://dx.doi.org/10.1016/j.nbt.2010.09.004

2010

C. Hundsrucker, P. Skroblin, F. Christian, H.-M. Zenn, V. Popara, M. Joshi, J. Eichhorst, B. Wiesner, F. W. Herberg, B. Reif, W. Rosenthal, and E. Klussmann, “Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein,” Journal of Biological Chemistry, vol. 285, pp. 5507–5521, 2010.

http://dx.doi.org/10.1074/jbc.M109.047944
C. Seitz, X. Du, N. Pawolleck, K. von Löhneysen, O. Bertinetti, F. W. Herberg, and M. Maniak, “Functional analysis of the lipid droplet proteome of Dictyostelium discoideum,” in 33rd Annual Meeting of the German Society for Cell Biology (DGZ): Joint Meeting with the German Melanoma Research Network, G. M. R. N. Deutsche Gesellschaft für Zellbiologie, Ed. OFFICE JENA and P O BOX 100537 and 07705 JENA and GERMANY: ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2010, pp. 34–35.
D. E. Gloriam, S. Orchard, D. Bertinetti, E. Björling, E. Bongcam-Rudloff, C. Borrebaeck, J. Bourbeillon, A. R. Bradbury, A. de Daruvar, S. Dübel, R. Frank, T. J. Gibson, L. Gold, N. Haslam, F. W. Herberg, T. Hiltke, J. Hoheisel, S. Kerrien, M. Koegl, Z. Konthur, B. Korn, U. Landegren, L. Montecchi-Palazzi, S. Palcy, H. Rodriguez, S. Schweinsberg, V. Sievert, O. Stoevesandt, M. Taussig, M. Ueffing, M. Uhlen, S. van der Maarel, C. Wingren, P. Woollard, D. Sherman, and H. Hermjakob, “A Community Standard Format for the Representation of Protein Affinity Reagents,” Molecular and Cellular Proteomics, vol. 9, pp. 1–10, 2010.

http://dx.doi.org/10.1074/mcp.M900185-MCP200
H.-M. Zenn, S. Hutschenreiter, and F. W. Herberg, “Anti-Histidine Antibodies as Tools for Reversible Capturing of His-Tagged Fusion Proteins for Subsequent Binding Analysis,” in Antibody Engineering, D. S. Kontermann R, Ed. Berlin Heidelberg: Springer Berlin Heidelberg, 2010, pp. 667–681.

http://dx.doi.org/10.1007/978-3-642-01144-3_42
A. Badel, S. E. Hanke, and F. W. Herberg, “PKA, an All-rounder in Signal Transduction,” G.I.T Laboratory Journal, pp. 11–13, 2010.
M. Diskar, H.-M. Zenn, A. Kaupisch, M. Kaufholz, S. Brockmeyer, D. Sohmen, M. Berrera, M. Zaccolo, M. Boshart, F. W. Herberg, and A. Prinz, “Regulation of cAMP-dependent protein kinases: the human Protein Kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop,” Journal of Biological Chemistry, vol. 285, pp. 35910–35918, 2010.

http://dx.doi.org/10.1074/jbc.M110.155150
A. Erlbruch, C. W. Hung, J. Seidler, K. Borrmann, F. Gesellchen, N. König, D. Kübler, F. W. Herberg, W. D. Lehmann, and D. Bossemeyer, “Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit,” Proteomics, vol. 10, pp. 2890–2900, 2010.

http://dx.doi.org/10.1002/pmic.200900593

2009

C. Franz, F. Gesellchen, O. Bertinetti, F. W. Herberg, and F. Schmidt, “The High Biofilm-Encoding Bee Locus: A Second Pilus Gene Cluster in Enterococcus faecalis?,” Current Microbiology, vol. 59, pp. 206–211, 2009.
H. Follmann, C. Brownson, and F. W. Herberg, “Darwin’s warm little pond revisited: from molecules to the origin of life,” Naturwissenschaften, vol. 96, no. 11, pp. 1265–1292, 2009.
P. Skroblin, C. Hundsrucker, F. Christian, H.-M. Zenn, F. W. Herberg, W. Rosenthal, and E. Klussmann, Identification of GSKIP as an AKAP, vol. 379. 2009, pp. 28–28.
A. Prinz, F. W. Herberg, and U. N. M. Pages, “PrKX,” USCD Nature Molecule Pages, p. TBD, 2009.

http://dx.doi.org/10.1038/mp.a002999.01
B. C. Viertlboeck, S. Schweinsberg, R. Schmitt, F. W. Herberg, and T. W. Göbel, “The Chicken Leukocyte Receptor Complex Encodes a Family of Different Affinity FcY Receptors,” Journal of Immunology, vol. 182, pp. 6985–6992, 2009.
D. Bertinetti and F. W. Herberg, “Biochemie: Das Bindungsverhalten von Proteinen - und was man damit anfangen kann.” p. 8, 2009.
D. Bertinetti, S. Schweinsberg, S. Hanke, F. Schwede, O. Bertinetti, S. Drewianka, H.-G. Genieser, and F. W. Herberg, “Chemical tools selectively target components of the PKA system,” BMC Chemical Biology, vol. 9, p. 3, 2009.
K. A. Wojtal, M. Diskar, F. W. Herberg, D. Hoekstra, and S. C. van Ijzendoorn, “Regulatory Subunit I-controlled Protein Kinase A Activity Is Required for Apical Bile Canalicular Lumen Development in Hepatocytes,” Journal of Biological Chemistry, vol. 284, pp. 20773–20780, 2009.

2008

B. Zimmermann, S. Schweinsberg, S. Drewianka, and F. W. Herberg, “Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA,” Biochemical Journal, vol. 413, pp. 93–101, 2008.
M. J. Farquhar, H. J. Harris, M. Diskar, S. Jones, C. J. Mee, S. U. Nielsen, C. L. Brimacombe, S. Molina, G. L. Toms, P. Maurel, J. Howl, F. W. Herberg, S. C. van Ijzendoorn, P. Balfe, and J. A. McKeating, “Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity,” Journal of Virology, vol. 82, no. 17, pp. 8797–8811, 2008.

http://dx.doi.org/10.1128/JVI.00592-08
D. M. Collins, H. Murdoch, A. J. Dunlop, E. Charych, G. Baillie, Q. Wang, F. W. Herberg, N. Brandon, A. Prinz, and M. D. Houslay, “Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA),” in Cellular Signalling, vol. 20, 2008, pp. 2356–2369.
S. Schweinsberg, D. Moll, N. Burghardt, C. Hahnefeld, F. Schwede, B. Zimmermann, S. Drewianka, L. Werner, F. Kleinjung, H.-G. Genieser, J. Schuchhardt, and F. W. Herberg, “Systematic interpretation of cyclic nucleotide binding studies using KinetXBase,” Proteomics, vol. 8, pp. 1212–1220, 2008.

http://dx.doi.org/10.1002/pmic.200700731
D. Moll, A. Prinz, C. M. Brendel, M. Berrera, K. Guske, M. Zaccolo, H.-G. Genieser, and F. W. Herberg, “Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog,” BMC Biochemistry, vol. 9, p. 18, 2008.

http://dx.doi.org/10.1186/1471-2091-9-18
S. E. Roth, O. Bertinetti, and F. W. Herberg, “Die Masse macht’s! - Massenspektrometrie als interdisziplinäres Werkzeug,” BIOforum, p. TBD, 2008.
M. Hamacher, F. W. Herberg, M. Ueffing, and H. E. Meyer, “Seven successful years of Omics research: The Human Brain Proteome Project within the National German Research Network (NGFN),” Proteomics, vol. 8, pp. 1116–1117, 2008.

http://dx.doi.org/10.1002/pmic.200890017
M. Szaszák, F. Christian, D. Lorenz, J. Furkert, H. Immig, K. Hampel, B. Zimmermann, H.-M. Zenn, F. W. Herberg, J. P. von Kries, W. Rosenthal, and E. Klussmann, Inhibition of the interactions between protein kinase A and A kinase anchoring proteins in cardiac myocytes, vol. 377. 2008, pp. 52–53.

2007

F. W. Herberg and D. Moll, “Molekulare Mechanismen der cAMP-vermittelten Signaltransduktion,” 2007.
A. Ruppelt, R. Mosenden, E. M. Grönholm, E. Aandahl, D. Tobin, C. Carlson, H. Abrahamsen, F. W. Herberg, O. Carpén, K. Taskén, and A. R. Ruppelt, “Inhibition of T cell activation by cyclic adenosine 5’-monophosphate requires lipid raft targeting of protein kinase a type I by the a-kinase anchoring protein Ezrin,” Journal of Immunology, vol. 179, pp. 5159–5168, 2007.
M. Taussig, O. Stoevesandt, C. Borrebaeck, A. R. Bradbury, D. Cahill, C. Cambillau, A. de Daruvar, S. Dübel, J. Eichler, R. Frank, T. Gibson, D. E. Gloriam, L. Gold, F. W. Herberg, H. Hermjakob, J. Hoheisel, T. Joos, O. Kallioniemi, M. Koegl, Z. Konthur, B. Korn, E. Kremmer, S. Krobitsch, U. Landegren, S. van der Maarel, J. McCafferty, S. Muyldermans, P. A. Nygren, S. Palcy, A. Plückthun, B. Polic, M. Przybylski, P. Saviranta, A. Sawyer, D. Sherman, A. Skerra, M. Templin, M. Ueffing, and M. Uhlen, “ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome,” Nature Methods, pp. 13–17, 2007.
D. Moll, S. Schweinsberg, C. Hammann, and F. W. Herberg, “Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A,” Biological Chemistry, vol. 388, pp. 163–172, 2007.
M. Diskar, H.-M. Zenn, A. Kaupisch, and F. W. Herberg, “Molecular basis for isoform-specific autoregulation of protein kinase A - insights from the human catalytic subunit PrKX,” Cellular Signalling, vol. 19, pp. 2024–2034, 2007.
N. Mirow, B. Zimmermann, A. Maleszka, H. Knobel, G. Tenderich, R. Koerfer, and F. W. Herberg, “Plasma protein properties to immobilized heparin and heparin-albumin-conjugate,” Artificial Organs, vol. 31, pp. 466–471, 2007.
K. Viht, S. Schweinsberg, M. Lust, A. Vaasa, G. Raidaru, D. Lavogina, A. Uri, and F. W. Herberg, “Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase,” Analytical Biochemistry, vol. 362, pp. 268–277, 2007.
M. Hamacher, C. Stefan, M. Eisenacher, A. van Hall, K. Markus, L. Martens, Y. M. Park, H. B. Gutstein, F. W. Herberg, and H. E. Meyer, “Proteomics for everyday use: Activities of the HUPO Brain Proteome Project during the 5(th) HUPO World Congress,” vol. 7, pp. 1012–1015, 2007.
B. C. Viertlböck, S. Schweinsberg, M. A. Hanczaruk, R. Schmitt, F. W. Herberg, and T. W. Göbel, “The chicken leukocyte receptor complex encodes a primordial, activating, high affinity IgY Fc receptor,” Proceedings of the National Academy of Sciences, vol. 104, pp. 11718–23, 2007.

2006

D. Bertinetti, A. Prinz, F. Gesellchen, F. W. Herberg, B. Zimmermann, and S. Drewianka, “Biomolecular interaction analysis in functional proteomics,” Journal of Neural Transmission, vol. 113, pp. 1015–1032, 2006.

http://dx.doi.org/10.1007/s00702-006-0515-5
D. Moll, S. Schweinsberg, S. Drewianka, and F. W. Herberg, “Biomolekulare Interaktionsanalyse - Ein Werkzeug der funktionellen Proteomforschung?,” BIOforum, p. TBD, 2006.
M. Hamacher, R. Apweiler, G. K. Arnold, A. Becker, M. Bluggel, O. Carrette, C. Colvis, M. J. Dunn, T. Frohlich, M. Fountoulakis, A. van Hall, F. W. Herberg, J. Ji, H. A. Kretzschmar, P. Lewczuk, G. Lubec, K. Markus, L. Martens, N. Palacios Bustamante, Y. M. Park, S. R. Pennington, J. Robben, K. Stuhler, K. Reidegeld, P. Riederer, J. Rossier, J. C. Sanchez, M. Schrader, C. Stefan, D. Tagle, H. Thiele, J. Wang, J. Wiltfang, J. S. Yoo, X. Zhang, J. Klose, and H. E. Meyer, “HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy,” Proteomics, vol. 6, no. 18, pp. 4890–4898, 2006.

http://dx.doi.org/10.1002/pmic.200600295
A. Prinz, M. Diskar, and F. W. Herberg, “Application of Bioluminescence Resonance Energy Transfer (BRET) for biomolecular interaction studies,” vol. 7, pp. 1007–1012, 2006.
H. Seitz, S. Hutschenreiter, C. Hultschig, C. Zeilinger, B. Zimmermann, F. Kleinjung, J. Schuchhardt, H. Eickhoff, and F. W. Herberg, “Differential binding studies applying functional protein microarrays and surface plasmon resonance,” Proteomics, vol. 6, pp. 5132–5139, 2006.
F. Gesellchen, O. Bertinetti, and F. W. Herberg, “Analysis of posttranslational modifications exemplified using protein kinase A,” BBA - Proteins and Proteomics, vol. 1764, pp. 1788–1800, 2006.
A. Terrin, G. Di Benedetto, V. Pertegato, Y. F. Cheung, G. Baillie, M. J. Lynch, N. Elvassore, A. Prinz, F. W. Herberg, M. D. Houslay, and M. Zaccolo, “PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases,” Journal of Cell Biology, vol. 175, pp. 441–451, 2006.
A. J. Stokka, F. Gesellchen, C. R. Carlson, J. D. Scott, F. W. Herberg, and K. Taskén, “Characterization of A-kinase-anchoring disruptors using a solution based assay,” Biochemical Journal, vol. 400, pp. 493–499, 2006.
F. Gesellchen, A. Prinz, B. Zimmermann, and F. W. Herberg, “Quantification of cAMP antagonist action in vitro and in living cells,” European Journal of Cell Biology, vol. 85, pp. 663–672, 2006.
M. Diskar, F. W. Herberg, and A. Prinz, “Quantifizierung intrazellulärer Protein-Protein-Wechselwirkungen,” BIOspektrum, p. TBD, 2006.
A. Prinz, M. Diskar, A. Erlbruch, and F. W. Herberg, “Novel, isotype-specific sensors for Protein Kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET),” Cellular Signalling, vol. 18, pp. 1616–1625, 2006.
C. Hundsrucker, G. Krause, M. Beyermann, A. Prinz, B. Zimmermann, O. Diekmann, D. Lorenz, E. Stefan, P. Nedvetsky, M. Dathe, F. Christian, T. McSorley, E. Krause, G. McConnachie, F. W. Herberg, J. D. Scott, W. Rosenthal, and E. Klussmann, “High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A anchoring disruptor peptides,” Biochemical Journal, vol. 396, pp. 297–306, 2006.

2005

C. Lenz, O. Bertinetti, and F. W. Herberg, “Complete Characterisation of the Phosphorylation Sites of Protein Kinase,” Applied Biosystems technical note, p. TBD, 2005.
C. Hundsrucker, M. Beyermann, A. Prinz, B. Zimmermann, F. W. Herberg, G. Krause, T. McSorley, D. Lorenz, W. Rosenthal, and E. Klussmann, Peptide disruptors of AKAP-PKA interactions, vol. 371. 2005, pp. R52–R52.
C. Hahnefeld, D. Moll, M. Goette, and F. W. Herberg, “Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA,” Biological Chemistry, vol. 386, pp. 623–631, 2005.
F. W. Herberg, F. Gesellchen, A. Prinz, and D. Moll, Biomolecular interaction analysis as a general tool for functional proteomics, vol. 4. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005, pp. S49–S49.
M. Diskar, F. W. Herberg, and A. Prinz, Investigating human protein kinase X holoenzyme formation using bioluminescence resonance energy transfer (BRET), vol. 272. 2005, pp. 303–303.
F. Gesellchen, B. Zimmermann, and F. W. Herberg, “Direct optical detection of protein-ligand interactions,” Methods in Molecular Biology, vol. 305, pp. 17–46, 2005.
A. Ramanavieius, F. W. Herberg, S. Hutschenreiter, B. Zimmermann, I. Lapenaite, A. Kausaite, A. Finkelsteinas, and A. Ramanavieiene, “Biochemical application of surface Plasmon resonance biosensors,” Acta Medica Lituanica, vol. 12, pp. 1–9, 2005.
S. Schweinsberg, D. Moll, and F. W. Herberg, Eds., Protein-ligand binding investigated by biomolecular Interaction Analysis (BIA). Berlin and Germany, 2005.
D. Moll, N. Burghardt, and F. W. Herberg, Eds., Physico-chemical tools for functional characterization of protein-cyclic nucleotide interaction. Berlin and Germany, 2005.

2004

H. Heide, H. Kalisz, H. Follmann, and F. W. Herberg, “The oxygen evolving enhancer protein 1 (OEE) of photosystem II in green algae exhibits thioredoxin activity,” Journal of Plant Physiology, vol. 161, pp. 139–149, 2004.

http://dx.doi.org/10.1078/0176-1617-01033
C. Hahnefeld, S. Drewianka, and F. W. Herberg, “Determination of Kinetic Data Using Surface Plasmon Resonance Biosensors,” Methods in Molecular Medicine, pp. 299–320, 2004.
H. Seitz, C. Hultschig, H. Eickhoff, C. Zeilinger, C. Gotthold, U. Borgmeier, and F. W. Herberg, Identification of protein-protein interactions using protein microarrays and surface plasmon resonance measurements, vol. 3. 2004, pp. S273–S273.
M. Gronholm, L. Vossebein, C. R. Carlson, T. Teesalu, K. Alfthan, A. Vaheri, H. Rauvala, F. W. Herberg, K. Tasken, J. Kuja-Panula, and O. Carpén, “Merlin links to the camp neuronal signaling pathway by anchoring the Rib subunit of protein kinase A,” Journal of Neurochemistry, vol. 88, pp. 29–29, 2004.
H. Follmann and F. W. Herberg, “Deoxyribonucleotides: the unusual chemistry and biochemistry of DNA precursors,” in Chemical Society Reviews, vol. 33, 2004, pp. 225–233.
C. Zeilinger and F. W. Herberg, “Chip Design für die Biomolekulare Interaktionsanalyse,” Telekommunikation Aktuell, p. TBD, 2004.
A. Prinz, A. Erlbruch, and F. W. Herberg, Monitoring cAMP dependent protein kinase subunit interaction in intact cells using bioluminescence resonance energy transfer (BRET), vol. 18. 2004, pp. C159–C160.
H. J. Thierse, C. Moulon, Y. Allespach, B. Zimmermann, A. Doetze, S. Kuppig, D. Wild, F. W. Herberg, and H. U. Weltzien, “Metal-Protein Complex-Mediated Transport and Delivery of Ni(2+) to TCR/MHC Contact Sites in Nickel-Specific Human T Cell Activation,” Journal of Immunology, vol. 279, pp. 1926–34, 2004.
V. Henn, B. Edemir, E. Stefan, B. Wiesner, D. Lorenz, F. Theilig, R. Schmitt, L. Vossebein, G. Tamma, M. Beyermann, E. Krause, F. W. Herberg, G. Valenti, S. Bachmann, W. Rosenthal, and E. Klussmann, “Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells,” Journal of Biological Chemistry, vol. 279, pp. 26654–26665, 2004.

2003

C. Lenz, V. Kruft, F. W. Herberg, and C. Zeilinger, “Neue Strategien zur Analyse posttranslationaler Proteinmodifikationen auf einem hybriden Triple Quadrupol -Linearen Ionenfallen Massenspektrometer,” Applied Biosystems technical note, p. TBD, 2003.
O. J. Sichelschmidt, C. Hahnefeld, T. Hohlfeld, F. W. Herberg, and K. Schror, “Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity,” Cardiovascular Research, vol. 58, pp. 602–610, 2003.
S. Yaqub, A. Abrahamsen, B. Zimmermann, N. Kholod, K. M. Torgersen, T. Mustelin, F. W. Herberg, K. Taskén, and T. Vang, “Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain,” Biochemical Journal, vol. 372, pp. 271–278, 2003.
M. Gronholm, L. Vossebein, C. R. Carlson, J. Kuja-Panula, T. Teesalu, K. Alfthan, A. Vaheri, H. Rauvala, F. W. Herberg, K. Tasken, and O. Carpén, “Merlin links to the cAMP neuronal signaling pathway by anchoring the RI Chi subunit of protein kinase A,” Journal of Biological Chemistry, vol. 278, pp. 41167–41172, 2003.
M. Gronholm, L. Vossebein, C. R. Carlson, J. Kuja-Panula, T. Teesalu, K. Alfthan, A. Vaheri, H. Rauvala, F. W. Herberg, K. Taskén, and O. Carpén, “Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A,” Journal of Biological Chemistry, vol. 278, pp. 41167–72, 2003.
K. Marcus, C. Hultschig, R. Frank, F. W. Herberg, J. Schuchhardt, and H. Seitz, “Innovative Forschungsansätze im NGFN Verbund "The Human Brain Proteome Project HBPP,” GenomXPress, p. TBD, 2003.

2002

O. J. Sichelschmidt, C. Hahnefeld, T. Hohlfeld, F. W. Herberg, and K. Schror, “A triazolopyrimidine reduces myocardial ischemic reperfusion injury by stimulating PKAII-dependent phosphorylation of phospholamban,” 2002, p. TBD.
B. Zimmermann, C. Hahnefeld, and F. W. Herberg, “Applications of biomolecular interaction analysis in drug development,” Targets, pp. 66–73, 2002.

2001

S. Suer, A. Sickmann, H. E. Meyer, F. W. Herberg, and L. M. Heilmeyer, “Human phosphatidylinositol 4-kinase isoform PI4K92 Expression of the recombinant enzyme and determination of multiple phosphorylation sites,” European Journal of Biochemistry, vol. 268, no. 7, pp. 2099–106, 2001.
H. B. Landsverk, C. R. Carlson, R. L. Steen, L. Vossebein, F. W. Herberg, K. Taskén, and P. Collas, “Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis,” Journal of Cell Science, vol. 114, pp. 3255–64, 2001.
L. Vossebein and F. W. Herberg, “Multiplicity and Anchoring of PKA Isozymes Detected by Surface Plasmon Resonance,” in Protein Modules in Cellular Signalling, F. P. Heilmeyer L, Ed. IOS Press, 2001, pp. 50–58.
C. R. Carlson, O. Witczak, L. Vossebein, J. C. Labbe, B. S. Skalhegg, G. Keryer, F. W. Herberg, P. Collas, and K. Taskén, “CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis,” Journal of Cell Science, vol. 114, pp. 3243–3254, 2001.

2000

A. Toth, E. Kiss, F. W. Herberg, P. Gergely, D. J. Hartshorne, and D. J. Erdodi, “Study of the subunit interactions in myosin phosphatase by surface plasmon resonance,” European Journal of Biochemistry, vol. 267, pp. 1687–1697, 2000.
X. Wang, F. W. Herberg, M. M. Laue, C. Wullner, B. Hu, E. Petrasch-Parwez, and M. W. Kilimann, “Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic,” Journal of Neuroscience, vol. 20, pp. 8551–8565, 2000.
K. Jaquet, S. Deppermann, and F. W. Herberg, “Phospho-NMR-spectrocopy reveals chances in the chemical environment P-Thr197 in the catalytic subunit of cAMP-dependent protein-kinase,” 2000, p. TBD.
A. Herzog, C. Szegedi, I. Jona, F. W. Herberg, and M. Varsanyi, “Surface Plasmon Resonance studies prove the interaction of skeletal muscle sarcoplasmic reticular Ca2+ release channel/ryanodine receptor with calsequestrin,” FEBS Letters, vol. 472, pp. 73–77, 2000.
B. Zimmermann, C. Hahnefeld, and F. W. Herberg, “Divalent metals modulate the binding affinity of physiological inhibitors of protein kinase A,” 2000, p. TBD.
F. W. Herberg, A. Maleszka, T. Eide, L. Vossebein, and K. Taskén, “Analysis of A-Kinase Anchoring Protein (AKAP) Interaction with Protein Kinase A (PKA) Regulatory Subunits: PKA Isoform Specificity in AKAP Binding,” J. Mol. Biol, vol. 298, pp. 329–339, 2000.

1999

W. Schliebs, J. Saidowsky, B. Agianian, G. Dodt, F. W. Herberg, and W. Kunau, “Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14,” Journal of Biological Chemistry, vol. 274, pp. 5666–5673, 1999.

http://dx.doi.org/10.1074/jbc.274.9.5666
B. Zimmermann, M. Chiorini, Y. Ma, R. Kotin, and F. W. Herberg, “PrKX is a Novel Catalytic Subunit of the cAMP-Dependent Protein Kinase regulated by the Regulatory Subunit Type I,” Journal of Biological Chemistry, vol. 274, pp. 5370–5378, 1999.
F. W. Herberg, M. Doyle, S. Cox, and S. S. Taylor, “Dissection of the Nucleotide and Metal-Phosphate Binding Sites in cAMP-dependent Protein Kinase,” Biochemistry, vol. 38, pp. 6352–60, 1999.
T. Gehrmann, H. Gülkan, S. Suer, F. W. Herberg, A. Balla, G. Vereb, G. W. Mayr, and L. M. Heilmeyer, “Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230,” BBA - Biochimica et Biophysica Acta, vol. 1437, pp. 341–356, 1999.
W. Schliebs, J. Saidowski, B. Agianian, G. Dodt, F. W. Herberg, and W. Kunau, “Recombinant Human PTS-1-Receptor PEX5: Structural Basis for Interaction of PEX5 with PEX14,” Journal of Biological Chemistry, vol. 274, pp. 5666–5673, 1999.

1998

W. Schliebs, J. Saidowsky, B. Agianian, F. W. Herberg, G. Dodt, and W. Kunau, Structural studies on the recombinant human PTS1-receptor PEX5 and its interaction with PEX14, vol. 9. AMER SOC CELL BIOLOGY, 1998, p. 349A–349A.
M. Chiorini, B. Zimmermann, L. Yang, R. H. Smith, A. Ahearn, F. W. Herberg, and R. Kotin, “Inhibition of PrKX, a Novel Protein Kinase, and the cAMP-Dependent Protein Kinase PKA, by the Regulatory Proteins of Adeno-Associated Virus Type 2,” Molecular and Cellular Biology, vol. 18, pp. 5921–5929, 1998.
S. U. Reiffert, K. Jaquet, L. M. Heilmeyer, and F. W. Herberg, “Stepwise Subunit Interaction Changes by Mono and Bisphosphorylation of Cardiac Troponin I,” Biochemistry, vol. 37, no. 39, pp. 13516–13525, 1998.
B. Zimmermann and F. W. Herberg, “Interactions of 6xHis-tagged protein kinase A catalytic subunit examined using Ni-NTA Magnetic Agarose Beads,” Qiagen News, p. TBD, 1998.

1997

A. Maleszka and F. W. Herberg, “Interaction Studies using Biosensors,” in Interacting Protein Domains: Their Role in Signal and Energy Transdution, L. Heilmeyer, Ed. Springer, 1997, pp. 27–36.
F. W. Herberg and M. D. Stefano, “High Speed Separation of Isozymes of Recombinant cAMP Dependent Protein Kinase Using UNOTM S1 and S6 Columns,” BIORAD technical note, p. TBD, 1997.
F. W. Herberg, D. León, P. Banky, and S. S. Taylor, “A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif,” Journal of Biological Chemistry, vol. 272, pp. 28431–28437, 1997.
F. W. Herberg, B. Zimmermann, M. M. McGlone, and S. S. Taylor, “Importance of the A-helix of the catalytic subunitof the cAMP-dependent Protein kinase for stability and for orienting subdomains at the cleft interface,” Protein Science, vol. 6, pp. 569–579, 1997.
B. Zimmermann, A. Klink, G. Rappolt, and F. W. Herberg, “Protein Kinase X: A Novel Human Protein Kinase related to the Catalytic Subunit of cAMP-dependent Protein Kinase,” in Interacting Protein Domains: Their Role in Signal and Energy Transdution, L. Heilmeyer, Ed. Springer, 1997, pp. 15–18.
F. W. Herberg, S. U. Reiffert, K. Jaquet, and L. M. Heilmeyer, “Studies on the Function of Different Phosphoforms of Cardiac Troponin I,” in Interacting Protein Domains: Their Role in Signal and Energy Transdution, L. Heilmeyer, Ed. nn: Springer, 1997, pp. 281–288.
W. Jäger, B. Haase, V. Lutz, F. W. Herberg, and B. Zimmermann, “Biomolekulare Interaktionsanalyse (BIA) mit SPR-Biosensortechnologie,” BIOspektrum, p. TBD, 1997.

1996

F. W. Herberg, S. S. Taylor, and W. R. G. Dostmann, “Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase,” Biochemistry, vol. 35, pp. 2934–42, 1996.

1995

Y. Su, W. R. G. Dostmann, F. W. Herberg, K. Durick, N.-H. Xuong, S. S. Taylor, and K. I. Varughese, “Regulatory Subunit of Protein Kinase A: Structure of a Deletion Mutant with cAMP Binding Domains,” Science, vol. 269, pp. 807–813, 1995.
N. Wild, F. W. Herberg, F. Hofmann, and W. R. G. Dostmann, “Expression of a chimeric, cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I alpha,” vol. 374, no. 3, pp. 356–362, 1995.

1994

F. W. Herberg, W. R. G. Dostmann, M. Zorn, S. J. Davis, and S. S. Taylor, “Crosstalk between Domains in the Regulatory Subunit of cAMP-dependent Protein Kinase: Influence of the Amino-Terminus of cAMP-binding and Holoenzyme Formation,” Biochemistry, vol. 33, no. 23, pp. 7485–7494, 1994.

1993

F. W. Herberg, W. M. Yonemoto, and S. S. Taylor, “AUTOPHOSPHORYLATION SITES ON THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE,” 1993, p. 269.
Y. J. Buechler, F. W. Herberg, and S. S. Taylor, “Regulation defective mutants of type I cAMP-dependent protein kinase. Consequences of replacing arginine 94 and arginine 95,” Journal of Biological Chemistry, vol. 268, pp. 16495–16503, 1993.
F. W. Herberg, W. M. Yonemoto, and S. S. Taylor, “The Catalytic Subunit of cAMP-dependent Protein Kinase,” in Tyrosine Phosphorylation/ Dephosphorylation and Downstream Signalling, Heilmeyer LMG, Ed. Springer, 1993, pp. 203–213.
W. Wen, F. W. Herberg, and S. S. Taylor, “MUTANTS OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE THAT ARE DEFECTIVE IN RECOGNITION OF THE HEAT-STABLE PROTEIN-KINASE INHIBITOR,” 1993, p. A1122.
S. S. Taylor, E. Radzio-Andzelm, D. R. Knighton, L. T. Eyck, J. M. Sowadski, F. W. Herberg, W. M. Yonemoto, and J. Zheng, “Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family,” Receptor, vol. 3, pp. 165–172, 1993.
F. W. Herberg, W. R. G. Dostmann, and S. S. Taylor, “BIOCHEMICAL-PROPERTIES OF A MONOMERIC REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE,” 1993, p. A1122.
F. W. Herberg and S. S. Taylor, “Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions,” Biochemistry, vol. 32, pp. 14015–14022, 1993.

http://dx.doi.org/10.1021/bi00213a035
S. S. Taylor, J. Zheng, E. Radzio-Andzelm, D. R. Knighton, L. T. Eyck, J. M. Sowadski, F. W. Herberg, and W. M. Yonemoto, “cAMP-dependent protein kinase defines a family of enzymes,” Philos Trans R Soc Lond B Biol Sci, vol. 340, pp. 315–324, 1993.

http://dx.doi.org/10.1098/rstb.1993.0073
F. W. Herberg, S. M. Bell, and S. S. Taylor, “Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase in E. coli: Multiple Isozymes Reflect Different Phosphorylation States,” Prot. Eng., vol. 6, no. 7, pp. 771–777, 1993.

1992

R. Benterbusch, F. W. Herberg, W. Melzer, and R. Thieleczeck, “Excitation-Contracting Coupling in a Pre-Vertebrate Twitch Muscle: The Myotomes of Branchiostoma lanceolatum,” J. Membrane Biol, vol. 129, pp. 237–252, 1992.

1991

S. S. Taylor, W. M. Yonomoto, W. R. G. Dostmann, D. R. Knighton, J. M. Sowadski, F. W. Herberg, and Y. Ji-Buechler, “Protein kinase Structure and Function: cAMP-dependent Protein Kinase,” in Cellular Regulation by Protein Phosphorylation, Heilmeyer LMG, Ed. Springer, 1991, pp. 91–105.
F. W. Herberg and S. S. Taylor, “Conformational and Shape Changes associated with cAMP-dependent Protein Kinase,” in Cellular Regulation by Protein Phosphorylation, Heilmeyer LMG, Ed. Berlin Heidelberg: Springer, 1991, pp. 119–123.

1989

F. W. Herberg, R. Thieleczek, and L. M. Heilmeyer, “Biochemical-Characterization of myotome muscle membranes of bronchiostoma-lanceolatum,” Journal of Muscle Research and Cell Motility, vol. 10, p. 176, 1989.

1988

F. W. Herberg, R. Thieleczek, and L. M. Heilmeyer, “Preparation and characterization of Myotome Membrane vesicles of branchiostoma Lanceolatum,” in Sarcomeric and Non-Sarcomeric Muscles: Basic applied research Prospects for the 90’s, U. Carraro, Ed. Unipress Padova, 1988, pp. 619–624.

Peer reviewed research articles

  1. Merker D, Kesper M, Kailing LL, Herberg FW, Reithmaier JP, Pavlidis IV, Popov C. Nanostructured modified ultrananocrystalline diamond surfaces as immobilization support for lipases. Diamond & Related Materials. 90 (2018) 32–39
  2. Espiard S, Knape MJ, Bathon K, Assié G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J. Activating PRKACB somatic mutation in cortisol-producing adenomas. JCI Insight. 2018 Apr 19;3(8). pii: 98296. doi: 10.1172/jci.insight.98296.
  3. Kailing LL, Bertinetti D, Paul CE, Manszewski T, Jaskolski M, Herberg FW, Pavlidis IV. S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic. Front Microbiol. 2018 Mar 21;9:505. doi: 10.3389/fmicb.2018.00505. eCollection 2018.
  4. Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T. PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination. J Cell Biol. 2018 Jun 4;217(6):2167-2184.doi: 10.1083/jcb.201708053
  5. Bendzunas NG, Dörfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg Med Chem. 2018 Feb 12. pii: S0968-0896(17)31514-6. doi: 10.1016/j.bmc.2018.02.001. [Epub ahead of print]
  6. Vighi E, Rentsch A, Henning P, Comitato A, Hoffmann D, Bertinetti D, Bertolotti E, Schwede F, Herberg FW, Genieser HG, Marigo V. New cGMP analogues restrain proliferation and migration of melanoma cells Oncotarget. 2017 Dec 25;9(4):5301-5320. doi: 10.18632/oncotarget.23685. eCollection 2018 Jan 12.PMID:29435180
  7. Franz E, Knape MJ, Herberg FW. cGMP binding domain D mediates a unique activation mechanism in Plasmodium falciparum PKG. ACS Infect Dis. 2018 Mar 9;4(3):415-423. doi: 10.1021/acsinfecdis.7b00222. Epub 2017 Dec 26.
  8. He D, Lorenz R, Kim C, Herberg FW, Lim CJ.  Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains. ACS Chem Biol. 2017 Nov 21. doi: 10.1021/acschembio.7b00732.
  9. Knape MJ, Ballez M, Burghardt NC, Zimmermann B, Bertinetti D, Kornev AP and Herberg FW Divalent metal ions control activity and inhibition of protein kinases Metallomics 2017 2017 Nov 15;9(11):1576-1584
  10. Pérez-Mendoza D, Bertinetti D, Lorenz R, Gallegos MT, Herberg FW, Sanjuán J. A novel c-di-GMP binding domain in glycosyltransferase BgsA is responsible for the synthesis of a mixed-linkage β-glucan. Sci Rep. 2017 Aug 21;7(1):8997. doi: 10.1038/s41598-017-09290-2.
  11.  Campbell JC, Henning P, Franz E, Sankaran B, Herberg FW, Kim C. Structural Basis of Analog Specificity in PKG I and II.ACS Chem Biol. 2017 Aug 9. doi: 10.1021/acschembio.7b00369.
  12. Kailing LL, Bertinetti D, Herberg FW, Pavlidis IV A coupled photometric assay for characterization of S-adenosyl-L-homocysteine hydrolases in the physiological hydrolytic direction. N Biotechnol. 2017 Apr 28. pii: S1871-6784(17)30111-5. doi: 10.1016/j.nbt.2017.04.005.
  13. Lorenz R, Moon, EW, Kim, JJ, Schmidt, SH, Sankaran, S, Pavlidis, IV, Kim, C, Herberg, FW, Mutations of PKA cyclic nucleotide binding domains reveal novel aspects of cyclic nucleotide selectivity Biochem J. 2017 Jul 6;474(14):2389-2403. doi: 10.1042/BCJ20160969
  14. Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg FW, Schwede F, Stein C, Jordt SE, Brackmann M, Spahn V.Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. Eur J Pain. 2017 Feb 9. doi: 10.1002/ejp.1008.
  15. Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of PKG Iβ CNB-B:Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan;591(1):221-230. doi: 10.1002/1873-3468.12505. Epub 2016 Dec 23.
  16. Jamsari J, Ferita I, Noverta A, Dharma Husada E, Herberg FW, Nellen W and Syukriani L: A Pathogenic Isolate of Monopartite PepYLCV DNA A-like Genome Differs Significantly in C1 Gene and CR Sequence, but not in their other Genes Plant Pathol. J., 15 (4): 124-134, 2016
  17. Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18: PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA Biochem J. 2016 Apr 21. pii: BCJ20160242.
  18. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation Structure. 2016 Apr 5. pii: S0969-2126(16)00087-3. doi: 10.1016/j.str.2016.03.009. PMID: 27066748
  19. Kibat J, Schirrmann T, Knape MJ, Helmsing S, Meier D, Hust M, Schröder C, Bertinetti D, Winter G, Pardes K, Funk M, Vala A, Giese N, Herberg FW, Dübel S, Hoheisel JD. Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality. N Biotechnol. 2016 Sep 25;33(5 Pt A):574-81. doi: 10.1016/j.nbt.2015.12.003.
  20. Autenrieth K, Bendzunas G, Bertinetti D, *Herberg FW, *Kennedy EJ.  Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI). Chembiochem. 2016 Apr 15;17(8):693-7. doi: 10.1002/cbic.201500632
  21. VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG). J Biol Chem. 2015 290(48):28631-41 doi: 10.1074/jbc.M115.685305.
  22. Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch L, Herberg FW, Frank R, Häussler S. Application of synthetic peptide arrays to uncover c-di-GMP binding motifs. J Bacteriol. 2015 Aug 31. pii: JB.00377-15.
  23. Knape, MJ, Ahuja, LG, Bertinetti, D, Burghardt, NCG, Zimmermann, B, Taylor, SS, Herberg, FW Divalent metal ions Mg2+ and Ca2+ have distinct effects on protein kinase A activity and regulation ACS Chem Biol. 2015 Oct 16;10(10):2303-15. doi: 10.1021/acschembio.5b00271. Epub 2015 Aug 5.
  24. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, *Herberg FW, *Taylor SS. (2015) Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. PLoS Biol 13(7): e1002192. doi:10.1371/journal.pbio.1002192
  25. Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose- Stimulated Insulin Sekcretion .Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330
  26. Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW. “Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein” Biochim Biophys Acta. 2015 Apr 23. pii: S1570-9639(15)00115-6. doi: 10.1016/j.bbapap.2015.04.018.
  27. anoharan GB1, Enkvist E1, Kasari M1, Viht K1, Zenn M2, Prinz A2, Filhol O3, Herberg FW2, Uri A4.FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases  Analytical Biochemistry 2015 Apr 9. pii: S0003-2697(15)00155-4. doi: 10.1016/j.ab.2015.04.009.
  28. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Apr 3. pii: S1570-9639(15)00093-X. doi: 10.1016/j.bbapap.2015.03.012.
  29. Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ. “PKA-type I Selective Constrained Peptide Disruptors of AKAP Complexes” ACS Chem Biol. 2015 Jun 19;10(6):1502-10. doi: 10.1021/acschembio.5b00009. Epub 2015 Mar 25.
  30. Jamsari, Lily Syukriani, Hashlin Pascananda Utami, Friedrich Herberg, Wolfgang Nellen and Istino Ferita Injection Technique Could as a New Promising Method for Artificial Infection of Geminivirus Particles in Chili Pepper (Capsicum annuum L.) Asian J of Agriculture 9 (1) 23-32,  2015
  31. Kim JJ, Flueck C, Franz E, Sanabria-Figueroa E, Thompson E, Lorenz R, Bertinetti D, Baker DA, Herberg FW, Kim C. Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.PLoS Pathog. 2015 Feb 3;11(2):e1004639. doi: 10.1371/journal.ppat.1004639. eCollection.
  32. Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H. Structure-guided design of selective Epac1 and Epac2 agonists PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.
  33. Jamsari Jamsari, Istino Ferita, Lily Syukriani, Helni Lalan, Friedrich Herberg and Wolfgang Nellen The Existence of Two Distinct Whiteflies in Chilli-Pepper Cultivation in West Sumatra-Indonesia Based on Mitochondria Cytochrome Oxidase I Gene Sequences Asian Journal for Plant Pathology 2014
  34. Möller S, Alfieri A, Bertinetti D, Aquila M, Schwede F, Lolicato M, Rehmann H, Moroni A, Herberg FW. Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels ACS Chem Biol. 2014 May 16;9(5):1128-37. doi: 10.1021/cb400904s. Epub 2014 Mar 7.
  35. Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-Specific Disruption of AKAP-localized PKA Using Hydrocarbon Stapled Peptides ACS Chem Biol. 2014 Mar 21;9(3):635-42. doi: 10.1021/cb400900r. Epub 2014 Jan 21
  36. Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A, 2014. 111(1): p. E34-43.
  37. Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S. Trapping of Cyclin G associated kinase (GAK) Kinase Conformations using Nanobodies Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399.
  38. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C.,* Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG Structure. Structure. 2014 Jan 7;22(1):116-24. doi: 10.1016/j.str.2013.09.021. Epub 2013 Nov 14.
  39. Isensee J, Diskar M, Waldherr S, Buschow R, Hasenauer J, Prinz A, Allgöwer F, Herberg FW, Hucho T Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons J Cell Sci. 2014 Jan 1;127(Pt 1):216-29. doi: 10.1242/jcs.136580
  40. Du X, Barisch C, Paschke P, Herrfurth C, Bertinetti O, Pawolleck N, Otto H, Rühling H, Feussner I, Herberg FW, Maniak M. Dictyostelium lipid droplets host novel proteins. Eukaryot Cell. 2013 Nov;12(11):1517-29.
  41. Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG. Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag Mol Endocrinol. 2013, 1267-82.
  42. Kämpf, K., Kübler, S., Herberg, F.w., Ehresmann, A. Magneto-optic surface plasmon resonance optimum layers: Simulations for biological relevant refractive index changes
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  43. Kummer L, Parizek P, Rube P, Millgramm B, Prinz A, Mittl PR, Kaufholz M, Zimmermann B, Herberg FW, Plückthun A. Phosphorylation-specific ERK kinase-binders from designed ankyrin repeat protein libraries Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2248-57. doi: 10.1073/pnas.1205399109. Epub 2012 Jul 27
  44. Parizek P, Kummer L, Rube P, Prinz A, Herberg FW, Plückthun A.Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases ACS Chem Biol. 2012 Aug 17;7(8):1356-66. doi: 10.1021/cb3001167
  45. Søberg K, Larsen AC, Diskar M, Backe PH, Bjørås M, Jahnsen T, Laerdahl JK, Rognes T, Herberg FW, Skålhegg BS. Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA) . PLoS One. 2012;7(4):e34838. Epub 2012 Apr 13.
  46. Düvel J, Bertinetti D, Möller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jänsch L, Herberg FW, Häussler S. A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. J Microbiol Methods. 2012 Feb;88(2):229-36
  47. Lolicato M, Nardini M, Gazzarrini S, Moeller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A. Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels. J Biol Chem. 2011 Dec 30;286(52):44811-20.
  48. Vetter MM, Zenn HM, Méndez E, van den Boom H, Herberg FW, Skålhegg BS.The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA. BMC Biochem. 2011 Aug 3;12:40.
  49. Schmidt J, Müsken M, Becker T, Magnowska Z, Bertinetti D, Möller S, Zimmermann B, Herberg FW, Jänsch L, Häussler S. The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling.PLoS One. 2011 Mar 22;6(3):e18184
  50. Christian F, Szaszak M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Goetz F, Zuehlke K, Moutty M, Goettert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gaspar R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E. Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.J Biol Chem. 2011 Mar 18;286(11):9079-96. Epub 2010 Dec 22.
  51. Hanke SE, Bertinetti D, Badel A, Schweinsberg S, Genieser HG, Herberg FW Cyclic nucleotides as affinity tools: phosphorothioate cAMP analogues address specific PKA subproteomes. N Biotechnol. 2011 Jul;28(4):294-301. Epub 2010 Dec 13.
  52. Diskar M, Zenn HM, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, Berrera M, Zaccolo M, Boshart M, Herberg FW, Prinz A Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit {alpha}H-{alpha}I loop.J Biol Chem. 2010 Nov 12;285(46):35910-8. Epub 2010 Sep 6.
  53. Erlbruch A, Hung CW, Seidler J, Borrmann K, Gesellchen F, König N, Kübler D, Herberg FW, Lehmann WD, Bossemeyer D. Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics. 2010 Aug;10(16):2890-900.
  54. Hundsrucker, C., P. Skroblin, F. Christian, M. Zenn, V. Popara, M. Joshi, J. Eichhorst, B. Wiesner, F. W. Herberg, B. Reif, W. Rosenthal and E. Klussmann (2010). "Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem. 2010 Feb 19;285(8):5507-21. Epub 2009 Dec 11.
  55. Gloriam, D. E., S. Orchard, D. Bertinetti, E. Bjorling, E. Bongcam-Rudloff, J. Bourbeillon, A. R. Bradbury, A. de Daruvar, S. Dubel, R. Frank, T. J. Gibson, N. Haslam, F. W. Herberg, T. Hiltke, J. D. Hoheisel, S. Kerrien, M. Koegl, Z. Konthur, B. Korn, U. Landegren, S. van der Maarel, L. Montecchi-Palazzi, S. Palcy, H. Rodriguez, S. Schweinsberg, V. Sievert, O. Stoevesandt, M. J. Taussig, M. Uhlen, C. Wingren, L. Gold, P. Woollard, D. J. Sherman and H. Hermjakob (2010). Report: A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics. 2010 Jan;9(1):1-10. Epub 2009 Aug 11.
  56. Schluter, S., C. M. Franz, F. Gesellchen, O. Bertinetti, F. W. Herberg and F. R. Schmidt (2009). The high biofilm-encoding Bee locus: a second pilus gene cluster in Enterococcus faecalis? Curr Microbiol 59(2): 206-11.
  57. Viertlboeck, B. C., S. Schweinsberg, R. Schmitt, F. W. Herberg and T. W. Gobel (2009). The chicken leukocyte receptor complex encodes a family of different affinity FcY receptors. J Immunol 182(11): 6985-92.
  58. Wojtal, K. A., M. Diskar, F. W. Herberg, D. Hoekstra and S. C. van Ijzendoorn (2009). Regulatory Subunit I-controlled Protein Kinase A Activity Is Required for Apical Bile Canalicular Lumen Development in Hepatocytes. J Biol Chem 284(31): 20773-80.
  59. Prinz A, Herberg FW: UCSD-Nature Molecule Page PrKX. 2009
  60. Bertinetti, D., Schweinsberg, S., Hanke, S. E., Schwede, F., Bertinetti, O., Drewianka, S., Genieser, H. G., and Herberg, F. W. (2009). Chemical tools selectively target components of the PKA system. BMC Chem Biol 9, 3.
  61. Zimmermann B, Schweinsberg S, Drewianka S, Herberg FW: Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J 2008, 413(1):93-101.
  62. Collins DM, Murdoch H, Dunlop AJ, Charych E, Baillie GS, Herberg FW, Brandon N, Prinz A, Houslay MD: Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal. 2008 Dec;20(12):2356-69
  63. Moll D, Prinz A, Brendel CM, Berrera M, Guske K, Zaccolo M, Genieser HG, Herberg FW: Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog. BMC Biochem 2008, 9(1):18.
  64. Farquhar MJ, Harris HJ, Diskar M, Jones S, Mee CJ, Nielsen SU, Brimacombe CL, Molina S, Toms GL, Maurel P, Howl J, Herberg FW, van Ijzendoorn SC, Balfe P and McKeating JA:: Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. J Virol 2008, 82(17):8797-8811
  65. Hamacher, M., Herberg, F., Ueffing, M., and Meyer, H. E. (2008). Seven successful years of Omics research: The Human Brain Proteome Project within the National German Research Network (NGFN). Proteomics 8, 1116-1117
  66. Schweinsberg, S., Moll, D., Burghardt, N. C., Hahnefeld, C., Schwede, F., Zimmermann, B., Drewianka, S., Werner, L., Kleinjung, F., Genieser, H. G., Schuchhardt, J., Herberg, F. W. . (2008). Systematic interpretation of cyclic nucleotide binding studies using KinetXBase. Proteomics 8, 1212-1220.
  67. Ruppelt, A., Mosenden, R., Gronholm, M., Aandahl, E. M., Tobin, D., Carlson, C. R., Abrahamsen, H., Herberg, F. W., Carpen, O., and Tasken, K. (2007). Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol 179, 5159-5168.
  68. Diskar M, Zenn, H.M., Kaupisch, A., Prinz, A., Herberg, F.W.: Molecular basis for isoform specific autoregulation of protein kinase A - insights from the human catalytic subunit PrKX (2007) Cell Signal. 2007 Oct;19(10):2024-34.
  69. Viertlböck, B. C., Schweinsberg, S., Hanczaruk, M. A., Schmitt, R., Herberg, F. W., and Göbel, T. W. (2007). The chicken leukocyte receptor complex encodes a primordial, activating, high affinity IgY Fc receptor. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11718-23.
  70. Mirow, N., Zimmermann, B., Maleszka, A., Knobel, H., Tenderich, G., Koerfer, R., and Herberg, F. W. (2007). Plasma protein properties to immobilized heparin and heparin-albumin-conjugate. Artif Organs 31(6):466–471
  71. Hamacher, M., Stephan, C., Eisenacher, M., van Hall, A., Marcus, K., Martens, L., Park, Y. M., Gutstein, H. B., Herberg, F., and Meyer, H. E. (2007). Proteomics for everyday use: Activities of the HUPO Brain Proteome Project during the 5(th) HUPO World Congress. Proteomics 7, 1012-1015
  72. Moll, D., Schweinsberg, S., Hammann, C., and Herberg, F. W. (2007). Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A. Biol Chem 388, 163-172.
  73. Taussig, M. J.; Stoevesandt, O.; Borrebaeck, C. A.; Bradbury, A. R.; Cahill, D.; Cambillau, C.; de Daruvar, A.; Dubel, S.; Eichler, J.; Frank, R.; Gibson, T. J.; Gloriam, D.; Gold, L.; Herberg, F. W.; Hermjakob, H.; Hoheisel, J. D.; Joos, T. O.; Kallioniemi, O.; Koegl, M.; Konthur, Z.; Korn, B.; Kremmer, E.; Krobitsch, S.; Landegren, U.; van der Maarel, S.; McCafferty, J.; Muyldermans, S.; Nygren, P. A.; Palcy, S.; Pluckthun, A.; Polic, B.; Przybylski, M.; Saviranta, P.; Sawyer, A.; Sherman, D. J.; Skerra, A.; Templin, M.; Ueffing, M.; Uhlen, M. (2007). ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nature Methods 4, 13-17.
  74. Viht, K., Schweinsberg, S., Lust, M., Vaasa, A., Raidaru, G., Lavogina, D., Uri, A., and Herberg, F. W. (2007). Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase. Anal Biochem 362, 268-277.
  75. Stokka, A.J., Gesellchen, F., Carlson, C.R., Scott, J.D., Herberg, F.W., Tasken, K. (2006) Characterization of A-kinase-anchoring disruptors using a solution based assay. Biochem J. 400 (3), 493-499.
  76. Terrin, A., Di Benedetto, G., Pertegato, V., Cheung, Y. F., Baillie, G., Lynch, M. J., Elvassore, N., Prinz, A., Herberg, F. W., Houslay, M. D., and Zaccolo, M. (2006). PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol 175, 441-451.
  77. Hamacher, M.; Apweiler, R.; Arnold, G.; Becker, A.; Bluggel, M.; Carrette, O.; Colvis, C.; Dunn, M. J.; Frohlich, T.; Fountoulakis, M.; van Hall, A.; Herberg, F.; Ji, J.; Kretzschmar, H.; Lewczuk, P.; Lubec, G.; Marcus, K.; Martens, L.; Palacios Bustamante, N.; Park, Y. M.; Pennington, S. R.; Robben, J.; Stuhler, K.; Reidegeld, K. A.; Riederer, P.; Rossier, J.; Sanchez, J. C.; Schrader, M.; Stephan, C.; Tagle, D.; Thiele, H.; Wang, J.; Wiltfang, J.; Yoo, J. S.; Zhang, C.; Klose, J.; Meyer, H. E. The HUPO Brain Proteome Project: Summary of the pilot phase and introduction of a comprehensive data reprocessing strategy Proteomics 6, 4890-4898.
  78. Gesellchen, F., Bertinetti, O., and Herberg, F. W. (2006a). Analysis of posttranslational modifications exemplified using protein kinase A. Biochim Biophys Acta 1764, 1788-1800.
  79. Moll, D., Gesellchen, F., Prinz, A., Drewianka, S., Zimmermann, B., and Herberg, F. W. (2006). Biomolecular interaction analysis in functional proteomics. J Neuronal Transmission 113, 1015-1032.
  80. Seitz, H., S. Hutschenreiter, C. Hultschig, C. Zeilinger, B. Zimmermann, F. Kleinjung, J. Schuchhardt, H. Eickhoff and F. W. Herberg (2006). Differential binding studies applying functional protein microarrays and surface plasmon resonance Proteomics 6, 5132-5139
  81. Gesellchen, F.; Prinz, A.; Zimmerman, B.; Herberg, F. (2006b) Quantification of cAMP antagonist action in vitro and in living cells. Eur J Cell Biol 85(7): 663-72.
  82. Prinz, A., M. Diskar, and F. Herberg, Application of Bioluminescence Resonance Energy Transfer (BRET) for biomolecular interaction studies. ChemBioChem, 2006 Chembiochem 7(7): 1007-1012
  83. Prinz, A.; Diskar, M.; Erlbruch, A.; Herberg, F.(2006) Novel, isotype-specific sensors for Protein Kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET). Cell Signal 18(10): 1616-25.
  84. Hundsrucker, C.; Krause, G.; Beyermann, M.; Prinz, A.; Zimmermann, B.; Diekmann, O.; Lorenz, D.; Stefan, E.; Nedvetsky, P.; Dathe, M.; Christian, F.; McSorley, T.; Krause, E.; McConnachie, G.; Herberg, F. W.; Scott, J. D.; Rosenthal, W.; Klussmann, E., (2006) High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A anchoring disruptor peptides. Biochem J.;396(2):297-306
  85. Ramanavicius, A.; Herberg, F. W.; Hutschenreiter, S.; Zimmermann, B.; Lapenaite, I.; Kaušaite, A.; Finkelšteinas, A.; Ramanavicien, A., Biomedical Application of Surface Plasmon Resonance Biosensors. Acta Medica Lithuania 2005, VOLUME 12, ( No. 3.), P. 1–9.
  86. Hahnefeld, C.; Moll, D.; Goette, M.; Herberg, F. W., Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA. Biol Chem 2005, 386, (7), 623-31.
  87. Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F. W., Valenti, G., Bachmann, S., Rosenthal, W. & Klussmann, E. (2004). Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem 279, 26654-65
  88. Thierse, H. J., Moulon, C., Allespach, Y., Zimmermann, B., Doetze, A., Kuppig, S., Wild, D., Herberg, F. & Weltzien, H. U. (2004). Metal-Protein Complex-Mediated Transport and Delivery of Ni(2+) to TCR/MHC Contact Sites in Nickel-Specific Human T Cell Activation. J Immunol 172, 1926-34.
  89. Gronholm, M., Vossebein, L., Carlson, C. R., Kuja-Panula, J., Teesalu, T., Alfthan, K., Vaheri, A., Rauvala, H., Herberg, F. W., Tasken, K. & Carpen, O. (2003). Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem 278, 41167-72
  90. Sichelschmidt, O. J., Hahnefeld, C., Hohlfeld, T., Herberg, F. W. & Schror, K. (2003). Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity. Cardiovasc Res 58(3), 602-610.
  91. Yaqub, S., Abrahamsen, H., Zimmerman, B., Kholod, N., Torgersen, K. M., Mustelin, T., Herberg, F. W., Tasken, K. & Vang, T. (2003). Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain. Biochem J 372(Pt 1), 271-8.
  92. Zimmermann, B., Hahnefeld, C. & Herberg, F. W. (2002). Applications of biomolecular interaction analysis in drug development. Targets Vol No. 2, 66-73.
  93. Carlson, C. R., Witczak, O., Vossebein, L., Labbe, J. C., Skalhegg, B. S., Keryer, G., Herberg, F. W., Collas, P. & Tasken, K. (2001). CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis. J Cell Sci 114(Pt 18), 3243-3254.
  94. Landsverk, H. B., Carlson, C. R., Steen, R. L., Vossebein, L., Herberg, F. W., Tasken, K. & Collas, P. (2001). Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis. J Cell Sci 114(Pt 18), 3255-64.
  95. Suer, S., Sickmann, A., Meyer, H. E., Herberg, F. W. & Heilmeyer, L. M. (2001). Human phosphatidylinositol 4-kinase isoform PI4K92 Expression of the recombinant enzyme and determination of multiple phosphorylation sites. Eur. J. Biochem. 268(7), 2099-106.
  96. Wang, X., Herberg, F. W., Laue, M. M., Wullner, C., Hu, B., Petrasch-Parwez, E. & Kilimann, M. W. (2000). Neurobeachin: A Protein Kinase A-Anchoring, beige/Chediak-Higashi Protein Homolog Implicated in Neuronal Membrane Traffic.    J Neurosci 20 (23), 8551-8565.
  97. Herberg, F. W., Maleszka, A., Eide, T., Vossebein, L. & Tasken, K. (2000). Analysis of A-Kinase Anchoring Protein (AKAP) Interaction with Protein Kinase A (PKA) Regulatory Subunits: PKA Isoform Specificity in AKAP Binding. J. Mol. Biol. 298 (2), 329-339.
  98. Herzog, A., Szegedi, C., Jona, I., Herberg, F.W., Varsanyi, M. (2000) Surface Plasmon Resonance studies prove the interaction of skeletal muscle sarcoplasmic reticular Ca2+ release channel/ryanodine receptor with calsequestrin. FEBS Letters 472, 73-77
  99. Toth, A., Kiss, E., Herberg, F. W., Gergely, P., Hartshorne, D. J. & Erdodi, F. (2000). Study of the subunit interactions in myosin phosphatase by surface plasmon resonance. Eur. J. Biochem. 267(6), 1687-1697.
  100. Herberg, F.W., Doyle, M., Cox, S. & Taylor, S.S. (1999) Dissection of the Nucleotide and Metal-Phosphate Binding Sites in cAMP-dependent Protein Kinase. Biochemistry 38 (19), 6352-60
  101. Zimmermann, B., Chiorini, J. Ma, Y., Kotin, R., and Herberg, F. (1999). PrKX is a Novel Catalytic Subunit of the cAMP-Dependent Protein Kinase regulated by the Regulatory Subunit Type I. J. Biol. Chem. 274:5370-5378
  102. Schliebs, W., Saidowski, J., Agianian, B., Dodt, G., Herberg, F. and Kunau, W. (1999) Recombinant Human PTS-1-Receptor PEX5: Structural Basis for Interaction of PEX5 with PEX14. J. Biol. Chem. 274:5666-5673
  103. Gehrmann, T., Gülkan, H., Suer S., Herberg F.W., Balla A., Vereb G., Mayr G.W., Heilmeyer L.M.G., Jr. (1999) Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230(1). Biochim Biophys Acta 1437:341-356
  104. Chiorini, J.A., Zimmermann, B., Yang, L., Smith, R.H., Ahearn, A., Herberg, F.W., Kotin, R.M. (1998) Inhibition of PrKX, a Novel Protein Kinase, and the cAMP-Dependent Protein Kinase PKA, by the Regulatory Proteins of Adeno-Associated Virus Type 2. Mol. Cell. Biol. 18, 5921-5929
  105. Reiffert, S. U., Jaquet, K., Heilmeyer jr., L. M. G. & Herberg, F. W. (1998) Stepwise Subunit Interaction Changes by Mono and Bisphosphorylation of Cardiac Troponin I. Biochemistry 37, 13516-13525.
  106. León, D., Herberg, F.W., Banky, P., and Taylor, S.S. (1997) A stable -Helical Domain at the N Terminus of the RIα Subunits of cAMP-dependent Protein Kinase Is a Novel Dimerization/Docking Motif. J. Biol. Chem. 272 (45), 28431-28437
  107. Herberg, F.W., Zimmermann, B., McGlone M.M. and Taylor, S.S. (1997) Importance of the A-helix of the catalytic subunit of the cAMP-dependent Protein kinase for stability and for orienting subdomains at the cleft interface.  Prot. Sci. 6 (3) 569-579
  108. Herberg, F.W., Taylor, S.S. and Dostmann, W.R.G.  (1996)  Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry   35 (9), 2934-42
  109. Wild, N., Herberg, F.W., Hofmann, F. and Dostmann, W.R.G. (1995) Expression of a chimeric cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I. FEBS  374 (3), 356-362
  110. Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, N-h, Taylor, S.S. and Varughese, K.I. (1995) Regulatory Subunit of  Protein Kinase A: Structure of a Deletion Mutant with cAMP Binding Domains Science 269: 807-813
  111. Herberg, F.W., Dostmann, W.R.G., Zorn, M., Davis, S.J. and Taylor, S.S. (1994) Crosstalk between Domains in the Regulatory Subunit of cAMP-dependent Protein Kinase: Influence of the Amino-Terminus of cAMP-binding and Holoenzyme Formation. Biochemistry 33:7485-7494
  112. Buechler, Y.J., Herberg, F.W. and Taylor, S.S. (1993) Regulation Defective Mutants of Type I cAMP-dependent Protein Kinase: Consequences of Replacing Arg94 and Arg95.  J. Biol. Chem.  268:16495-16503
  113. Herberg, F.W., Bell, S.M. and Taylor, S.S. (1993) Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase in E. coli: Multiple Isozymes Reflect Different Phosphorylation States. Prot. Eng.  6:771-777
  114. Herberg, F.W. and Taylor, S.S. (1993) Physiological Inhibitors of the Catalytic Subunit of cAMP-dependent Protein Kinase: Effect of MgATP on Protein/Protein Interaction.  Biochemistry  32:14015 -14022
  115. Benterbusch, R., Herberg, F.W., Melzer, W. Thieleczeck, R. (1992): Excitation-Contracting Coupling in a Pre-Vertebrate Twitch Muscle: The Myotomes of Branchiostoma lanceolatum. J. Membrane Biol. 129, 237-252.

 

Peer reviewed review articles

  1. Knape MJ and Herberg FW Metal coordination in kinases and pseudokinases Biochemical Society Transactions (2017) Jun 15;45(3):653-663. doi: 10.1042/BST20160327.
  2. Badel, A, Hanke, S and Herberg, FW: PKA: an Allrounder in Signal Transduction GIT 2010
  3. Roth S, Bertinetti O and Herberg F: Die Masse machts - Massenspektrometrie als interdisziplinäres Werkzeug. Bioforum 31: 30-32, 2008
  4. Diskar, M., F. W. Herberg and A. Prinz (2006). "Quantifizierung intrazellulärer Protein-Protein-Wechselwirkungen." Biospektrum 06: 629-631.
  5. Moll, D., et al., Biomolekulare Interaktionsanalyse - ein Werkzeug für die funktionelle Proteomforschung. Bioforum, 2006
  6. Moll, D., Zimmermann, B., Gesellchen, F. & Herberg, F. W. (2006c). Current developments for the in vitro characterization of protein interactions. In Proteomics in Drug Research (Marcus, K., Stühler, K., Warscheid, Hamacher, M., van Hall, A. & Meyer, H. E., eds.). Wiley-VCH, Weinheim. pp. 159-172.
  7. Gesellchen F, Zimmermann B and Herberg FW: (2005) Direct optical detection of protein-ligand interactions. Methods Mol Biol 305: 17-46,
  8. Hahnefeld, C., Drewianka, S. & Herberg, F. W. (2004). Determination of Kinetic Data Using Surface Plasmon Resonance Biosensors. Methods Mol Med, 299-320.
  9. Marcus, K., Hultschig, C., Frank, R., Herberg, F., Schuchhardt, J. & Seitz, H. (2003). Innovative Forschungsansätze im NGFN Verbund"The Human Brain Proteome Project HBPP". Genome Express 4.03; 5-8
  10. Herberg, F.W., and B. Zimmermann (1999). Analysis of protein kinase interactions using biomolecular interaction analysis. In PROTEIN PHOSPHORYLATION - A PRACTICAL APPROACH, D. G. Hardie, ed. (Oxford: Oxford University Press) 2nd ed. pp 335-71.
  11. Taylor, S., Radzio-Andzelm, E., Knighton, D., Eyck, L.T., Sowadski, J., Herberg, F., Yonemoto, W. and Zheng, J. (1993) Crystal Structures of the Catalytic Subunit of cAMP-Dependent Protein Kinase Reveal General Features of the Protein Kinase Family.  Receptor  3:165-172 (2,0)
  12. Taylor, S., Zheng, J., Radzio-Andzelm, E., Knighton, D., Eyck, L.T., Sowadski, J., Herberg, F. and Yonemoto, W. (1993) cAMP-Dependent Protein Kinase Defines a Family of Enzymes.  Phil. Trans. R. Soc. Lond. B. 340:315-324 (2,8)

 

Peer reviewed book chapters

  1. Lorenz R, Bertinetti D, Herberg FW. cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors. Handb Exp Pharmacol. 2017;238:105-122. doi: 10.1007/164_2015_36.
  2. Lorenz R, Hahnefeld C, Möller S, Bertinetti D and Herberg FW “Cyclic nucleotide analogs as chemical tools for interaction analysis” In: X. Cheng, editor, Cyclic Nucleotide Signaling, pages 203-23. CRC Press (2015)
  3. Eichler C, Herberg F, Schmidt F, Schaffrath R. (2013).  Does the bee locus encode an additional or alternative pilus in Enterococcus faecalis? In: Worldwide Research Efforts in the Fighting against Microbial Pathogens: From Basic Research to Technological Developments, Mendez-Vilas A (ed), BrownWalker Press (Boca Raton, FL, USA), pp. 134-138
  4. Zenn HM, Hutschenreiter S and Herberg FW Anti-Histidine Antibodies as Tools for Reversible  Capturing of His-Tagged Fusion Proteins for Subsequent Binding Analysis  in R. Kontermann and S. Dübel (eds.), Antibody Engineering, Chapter , 42DOI 10.1007/978-3-642-01144-3_42, # Springer-Verlag Berlin Heidelberg 2010 page 667-681
  5. Zeilinger, C. & Herberg, F. (2004). Chip Design für die Biomolekulare Interaktionsanalyse. Telekommunikation aktuell 58, 65-70
  6. Vossebein, L and Herberg, FW (2001). NATO/FEBS Advanced Study Institute on Protein Modules in Cellular Signaling, Le Hameau de l'Ètoile, St. Martin de Londres, France Multiplicity and Anchoring of PKA Isozymes Detected by Surface Plasmon Resonance NATO ASI Series A 313, 50 – 59
  7. Zimmermann, B., Klink, A., Rappolt, G., Herberg, F.W. (1997) Protein Kinase X: A Novel Human Protein Kinase related to the Catalytic Subunit of cAMP-dependent Protein Kinase. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 15-18
  8. Maleszka, A. and Herberg, F.W. (1997): Interaction Studies using Biosensors. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 27-36
  9. Reiffert, S., Jaquet, K, Heilmeyer, L.M.G., Herberg, F.W. (1997) Studies on the Function of Different Phosphoforms of Cardiac Troponin I. in: Interacting Protein Domains, NATO ASI Series H, Vol 102, 281-288
  10. Herberg, F.W., Yonemoto, W. and S.S. Taylor (1993): The Catalytic Subunit of cAMP-dependent Protein Kinase. in: Tyrosine Phosphorylation/ Dephosphorylation and Downstream Signalling NATO ASI Series: 203-213
  11. Herberg F.W., and S.S. Taylor (1991): Conformational and Shape Changes associated with cAMP-dependent Protein Kinase. Cellular Regulation by Protein Phosphorylation NATO ASI Series, Vol. H 59: 119-123.
  12. Taylor, S.S., Yonomoto, W., Dostmann, W., Knighton, D., Sowadski, J., Herberg, F., Buechler, J. and Y. Ji-Buechler (1991): Protein kinase Structure and Function: cAMP-dependent Protein Kinase. Cellular Regulation by Protein Phosphorylation NATO ASI Series, Vol. H 59:91-105.
  13. Herberg, F.W., Thieleczek, R and L.M.G. Heilmeyer Jr. (1988): Preparation and Characterization of Myotome Membrane Vesicles of Branchiostoma lanceolatum in: Sarcomeric and Non-Sarcomeric Muscles: Basic and Applied Research Prospects for the 90's, ed.: U. Carraro: 619-24.

 

Industry

  1. Langer A, Knape M and Herberg FW Hydrodynamic diameter and thermal stability measurements of protein inase A using switchSENSE Application note 2017
  2. Lenz, C.; Bertinetti, O.; Herberg, F. W., Complete Characterization of the Phosphorylation Sites of a Protein Kinase. Technical Note Applied Bosystems 2005
  3. Zimmermann, B., Herberg, F.W. (1998) Interactions of 6xHis-tagged protein kinase A catalytic subunit examined using Ni-NTA Magnetic agarose beads, QIAGEN NEWS (4) 1998, 9-10
  4. De Stefano, M., Herberg, F.W., Frey, R. (1998) Schnelle Trennung von Isoenzymen LaborPraxis 3 (22) 88 - 92
  5. Jaeger, W., Haase, B., Lutz, V., Herberg, F.W., Zimmermann, B. (1997) Biomolekulare Interaktionsanalyse (BIA) mit SPR-Biosensortechnologie Biospektrum 3 (4) 82-87