Proteins involved in lipid metabolism (FcsA)

• Overview (pg.1) (pg.2)
• FcsA
• Plin (pg.1)(pg.2)
• Smt1, Ldp, Net4
• Dgat1
• Dgat2
• FcsB (pg.1)(pg.2)

Top: Fatty acids (FA) taken up into endosomes are activated by linkage to coenzyme a (CoA). This occurs through the action of the FcsA protein (green dots) bound to the endosomal membrane. Only FA-CoA molecules can be converted into TAG, filling lipid droplets.

Right: Alternating images of wildtype Dictyostelium cells and a fcsA mutant in the presence of fluorescently labelled fatty acids.

Function: The fcsA-mutant is deficient in the formation of lipid droplets.

Reference:

• von Löhneysen, K., Pawolleck, N., Rühling, H., and Maniak, M.: A Dictyostelium Long Chain Fatty Acyl Coenzyme A Synthetase mediates fatty acid retrieval from endosomes. Eur.J. Cell Biol., 82, 505 - 514, 2003