Proteins involved in endocytic transit (Actin)

Actin Text

Top: Actin (yellow dots) on nascent (light-gray) and mature (dark-gray) endosomes.

Right: Coincidence of actin (red) with an endosomal marker protein (green).

Actin Text 2

Function: When actin is removed from mature endosomes by the means of site-directed depolymerisation, brought about by expressing a vacuolin-myc-cofilin fusion, endosomes aggregate into large clusters. See the alterning image on the right side.


Drengk et al., 2003

  • Drengk, A., Fritsch, J., Schmauch, C., Rühling, H., and Maniak, M.: A coat of filamentous actin prevents clustering of late endosomal vacuoles in vivo. Curr. Biol. 13, 1814 - 1819, 2003

Rauchenberger et al., 1997

  • Rauchenberger, R., Hacker, U., Murphy, J., Niewöhner, J. & Maniak, M.: Coronin and vacuolin identify consecutive stages of a late, actin-coated endocytic compartment in Dictyostelium. Current Biology 7, 215-218, 1997